5-Bromo-1-methyl-1H-indole
- Product Name
- 5-Bromo-1-methyl-1H-indole
- CAS No.
- 10075-52-2
- Chemical Name
- 5-Bromo-1-methyl-1H-indole
- Synonyms
- CHEMBRDG-BB 9072049;N-Methyl-5-bromoindole;1-methyl-5-bromoindole;5-BROMO-1-METHYL-INDOLE;5-Bromo-1-methy-1H-indole;5-BROMO-1-METHYL-1H-INDOLE;5-Bromo-1-methylindole 97%;1H-Indole,5-bromo-1-methyl-;5-
Bromo- 1- methylindole;5-bromo-1-methyl-1H-indole(SALTDATA: FREE) - CBNumber
- CB7783698
- Molecular Formula
- C9H8BrN
- Formula Weight
- 210.07
- MOL File
- 10075-52-2.mol
5-Bromo-1-methyl-1H-indole Property
- Melting point:
- 43 °C
- Boiling point:
- 300.9±15.0 °C(Predicted)
- Density
- 1.47±0.1 g/cm3(Predicted)
- Flash point:
- >110℃
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C9H8BrN/c1-11-5-4-7-6-8(10)2-3-9(7)11/h2-6H,1H3
- InChIKey
- SBOITLSQLQGSLO-UHFFFAOYSA-N
- SMILES
- N1(C)C2=C(C=C(Br)C=C2)C=C1
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-36/37/38-41-37/38
- Safety Statements
- 22-26-36/37/39-39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 718300
- Product name
- 5-Bromo-1-methylindole
- Purity
- 97%
- Packaging
- 5g
- Price
- $200
- Updated
- 2023/06/20
- Product number
- B5263
- Product name
- 5-Bromo-1-methyl-1H-indole
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $40
- Updated
- 2025/07/31
- Product number
- B5263
- Product name
- 5-Bromo-1-methyl-1H-indole
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $119
- Updated
- 2025/07/31
- Product number
- B697293
- Product name
- 5-Bromo-1-methyl-1H-indole
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B697293
- Product name
- 5-Bromo-1-methyl-1H-indole
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
5-Bromo-1-methyl-1H-indole Chemical Properties,Usage,Production
Synthesis
10075-50-0
74-88-4
10075-52-2
1. 5-bromo-1H-indole (2.08 g, 10.6 mmol) was dissolved in 35 mL of DMF at 0 °C. 2. Sodium hydride (60% dispersed in mineral oil, 467 mg, 11.67 mmol) was added to the above solution, keeping the reaction temperature at 0 °C. 3. After stirring for 30 min, iodomethane (663 μL, 10.6 mmol) was slowly added. 4. The reaction mixture was gradually warmed to room temperature and stirring was continued for 10 min. 5. Upon completion of the reaction, the reaction was quenched with ice water at 0 °C. The reaction was then quenched with ice water. 6. The reaction mixture was extracted with ethyl acetate (3 × appropriate amount). 7. 7. The organic phases were combined, dried over anhydrous magnesium sulfate, filtered and concentrated. 8. The product was purified by fast column chromatography (eluent: 10% ethyl acetate/hexane) to give 5-bromo-1-methyl-1H-indole (2.16 g, 97% yield). 9. The product was analyzed by 1H NMR. 9. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.74 (d, J = 1.6 Hz, 1H), 7.30 (dd, J = 8.4, 2.0 Hz, 1H), 7.19 (d, J = 8.8 Hz, 1H), 7.05 (d, J = 3.2 Hz, 1H), 6.42 (d, J = 2.8 Hz, 1H), 3.78 (s, 3H), 6.42 (d, J = 2.8 Hz, 1H) 3.78 (s, 3H).
References
[1] Chemistry Letters, 1991, # 7, p. 1125 - 1128
[2] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 3, p. 333 - 336
[3] Organic Letters, 2015, vol. 17, # 2, p. 254 - 257
[4] Patent: WO2016/114816, 2016, A1. Location in patent: Paragraph 0332
[5] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 12, p. 4524 - 4529
5-Bromo-1-methyl-1H-indole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-1-methyl-1H-indole manufacturers
- Product
- 5-Bromo-1-methyl-1H-indole 10075-52-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-01