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L-KYNURENINE

Product Name
L-KYNURENINE
CAS No.
2922-83-0
Chemical Name
L-KYNURENINE
Synonyms
CCRIS 4425;L-KYNURENINE;JACS-2922-83-0;(S)-Kynurenine;Kynurenine (L);L-Kynurenine L-Kynurenine Hydrate;L-kynurenine free base;L-KynurenineHydrate>L-KYNURENINE USP/EP/BP
CBNumber
CB6142966
Molecular Formula
C10H12N2O3
Formula Weight
208.21
MOL File
2922-83-0.mol
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L-KYNURENINE Property

Melting point:
219 °C
Boiling point:
466.6±45.0 °C(Predicted)
Density 
1.343±0.06 g/cm3(Predicted)
refractive index 
-33 ° (C=0.4, H2O)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Soluble in DMSO (up to 2 mg/ml) or in Water (up to 2 mg/ml).
pka
2.21±0.23(Predicted)
form 
crystalline
color 
light yellow
optical activity
-30.525 (H2O)
Merck 
14,5328
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
InChIKey
YGPSJZOEDVAXAB-QMMMGPOBSA-N
CAS DataBase Reference
2922-83-0(CAS DataBase Reference)
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Safety

WGK Germany 
3
RTECS 
CY9049700
HS Code 
2922500090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
K8625
Product name
L-Kynurenine
Purity
≥98% (HPLC)
Packaging
25mg
Price
$72.7
Updated
2024/03/01
Sigma-Aldrich
Product number
K8625
Product name
L-Kynurenine
Purity
≥98% (HPLC)
Packaging
1g
Price
$518
Updated
2024/03/01
TCI Chemical
Product number
K0016
Product name
L-Kynurenine Hydrate
Purity
>98.0%(T)
Packaging
100mg
Price
$127
Updated
2024/03/01
Alfa Aesar
Product number
J60199
Product name
L-Kynurenine
Packaging
50mg
Price
$79.7
Updated
2024/03/01
Cayman Chemical
Product number
11305
Product name
Kynurenine
Purity
≥98%
Packaging
50mg
Price
$37
Updated
2024/03/01
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L-KYNURENINE Chemical Properties,Usage,Production

Description

Kynurenine (2922-83-0) is a tryptophan catabolite.1?Endogenous tumor-promoting ligand of the human aryl hydrocarbon receptor (AhR). Constitutively generated by human tumor cells via the action of the tryptophan degrading enzyme, tryptophan-2,3-dioxygenase (TDO). Kynurenine suppresses antitumor immune responses and promotes tumor cell survival and motility.2

Uses

L-Kynurenine has been used as a standard for indoleamine-2,3-dioxygenase (IDO) assay. It has also been used as a standard to extract and quantify kynurenine from cultured cells and media.

Definition

ChEBI: A kynurenine that has L configuration.

Biochem/physiol Actions

Key intermediate in the breakdown pathway of tryptophan.

storage

Store at RT

References

References/Citations 1) Ibana?et al. (2011),?Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlaydia trachomatis persistence in human epithelial cells; Infect. Immun.,?79?4425 2) Opitz?et al. (2011),?An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor; Nature,?478?197

L-KYNURENINE Preparation Products And Raw materials

Raw materials

Preparation Products

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L-KYNURENINE Suppliers

Americas 1 China 172 Europe 1 France 2 Germany 4 India 5 Japan 1 Switzerland 4 United Kingdom 6 United States 28 Global 224
Carl Roth offre
Tel
--
Fax
--
Email
r.eckert@rothsochiel.fr
Country
France
ProdList
2361
Advantage
58
Alsachim SAS
Tel
--
Fax
--
Email
sales@alsachim.com
Country
France
ProdList
424
Advantage
0
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View Lastest Price from L-KYNURENINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
L-kynurenine 2922-83-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26
Career Henan Chemical Co
Product
L-KYNURENINE 2922-83-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-12-30
Career Henan Chemical Co
Product
L-KYNURENINE 2922-83-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-12-30

2922-83-0, L-KYNURENINERelated Search:

3-HYDROXY-L-KYNURENINE 2-(3-INDOLYLMETHYL)-L-TRYPTOPHAN 2-Hydroxy-DL-tryptophan 2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-3-CARBOXYLIC ACID HARMANE-1,2,3,4-TETRAHYDRO-3-CARBOXYLIC ACID Tryptophan EP Impurity L Tryptophan EP Impurity F PEAK E Tryptophan EP Impurity D Tryptophan EP Impurity J N'-formyl-L-Kynurenine Dioxindolyl-L-alanine 5-Hydroxytryptophan 3-(phenylamino)alanine D-1,2,3,4-tetrahydronorharmane-3-carboxylic acid N-formylkynurenine H-PHE-TRP-OH L-Isovaline

  • Tryptophan Impurity 3（Tryptophan EP Impurity C）
  • JACS-2922-83-0
  • L-2-AMINO-3-(2-AMINOBENZOYL)PROPIONIC ACID
  • L-2-AMINO-4-[2-AMINOPHENYL]-4-OXOBUTANOIC ACID
  • L-KYNURENINE
  • L-kynurenine free base
  • β-Anthraniloyl-L-alanine
  • β-Anthraniloyl-L-alanine, L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid
  • L-Kynurenine Hydrate
  • (S)-2-Amino-4-oxo-4-(2-aminophenyl)butanoic acid
  • (S)-α,2-Diamino-γ-oxobenzenebutanoic acid
  • 3-(2-Aminobenzoyl)alanine
  • 3-(2-Aminobenzoyl)-L-alanine
  • (2S)-2-amino-4-(2-aminophenyl)-4-keto-butyric acid
  • (2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid
  • (2S)-2-azanyl-4-(2-azanylphenyl)-4-oxo-butanoic acid
  • Benzenebutanoic acid, a,2-diaMino-g-oxo-, (aS)-
  • (S)-2-AMino-4-(2-aMinophenyl)-4-oxobutanoic acid
  • L-3-(o-Aminobenzoyl)alanine
  • L-Kynurenine&nbsp
  • <small>L</small>-Kynurenine Hydrate
  • L-KYNURENINE, >=98% (HPLC)
  • Tryptophan EP Impurity C
  • L-KynurenineHydrate&gt
  • (S)-Kynurenine
  • Benzenebutanoic acid, α,2-diamino-γ-oxo-, (αS)-
  • L-KYNURENINE USP/EP/BP
  • N-Acetyltryptophan EP Impurity C
  • Benzenebutanoic acid, α,2-diamino-γ-oxo-, (αS)-
  • Kynurenine (L)
  • c.?(S)-2-amino-4-(2-aminophenyl)-4-oxobutanoicacid(kynurenine),
  • L-Kynurenine (Tryptophan Impurity)
  • CCRIS 4425
  • β-Anthraniloyl-L-alanine
  • Tryptophan - Impurity C
  • 2922-83-0
  • C10H12N2O313H2O
  • C10H12N2O3xH2O
  • Amino Acid
  • BioChemical
  • Metabolomics
  • Metabolites and Cofactors on the Metabolic Pathways Chart
  • Metabolic Pathways
  • Amino Acids
  • Amino Acids
  • Biochemistry
  • non-Proteinorganic Amino Acids