3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE
- Product Name
- 3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE
- CAS No.
- 335165-68-9
- Chemical Name
- 3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE
- Synonyms
- BAX CHANNEL BLOCKER;Bax channel blocke;)-3-(piperazin-1-yL;Baxchannelblocker2HCl;BAI1 (Bax channel blocker);1-(3,6-Dibromo-9H-carbazoL;Bax channel blocker(BAI-1);9H-Carbazole-9-ethanol, 3,6-dibromo-α-(1-piperazinylmethyl)-;1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol;"(+/-)-1-(3,6-dibromocarbazol-9-yl)-3-piperazin-1-ylpropan-2-ol"
- CBNumber
- CB6143286
- Molecular Formula
- C19H21Br2N3O
- Formula Weight
- 467.2
- MOL File
- 335165-68-9.mol
3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE Property
- Boiling point:
- 388.1±42.0 °C(Predicted)
- Density
- 1.71±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- ≥28.2 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O
- form
- solid
- pka
- 14.48±0.20(Predicted)
- color
- White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- J64257
- Product name
- Bax Channel Blocker
- Packaging
- 10mg
- Price
- $151
- Updated
- 2021/12/16
- Product number
- 2160
- Product name
- Bax Channel Blocker
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $195
- Updated
- 2021/12/16
- Product number
- 2160
- Product name
- Bax Channel Blocker
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $818
- Updated
- 2021/12/16
- Product number
- 254714
- Product name
- Bax channel blocker
- Packaging
- 10mg
- Price
- $446
- Updated
- 2021/12/16
- Product number
- KIN0001067
- Product name
- BAX CHANNEL BLOCKER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.81
- Updated
- 2021/12/16
3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE Chemical Properties,Usage,Production
Uses
Bax channel blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome c release.
Biological Activity
Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC 50 = 0.52 μ M). Suggested to inhibit Bax channel formation/activity.
in vitro
bax channel blocker, a 3,6-dibromocarbazole derivative, was observed to inhibit cytochrome c releasing from mitochondria by bax channel modulation. the monohydroxy analogue bax channel blocker remained the unprecedented inhibition of bax-induced cytochrome c release at 10 μm. the ic50 value of bax channel blocker was determined to be 0.52 μm, indicating that bax channel blocker was a bax channel inhibitor as hypothesized. moreover, in the liposome assay, bax channel blocker showing significant inhibition (>65%) of cytochrome c release at 10 μm also demonstrated sub-micromolar ic50 value [1].
IC 50
0.52 μm in bax assay
References
[1] bombrun a,gerber p,casi g,terradillos o,antonsson b,halazy s. 3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via bax channel modulation. j med chem.2003 oct 9;46(21):4365-8.
3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE Suppliers
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