ChemicalBook > CAS DataBase List > 2-Bromo-3-cyanopyridine

2-Bromo-3-cyanopyridine

Product Name: 2-Bromo-3-cyanopyridine
CAS No.: 20577-26-8
Chemical Name: 2-Bromo-3-cyanopyridine
Synonyms: 2-Bromo-3-cyanopyridine;2-BROMOPYRIDINE-3-CARBONITRILE;IFLAB-BB F1957-0002;2-BroMo-nicotionitrile;2-broMo-3-cyanopyridin;2-BROMO-NICOTINONITRILE;2-Bromonicotinonitrile 98%;2-Bromo-3-cyanopyridine,98%;2-Bromo-3-pyridinecarbonitrile;3-Pyridinecarbonitrile,2-broMo-
CBNumber: CB6137362
Molecular Formula: C6H3BrN2
Formula Weight: 183.01
MOL File: 20577-26-8.mol

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2-Bromo-3-cyanopyridine Property

Melting point:: 105 °C
Boiling point:: 296.9±25.0 °C(Predicted)
Density: 1.72±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: Solid
pka: -2.66±0.10(Predicted)
Appearance: White to light yellow Solid

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Safety

HazardClass: 6.1
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B682828
Product name: 2-Bromo-3-cyanopyridine
Packaging: 1g
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H37-9-Z8
Product name: 2-Bromonicotinonitrile
Packaging: 1g
Price: $90
Updated: 2021/12/16

Matrix Scientific

Product number: 072104
Product name: 2-Bromo-3-cyanopyridine
Purity: 95+%
Packaging: 5g
Price: $99
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB12363
Product name: 2-Bromo-3-cyanopyridine
Packaging: 2g
Price: $630
Updated: 2021/12/16

Matrix Scientific

Product number: 072104
Product name: 2-Bromo-3-cyanopyridine
Purity: 95+%
Packaging: 25g
Price: $358
Updated: 2021/12/16

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2-Bromo-3-cyanopyridine Chemical Properties,Usage,Production

Synthesis

20577-27-9

20577-26-8

General procedure for the synthesis of 2-bromo-3-cyanopyridine from 2-oxo-1,2-dihydropyridine-3-carbonitrile: First, 2-chloro-3-cyanopyridine (3.68 mg, 26 mmol) was refluxed in acetic acid (100 mL) for 12 hours. After completion of the reaction, the evaporated residue was dissolved in a solvent mixture of tetrahydrofuran (80 mL) and water (20 mL) and refluxed for 4 hours. Evaporation of the solvent gave 3-cyanopyridin-2-one (3.12 g, quantitative yield) as white crystals with a melting point of 110-114 °C (literature value 13174-175 °C). Its nuclear magnetic resonance hydrogen spectrum (1H NMR) showed δ 6.47 (1H, t, J = 6.6 Hz, 5-H), 7.91 (1H, dd, J = 6.5, 2.1 Hz, 4-H), 8.14 (1H, dd, J = 7.0, 2.1 Hz, 6-H), and 11.48 (1H, s, 1-H); and nuclear magnetic resonance carbon spectrum (13C NMR) showed δ 105.80 (3-C), 124.05 (5-C), 141.87 (CN), 144.50 (6-H), 150.02 (4-C), 154.20 (2-C); mass spectrum (MS) m/z 143.0214 (M + Na)+ (calculated value C6H4N2NaO 143.0222). Next, tetrabutylammonium bromide (Bu4NBr, 8.55 g, 26 mmol) and phosphorus pentoxide (P2O5, 3.67 g, 26 mmol) were heated in toluene (250 mL) at 80 °C for 30 min. Then 3-cyanopyridin-2-one (1.59 g, 13 mmol) prepared above was added and the mixture was refluxed for 12 hours. After completion of the reaction, the mixture was cooled, poured into cold water and extracted twice with ethyl acetate. The organic layers were combined, dried and the solvent was evaporated to give 2-bromo-3-cyanopyridine (2.24 g, 94% yield) as white crystals with a melting point of 114-118 °C (literature values 14 °C, 105 °C). Infrared spectra (IR) showed νmax 2236, 1574, 1550, 1472 cm-1 ; nuclear magnetic resonance hydrogen spectra (1H NMR, CDCl3) showed δ 7.42 (1H, dd, J = 7.7, 4.8 Hz, 5-H), 8.01 (1H, dd, J = 7.8, 2.0 Hz, 4-H), 8.57 (1H, dd, J = 4.9, 2.0 Hz, 6-H); nuclear magnetic resonance carbon spectrum (13C NMR) showed δ 114.27 (3-C), 115.63 (CN), 122.37 (5-C), 142.53 (4-C), 143.84 (2-C), 152.92 (6-C).

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 13, p. 3013 - 3032

2-Bromo-3-cyanopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Bromo-3-cyanopyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-BROMO-NICOTINONITRILE 20577-26-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

Career Henan Chemical Co

Product: 2-BROMO-NICOTINONITRILE 20577-26-8
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-04

20577-26-8, 2-Bromo-3-cyanopyridineRelated Search:

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IFLAB-BB F1957-0002

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2-BroMo-nicotionitrile

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2-Bromopyridine-3-carbonitrile, 2-Bromo-3-cyanopyridine

2-Bromonicotinonitrile 98%

2-Bromo-3-cyanopyridine,98%

2-BROMO-NICOTINONITRILE ISO 9001：2015 REACH

2-Bromo-3-cyanopyridine

20577-26-8

Heterocycle-Pyridine series

cyanide| alkyl bromide

pyridine