2,4-dichloro-6-(trifluoromethyl)pyrimidine

Product Name: 2,4-dichloro-6-(trifluoromethyl)pyrimidine
CAS No.: 16097-64-6
Chemical Name: 2,4-dichloro-6-(trifluoromethyl)pyrimidine
Synonyms: 4-Dichloro-6-(trifluoromethyl)pyrimidine;2,4-dichloro-6-(trifluoromethyl)pyrimidine;2,4-Dichloro-6-(trifluoromethyl)-1,3-diazine;PyriMidine, 2,4-dichloro-6-(trifluoroMethyl)-;2,4-Dichloro-6-(trifluoromethyl)pyrimidine 98%;2,4-dichloro-6-(trifluoromethyl)pyrimidine ISO 9001：2015 REACH
CBNumber: CB61456459
Molecular Formula: C5HCl2F3N2
Formula Weight: 216.98
MOL File: 16097-64-6.mol

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2,4-dichloro-6-(trifluoromethyl)pyrimidine Property

Melting point:: -48--46 °C
Boiling point:: 37-38 °C(Press: 0.7 Torr)
Density: 1.589
refractive index: 1.4640
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -7.56±0.32(Predicted)
form: Liquid
color: Pale yellow
InChI: InChI=1S/C5HCl2F3N2/c6-3-1-2(5(8,9)10)11-4(7)12-3/h1H
InChIKey: ZTNFYAJHLPMNSN-UHFFFAOYSA-N
SMILES: C1(Cl)=NC(C(F)(F)F)=CC(Cl)=N1

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Safety

HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: D435445
Product name: 2,4-Dichloro-6-trifluoromethylpyrimidine
Packaging: 2.5g
Price: $250
Updated: 2021/12/16

TRC

Product number: D435445
Product name: 2,4-Dichloro-6-trifluoromethylpyrimidine
Packaging: 10g
Price: $800
Updated: 2021/12/16

AK Scientific

Product number: J54558
Product name: 2,4-Dichloro-6-(trifluoromethyl)pyrimidine
Packaging: 1g
Price: $12
Updated: 2021/12/16

AK Scientific

Product number: W3492
Product name: 2,4-Dichloro-6-(trifluoromethyl)pyrimidine
Packaging: 1g
Price: $17
Updated: 2021/12/16

Matrix Scientific

Product number: 073216
Product name: 2,4-Dichloro-6-(trifluoromethyl)pyrimidine
Purity: 95+%
Packaging: 5g
Price: $38
Updated: 2021/12/16

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2,4-dichloro-6-(trifluoromethyl)pyrimidine Chemical Properties,Usage,Production

Uses

2,4-Dichloro-6-trifluoromethylpyrimidine is a useful synthetic intermediate. It can be used to synthesize 2,4-diaminopyrimidines derivatives that show antiplasmodial activities.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 24, p. 1243, 1987 DOI: 10.1002/jhet.5570240502

Synthesis

672-45-7

16097-64-6

Synthesis of 2,4-dichloro-6-trifluoromethylpyrimidine (XXVII): 6-(trifluoromethyl)uracil (XXVI) (10.0 g, 55 mmol) was dissolved in anhydrous acetonitrile (50 mL) under dry conditions. Subsequently, N,N-dimethylaniline (6.5 mL, 51 mmol) and phosphorus oxychloride (POCl3) (19 mL, 204 mmol) were added sequentially to the reaction system. Almost complete dissolution of the solids was observed, forming a dark colored solution. The reaction mixture was heated to reflux and the reflux reaction was maintained for 6 hours. Upon completion of the reaction, the heating was stopped and the volatile components were removed under reduced pressure. The residue was dissolved in ether (Et2O) (300 mL), the resulting ether solution was washed sequentially with deionized water (2 x 200 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated to give 2,4-dichloro-6-trifluoromethylpyrimidine (XXVII) as a yellow oil (11.3 g, 94% yield). The product was characterized by 1H NMR (CDCl3): δ 7.7 (s, 1H); GC/MS analysis showed m/z (relative abundance) 220 (12), 218 (67), 216 (100).

References

[1] Patent: US2009/93480, 2009, A1. Location in patent: Page/Page column 6-7
[2] Patent: WO2016/42452, 2016, A1. Location in patent: Page/Page column 114; 115
[3] Patent: WO2016/42453, 2016, A1. Location in patent: Page/Page column 51
[4] European Journal of Organic Chemistry, 2006, # 6, p. 1593 - 1598
[5] Patent: WO2015/191630, 2015, A1. Location in patent: Paragraph 00398

2,4-dichloro-6-(trifluoromethyl)pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,4-dichloro-6-(trifluoromethyl)pyrimidine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2,4-Dichloro-6-trifluoromethylpyrimidine 16097-64-6
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-17

Dideu Industries Group Limited

Product: 2,4-dichloro-6-(trifluoromethyl)pyrimidine 16097-64-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-06

Career Henan Chemical Co

Product: 2,4-dichloro-6-(trifluoromethyl)pyrimidine 16097-64-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KGS
Release date: 2020-01-02

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2,4-dichloro-6-(trifluoromethyl)pyrimidine ISO 9001：2015 REACH

16097-64-6

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