ChemicalBook > CAS DataBase List > L-Isovaline

L-Isovaline

Product Name
L-Isovaline
CAS No.
595-40-4
Chemical Name
L-Isovaline
Synonyms
(S)-2-Amino-2-Methylbutanoic Acid;NSC1019;NSC 1019;NSC-1019;L-Isovaline;Isovaline L-;L-isovaline, >97%;a-Me-Gly(Ethyl)-OH;2,3-Dimethylalanine;H-alpha-Et-D-Ala-OH
CBNumber
CB2430610
Molecular Formula
C5H11NO2
Formula Weight
117.15
MOL File
595-40-4.mol
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L-Isovaline Property

Melting point:
289.39°C (estimate)
Boiling point:
213.6±23.0 °C(Predicted)
alpha 
D25 +11.13° (c = 5 in H2O)
Density 
1.2000 (estimate)
refractive index 
1.4650 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
2.38±0.10(Predicted)
form 
Fine Crystalline Powder
color 
White
optical activity
Consistent with structure
InChI
InChI=1S/C5H11NO2/c1-3-5(2,6)4(7)8/h3,6H2,1-2H3,(H,7,8)/t5-/m1/s1
InChIKey
GCHPUFAZSONQIV-RXMQYKEDSA-N
SMILES
C(O)(=O)[C@](CC)(C)N
CAS DataBase Reference
595-40-4(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
TSCA 
No
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Chem-Impex
Product number
33574
Product name
()-2-Amino-2-methylbutyric acid
Packaging
100MG
Price
$40
Updated
2021/12/16
ChemSupplyAustralia
Product number
300578
Product name
(S)-α-Ethylalanine·H2O, 98%
Packaging
100mg
Price
$41.8
Updated
2021/12/16
ChemScene
Product number
CS-W020180
Product name
L-Isovaline
Packaging
100mg
Price
$54
Updated
2021/12/16
Chem-Impex
Product number
33574
Product name
()-2-Amino-2-methylbutyric acid
Packaging
250MG
Price
$70
Updated
2021/12/16
ChemScene
Product number
CS-W020180
Product name
L-Isovaline
Packaging
250mg
Price
$91
Updated
2021/12/16
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L-Isovaline Chemical Properties,Usage,Production

Uses

a-Me-Gly(Ethyl)-OH is used in preparation of peptide compound comprising highly sterically hindered amino acid via reaction of electron-withdrawing group-protected N-unsubstituted-α,α-disubstituted amino acid with peptide followed by N-alkylation.

Synthesis

13893-46-4

595-40-4

1.4) Compound F1 (13.8 g, 95.0 mmol) and sodium hydroxide (7.6 g, 190.08 mmol) were added sequentially to a mixture of ethanol (200 mL) and water (1:1 by volume) and heated to reflux for 4 hours. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 7 with 2 M hydrochloric acid solution, followed by evaporation of the solvent. The residue was dissolved in a small amount of water and purified by strongly acidic cation exchange resin 732. The final product G1 (10 g, 90% yield) was obtained as a white solid.

Purification Methods

Crystallise it from aqueous Me2CO, or better by dissolving in H2O and adding excess Me2CO. [Baker et al. J Am Chem Soc 74 4701 1952, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2573-2577 1961.]

References

[1] Patent: CN108440320, 2018, A. Location in patent: Paragraph 0033; 0035; 0043

L-Isovaline Preparation Products And Raw materials

Raw materials

Preparation Products

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L-Isovaline Suppliers

China 97 Germany 3 India 2 Japan 1 United Kingdom 3 United States 15 Global 121
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View Lastest Price from L-Isovaline manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
L-Isovaline 595-40-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-12
Career Henan Chemical Co
Product
L-Isovaline 595-40-4
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-22

595-40-4, L-IsovalineRelated Search:

ALTRENOGEST 4-Aminobutyric acid MCPB 2,2-Bis(hydroxymethyl)butyric acid Valine Glycine 2-Methyl butyric acid 6-Aminocaproic acid N,N-Dimethyl-1,4-phenylenediamine H-PHE-TRP-OH L-KYNURENINE (S)-2-Amino-2-methyl-butyric acid hydrochloride Tris(hydroxymethyl)aminomethane (R)-2-Amino-2-methyl-4-pentenoic acid 1-TERT-BUTOXYCARBONYLAMINO-CYCLOHEXANECARBOXYLIC ACID Dimethyl methyldopa S-(-)-Carbidopa ALPHA-METHYL-L-P-TYROSINE

  • L(+)-Isovaline Monohydrate
  • 2,3-Dimethylalanine
  • 2-azanyl-2-methyl-butanoic acid
  • L(+)-Isovaline Monohydrate, (>99% ee), 99+% 250MG
  • (S)-Α-ETHYLALANINE·H<SUB>2<SUB>O
  • α-Me-Gly(Ethyl)-OH·H<sub>2<sub>O
  • (S)-2-Amino-2-Methylbutanoic Acid
  • (S)-(+)-2-Amino-2-methylbutanoicacidmonohydrate(e.e.)
  • (S)-(+)-2-AMINO-2-METHYLBUTANOIC ACID 1-HYDRATE (E.E.)
  • (S)-(+)-2-Amino-2-methylbutanoic acid monohydrate
  • (R)-2-AMINO-2-METHYLBUTYRIC ACID
  • L-Isovaline
  • L-ISO-VALINE((S)-2-AMINO-2-METHYLBUTANOIC ACID)
  • (S)-alpha-Ethylalanine (>98%, >99%ee)
  • H-alpha-Et-D-Ala-OH
  • α-Me-Gly(Ethyl)-OH·H2O
  • (2S)-2-amino-2-methylbutanoic acid
  • 2-(4-ethoxyanilino)-6-(hydroxymethyl)oxane-3,4,5-triol
  • L-isovaline, >97%
  • L-Isovaline USP/EP/BP
  • a-Me-Gly(Ethyl)-OH
  • NSC 1019
  • NSC1019
  • NSC-1019
  • Isovaline L-
  • (S)-α-Ethylalanine?H2O
  • (S)-a-Ethylalanine·H2O
  • 595-40-4
  • 1400942-35-3
  • Amino Acid Derivatives
  • Valine [Val, V]
  • unnatural amino acids
  • pharmacetical
  • α-Methyl Amino Acids