Methyl 1H-indazole-6-carboxylate
- Product Name
- Methyl 1H-indazole-6-carboxylate
- CAS No.
- 170487-40-8
- Chemical Name
- Methyl 1H-indazole-6-carboxylate
- Synonyms
- 1H-indazole-6-carboxylate;Methyl indazole-6-carboxy...;Methyl indazole-6-carboxylate;Methyl 1H-indazol-6-carboxylate;METHYL 1H-INDAZOLE-6-CARBOXYLATE;1H-Indazole-6-carboxylic acid methyl;INDAZOLE-6-CARBOXYLIC ACID METHYL ESTER;1H-Indazole-6-carboxylic acid methyl ester;6-(1H)INDAZOLE CARBOXYLIC ACID METHYL ESTER;1H-Indazole-6-carboxylic acid methyl ester
- CBNumber
- CB6127192
- Molecular Formula
- C9H8N2O2
- Formula Weight
- 176.17
- MOL File
- 170487-40-8.mol
Methyl 1H-indazole-6-carboxylate Property
- Melting point:
- 142-144℃
- Boiling point:
- 345.2±15.0 °C(Predicted)
- Density
- 1.324±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- pka
- 12.43±0.40(Predicted)
- color
- White to Light yellow to Light orange
- Water Solubility
- Soluble in water.
- InChI
- InChI=1S/C9H8N2O2/c1-13-9(12)6-2-3-7-5-10-11-8(7)4-6/h2-5H,1H3,(H,10,11)
- InChIKey
- TUSICEWIXLMXEY-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC(C(OC)=O)=C2)C=N1
Safety
- WGK Germany
- 3
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- SYX00165
- Product name
- 1H-Indazole-6-carboxylic acid methyl ester
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $201
- Updated
- 2023/01/07
- Product number
- M2823
- Product name
- Methyl Indazole-6-carboxylate
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $29
- Updated
- 2025/07/31
- Product number
- M2823
- Product name
- Methyl Indazole-6-carboxylate
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $84
- Updated
- 2025/07/31
- Product number
- M321405
- Product name
- Methyl1H-Indazole-6-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 069837
- Product name
- 1H-Indazole-6-carboxylic acid methyl ester
- Purity
- 97%
- Packaging
- 1g
- Price
- $72
- Updated
- 2021/12/16
Methyl 1H-indazole-6-carboxylate Chemical Properties,Usage,Production
Uses
Methyl 1H-indazole-6-carboxylate?is used in organic synthesis.
Synthesis
18595-18-1
170487-40-8
Example 1 Preparation of 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(dimethylcarbamoyl)-1H-indazol-3-yl)cyclohex-3-enecarboxylic acid (1A) Step 1: Preparation of methyl 1H-indazole-6-carboxylate (A-2). Methyl 3-amino-4-methylbenzoate (A-1) (5.0 g, 30.2 mmol) was dissolved in acetic acid (140 mL). An aqueous solution of sodium nitrite (2.1 g, 30.2 mmol) was added slowly and dropwise (3.5 mL) to the reaction mixture under cooling in an ice bath. After removing the ice bath, the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, about half of the solvent was removed by evaporation, and the remaining mixture was diluted with water (80 mL) and extracted with ethyl acetate (3 x 30 mL). The organic phases were combined, washed sequentially with water and saturated saline (2×200 mL each), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the product A-2 (4.4 g, 83% yield). LCMS (ESI): calculated value for C9H8N2O2, [M + H]+: 177, measured value: 177.
References
[1] Patent: WO2008/61109, 2008, A2. Location in patent: Page/Page column 29-30
[2] Patent: WO2014/26328, 2014, A1. Location in patent: Page/Page column 39-40
[3] Patent: WO2014/28597, 2014, A2. Location in patent: Page/Page column 56
[4] Patent: WO2014/26327, 2014, A1. Location in patent: Page/Page column 59
[5] Patent: WO2014/28600, 2014, A2. Location in patent: Page/Page column 50; 51
Methyl 1H-indazole-6-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 1H-indazole-6-carboxylate Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
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- Country
- Europe
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View Lastest Price from Methyl 1H-indazole-6-carboxylate manufacturers
- Product
- Methyl 1H-indazole-6-carboxylate 170487-40-8
- Price
- US $120.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 1000000
- Release date
- 2024-08-15
- Product
- Methyl 1H-indazole-6-carboxylate 170487-40-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-13
- Product
- Methyl 1H-indazole-6-carboxylate 170487-40-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-14