L-Isovaline

Product Name: L-Isovaline
CAS No.: 595-40-4
Chemical Name: L-Isovaline
Synonyms: (S)-2-Amino-2-Methylbutanoic Acid;NSC1019;NSC 1019;NSC-1019;L-Isovaline;Isovaline L-;L-isovaline, >97%;a-Me-Gly(Ethyl)-OH;2,3-Dimethylalanine;H-alpha-Et-D-Ala-OH
CBNumber: CB2430610
Molecular Formula: C5H11NO2
Formula Weight: 117.15
MOL File: 595-40-4.mol

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L-Isovaline Property

Melting point:: 289.39°C (estimate)
Boiling point:: 213.6±23.0 °C(Predicted)
alpha: D25 +11.13° (c = 5 in H2O)
Density: 1.2000 (estimate)
refractive index: 1.4650 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 2.38±0.10(Predicted)
form: Fine Crystalline Powder
color: White
optical activity: Consistent with structure
InChI: InChI=1S/C5H11NO2/c1-3-5(2,6)4(7)8/h3,6H2,1-2H3,(H,7,8)/t5-/m1/s1
InChIKey: GCHPUFAZSONQIV-RXMQYKEDSA-N
SMILES: C(O)(=O)[C@](CC)(C)N
CAS DataBase Reference: 595-40-4(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
TSCA: No

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Chem-Impex

Product number: 33574
Product name: ()-2-Amino-2-methylbutyric acid
Packaging: 100MG
Price: $40
Updated: 2021/12/16

ChemSupplyAustralia

Product number: 300578
Product name: (S)-α-Ethylalanine·H2O, 98%
Packaging: 100mg
Price: $41.8
Updated: 2021/12/16

ChemScene

Product number: CS-W020180
Product name: L-Isovaline
Packaging: 100mg
Price: $54
Updated: 2021/12/16

Chem-Impex

Product number: 33574
Product name: ()-2-Amino-2-methylbutyric acid
Packaging: 250MG
Price: $70
Updated: 2021/12/16

ChemScene

Product number: CS-W020180
Product name: L-Isovaline
Packaging: 250mg
Price: $91
Updated: 2021/12/16

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L-Isovaline Chemical Properties,Usage,Production

Uses

a-Me-Gly(Ethyl)-OH is used in preparation of peptide compound comprising highly sterically hindered amino acid via reaction of electron-withdrawing group-protected N-unsubstituted-α,α-disubstituted amino acid with peptide followed by N-alkylation.

Synthesis

13893-46-4

595-40-4

1.4) Compound F1 (13.8 g, 95.0 mmol) and sodium hydroxide (7.6 g, 190.08 mmol) were added sequentially to a mixture of ethanol (200 mL) and water (1:1 by volume) and heated to reflux for 4 hours. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 7 with 2 M hydrochloric acid solution, followed by evaporation of the solvent. The residue was dissolved in a small amount of water and purified by strongly acidic cation exchange resin 732. The final product G1 (10 g, 90% yield) was obtained as a white solid.

Purification Methods

Crystallise it from aqueous Me2CO, or better by dissolving in H2O and adding excess Me2CO. [Baker et al. J Am Chem Soc 74 4701 1952, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2573-2577 1961.]

References

[1] Patent: CN108440320, 2018, A. Location in patent: Paragraph 0033; 0035; 0043

L-Isovaline Preparation Products And Raw materials

Raw materials

Preparation Products

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L-Isovaline Suppliers

China 97 Germany 3 India 2 Japan 1 United Kingdom 3 United States 15 Global 121

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Thermo Fisher Scientific

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Beijing innoChem Science & Technology Co.,Ltd.

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View Lastest Price from L-Isovaline manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: L-Isovaline 595-40-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-12

Career Henan Chemical Co

Product: L-Isovaline 595-40-4
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-22

595-40-4, L-IsovalineRelated Search:

ALTRENOGEST 4-Aminobutyric acid MCPB 2,2-Bis(hydroxymethyl)butyric acid Valine Glycine 2-Methyl butyric acid 6-Aminocaproic acid N,N-Dimethyl-1,4-phenylenediamine H-PHE-TRP-OH L-KYNURENINE (S)-2-Amino-2-methyl-butyric acid hydrochloride Tris(hydroxymethyl)aminomethane (R)-2-Amino-2-methyl-4-pentenoic acid 1-TERT-BUTOXYCARBONYLAMINO-CYCLOHEXANECARBOXYLIC ACID Dimethyl methyldopa S-(-)-Carbidopa ALPHA-METHYL-L-P-TYROSINE

L(+)-Isovaline Monohydrate

2,3-Dimethylalanine

2-azanyl-2-methyl-butanoic acid

L(+)-Isovaline Monohydrate, (>99% ee), 99+% 250MG

(S)-Α-ETHYLALANINE·H<SUB>2<SUB>O

α-Me-Gly(Ethyl)-OH·H<sub>2<sub>O

(S)-2-Amino-2-Methylbutanoic Acid

(S)-(+)-2-Amino-2-methylbutanoicacidmonohydrate(e.e.)

(S)-(+)-2-AMINO-2-METHYLBUTANOIC ACID 1-HYDRATE (E.E.)

(S)-(+)-2-Amino-2-methylbutanoic acid monohydrate

(R)-2-AMINO-2-METHYLBUTYRIC ACID

L-Isovaline

L-ISO-VALINE((S)-2-AMINO-2-METHYLBUTANOIC ACID)

(S)-alpha-Ethylalanine (>98%, >99%ee)

H-alpha-Et-D-Ala-OH

α-Me-Gly(Ethyl)-OH·H2O

(2S)-2-amino-2-methylbutanoic acid

2-(4-ethoxyanilino)-6-(hydroxymethyl)oxane-3,4,5-triol

L-isovaline, >97%

L-Isovaline USP/EP/BP

a-Me-Gly(Ethyl)-OH

NSC 1019

NSC1019

NSC-1019

Isovaline L-

(S)-α-Ethylalanine?H2O

(S)-a-Ethylalanine·H2O

595-40-4

1400942-35-3

Amino Acid Derivatives

Valine [Val, V]

unnatural amino acids

pharmacetical

α-Methyl Amino Acids