ChemicalBook > CAS DataBase List > SESELIN

SESELIN

Product Name: SESELIN
CAS No.: 523-59-1
Chemical Name: SESELIN
Synonyms: Sesalin;Xie Hao Su;Seselin, 10 mM in DMSO;8,8-dimethylpyrano[2,3-h]chromen-2-one;8,8-dimethylpyrano[2,3-f]chromen-2-one;2,2-Dimethyl-1,5-dioxaphenanthrene-6(2H)-one;8,8-Dimethyl-2H,8H-pyrano[2,3-f]chromen-2-one;8,8-Dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-2-one;2H,8H-Benzo[1,2-b:3,4-b']dipyran-2-one, 8,8-dimethyl-
CBNumber: CB61444407
Molecular Formula: C14H12O3
Formula Weight: 228.24
MOL File: 523-59-1.mol

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SESELIN Property

Melting point:: 119-124 °C
Boiling point:: 403.0±45.0 °C(Predicted)
Density: 1.351 g/cm3(Temp: 18 °C)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: A solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29930
Product name: Seselin
Packaging: 1mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 29930
Product name: Seselin
Packaging: 5mg
Price: $456
Updated: 2024/03/01

TRC

Product number: S280650
Product name: Seselin
Packaging: 5mg
Price: $360
Updated: 2021/12/16

TRC

Product number: S280650
Product name: Seselin
Packaging: 10mg
Price: $685
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PXT0001956
Product name: SESELIN
Purity: 95.00%
Packaging: 5MG
Price: $496.49
Updated: 2021/12/16

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SESELIN Chemical Properties,Usage,Production

Uses

Seselin is a coumarin compound that can be isolated from the root bark of the Citropsis articulata plant. Studies show that Seselin might exhibit potential antimalarial activity and that its derivatives may exhibit antithrombotic activity.

Definition

ChEBI: A natural product found in Citropsis articulata.

Biological Activity

Seselin is an anti-inflammatory, anti-parasitic and antifungal pyrancoumarin found in anise and other plants. It appears th at seselin targets Jak2 to block the proinflammatory phenotype of macrophages in models of sepsis. Seselin down-regulates levels of proinflammatory factors and activity of STAT1 and p65 in models of sepsis.

in vivo

Seselin (0.5-40.5 mg/kg; s.c.; once) shows peripheral anti-inflammatory and antinociceptive activities in mice^[2].
Seselin (3-30 mg/kg; i.g.; once) ameliorates sepsis induced by caecal ligation and puncture in mice^[3].

Animal Model:	Male Swiss mice^[2]
Dosage:	0.5, 4.5 or 40.5 mg/kg
Administration:	Subcutaneous injection; once
Result:	Inhibited the writhing response induced by acetic acid in a significant and dose-dependent manner, by 19.5%, 26.2% and 41.4% at dose of 0.5, 4.5 or 40.5 mg/kg, respectively. Elicited a significant inhibition of formalin response during the second phase (inflammatory), by 90.3%, 97.8% and 95.3%, respectively.

Animal Model:	C57BL/6 mice, caecal ligation and puncture (CLP) induced sepsis model^[3]
Dosage:	3, 10 and 30 mg/kg
Administration:	Intragastric administration, once
Result:	Ameliorated lung injury and decreased JAK2 phosphorylation level in lung tissue during sepsis. Reduced the immune cell counts in BALF induced by CLP.

SESELIN Preparation Products And Raw materials

Raw materials

Preparation Products

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523-59-1, SESELINRelated Search:

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2,2-Dimethyl-1,5-dioxaphenanthrene-6(2H)-one

8,8-Dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-2-one

8,8-dimethylpyrano[2,3-h]chromen-2-one

2H,8H-Benzo[1,2-b:3,4-b']dipyran-2-one, 8,8-dimethyl-

Sesalin

8,8-dimethylpyrano[2,3-f]chromen-2-one

8,8-Dimethyl-2H,8H-pyrano[2,3-f]chromen-2-one

Seselin, 10 mM in DMSO

Xie Hao Su

523-59-1

523-29-1