ChemicalBook > CAS DataBase List > 2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE

2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE

Product Name
2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE
CAS No.
299442-43-6
Chemical Name
2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE
Synonyms
NKY80;AKOS B003518;VITAS-BB TBB000019;SALOR-INT L203769-1EA;NKY 80, adenylyl cyclase 5 inhibitor;Adenylyl Cyclase Type V Inhibitor, NKY80;2-amino-7-(2-furyl)-7,8-dihydroquinazolin-5(6H)-one;2-AMINO-7-(FURANYL)-7,8-DIHYDRO-5(6H)-QUINAZOLINONE;2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE;2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone
CBNumber
CB6144364
Molecular Formula
C12H11N3O2
Formula Weight
229.23
MOL File
Mol file
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2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE Property

Boiling point:
464.9±47.0 °C(Predicted)
Density 
1.360±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO or methanol
form 
powder
pka
1.85±0.40(Predicted)
color 
off-white to light brown
Sensitive 
Light Sensitive
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
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Safety

Hazard Codes 
Xi,T
Risk Statements 
25
Safety Statements 
45
WGK Germany 
3
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
116850
Product name
Adenylyl Cyclase Type V Inhibitor, NKY80
Packaging
5mg
Price
$99.4
Updated
2024/03/01
Sigma-Aldrich
Product number
116850
Product name
Adenylyl Cyclase Type V Inhibitor, NKY80
Packaging
25mg
Price
$391
Updated
2023/06/20
Alfa Aesar
Product number
J64042
Product name
Adenylyl Cyclase Type V Inhibitor, NKY80
Packaging
5mg
Price
$112
Updated
2023/06/20
Cayman Chemical
Product number
17777
Product name
NKY80
Purity
≥98%
Packaging
10mg
Price
$138
Updated
2024/03/01
Cayman Chemical
Product number
17777
Product name
NKY80
Purity
≥98%
Packaging
5mg
Price
$71
Updated
2023/06/20
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2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE Chemical Properties,Usage,Production

Description

NKY-80 (299442-43-6) is a potent and selective adenylyl cyclase inhibitor. Selective for AC5 and over AC3 and AC2 (IC50 = 8.3 μM, 132 μM and 1.7 mM respectively).1,2 More recently shown to indiscriminately inhibit AC6.3 NKY-80 is an extremely useful tool for probing the involvement of adenylyl cyclases in cellular signaling.4

Uses

NKY 80 is an inhibitor of adenylyl cyclase (AC) and displays a greater affinity for AC5 over AC3 and AC2. Adenyl cyclase inhibitors can be easily modified by tumor targeting structures.

General Description

A cell-permeable quinazolinone containing a non-nucleoside compound that acts as a potent, selective inhibitor of adenylyl cyclase (AC) type V isoform (IC50 = 8.3 μM, 132 μM and 1.7 mM for type V, III and II, respectively) in the presence of Gsα GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Regulates the AC catalytic activity in heart and lung tissues.

Biochem/physiol Actions

Cell permeable: yes

storage

Store at +4°C

References

1) Onda?et al. (2001),?Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms; J. Biol. Chem.,?276?47785 2) Pierre?et al. (2009),?Capturing adenylyl cyclases as potential drug targets; Nat. Rev. Drug Discov.,?8?321 3) Brand?et al. (2013),?Isoform selectivity of adenylyl cyclase inhibitor: characterization of known and novel compounds; J. Pharmacol. Exp. Therap.,?347?265 4) Oritz-Capisano?et al. (2007),?Adenylyl cyclase isoform V mediates renin release from juxtaglomerular cells; Hypertension,?49?618

2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE Suppliers

China 56 Germany 1 Russia 2 United Kingdom 3 United States 13 USA 1 Global 76
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299442-43-6, 2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONERelated Search:

Mycophenolate mofetil ODQ ST034307

  • 2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone
  • Adenylyl Cyclase Type V Inhibitor, NKY80
  • 2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE
  • 2-AMINO-7-(FURANYL)-7,8-DIHYDRO-5(6H)-QUINAZOLINONE
  • AKOS B003518
  • SALOR-INT L203769-1EA
  • NKY80
  • VITAS-BB TBB000019
  • 2-amino-7-(2-furyl)-7,8-dihydroquinazolin-5(6H)-one
  • Adenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6 - Calbiochem
  • 5(6H)-Quinazolinone, 2-amino-7-(2-furanyl)-7,8-dihydro-
  • 2-Amino-7-(furan-2-yl)-7,8-dihydroquinazolin-5(6H)-one
  • NKY 80, adenylyl cyclase 5 inhibitor
  • 299442-43-6