2,4-Dichloro-5-trifluoromethylpyrimidine
- Product Name
- 2,4-Dichloro-5-trifluoromethylpyrimidine
- CAS No.
- 3932-97-6
- Chemical Name
- 2,4-Dichloro-5-trifluoromethylpyrimidine
- Synonyms
- 2,4-DICHLORO-5-(TRIFLUOROMETHYL)PYRIMIDINE;PyriMidine, 2,4-dichloro-5-(trifluoroMethyl)-;2,4-Dichloro-5-trifl;4-Dichloro-5-(trifluoroMethyl);2,4-Dichloro-5-(trifluoroMethyl);4-(broMoMethyl)-3-chlorobenzaMide;5-TRIFLUOROMETHYL-2,4-DICHLOROPYRIMIDINE;2,6-Dichloro-5-trifluoromethylpyrimidine;2,4-Dichloro-5-(trifluoromethyl)-1,3-diazine;2,4-Dichloro-5-(trifluoroMethyl)pyriMidine 97%
- CBNumber
- CB4237271
- Molecular Formula
- C5HCl2F3N2
- Formula Weight
- 216.98
- MOL File
- 3932-97-6.mol
2,4-Dichloro-5-trifluoromethylpyrimidine Property
- Boiling point:
- 49℃/32mm
- Density
- 1.609 g/mL at 25 °C
- refractive index
- 1.4749
- Flash point:
- 200 ºF
- storage temp.
- 2-8°C
- solubility
- Chloroform, Methanol
- form
- Clear Colorless to Pale Yellow Liquid
- pka
- -4.89±0.29(Predicted)
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C5HCl2F3N2/c6-3-2(5(8,9)10)1-11-4(7)12-3/h1H
- InChIKey
- VABVSVZAESMOCH-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(C(F)(F)F)C(Cl)=N1
- CAS DataBase Reference
- 3932-97-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,C,T
- Risk Statements
- 36/37/38-36-25
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 2810
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- CORROSIVE
- HazardClass
- 8
- PackingGroup
- Ⅲ
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 684864
- Product name
- 2,4-Dichloro-5-(trifluoromethyl)pyrimidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $66.23
- Updated
- 2025/07/31
- Product number
- 684864
- Product name
- 2,4-Dichloro-5-(trifluoromethyl)pyrimidine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $40.3
- Updated
- 2023/06/20
- Product number
- D5980
- Product name
- 2,4-Dichloro-5-(trifluoromethyl)pyrimidine
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $68
- Updated
- 2025/07/31
- Product number
- D5980
- Product name
- 2,4-Dichloro-5-(trifluoromethyl)pyrimidine
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $203
- Updated
- 2025/07/31
- Product number
- D436635
- Product name
- 2,4-Dichloro-5-trifluoromethylpyrimidine
- Packaging
- 10g
- Price
- $120
- Updated
- 2021/12/16
2,4-Dichloro-5-trifluoromethylpyrimidine Chemical Properties,Usage,Production
Chemical Properties
White liquid or solid
Uses
2,4-Dichloro-5-trifluoromethylpyrimidine is a reactant in the preparation of pyrimidine derivatives as inhibitors of gene ALK protein Kinase phosphorylating kinase and as cell proliferation inhibitors.
Synthesis
54-20-6
3932-97-6
The general procedure for the synthesis of 2,4-dichloro-5-trifluoromethylpyrimidine from 5-trifluoromethyluracil is as follows: 1. 5-Trifluoromethyluracil (250 g, 1.39 mol) and phosphorus trichloride (655 mL, 6.94 mol, 5 eq.) were added to a 3L four-neck flask fitted with an overhead stirrer, a reflux condenser, a dosing funnel, and an internal thermocouple under nitrogen protection. 2. concentrated phosphoric acid (85 wt%, 9.5 mL, 0.1 eq.) was added to the reaction mixture in a single addition and a moderate exothermic phenomenon was observed. 3. Diisopropylethylamine (245 mL, 1.39 mol, 1 eq.) was added slowly dropwise over 15 minutes, controlling the dropwise acceleration so that the internal temperature of the reaction reached 85-90 °C at the end of the dropwise acceleration. Upon completion of the dropwise addition, the reaction mixture changed to a homogeneous light orange solution. 4. The reaction mixture was heated to 100 °C and held for 20 hours until HPLC analysis showed complete consumption of the feedstock. 5. The heating was stopped and the reaction mixture was cooled to 40 °C and then slowly added dropwise to a pre-cooled mixture of 3N HCl (5 L, 10 eq.) and ether (2 L), maintaining the temperature of the quench tank. 6. Separate the organic and aqueous layers, the aqueous layer being extracted once with ether (1 L). The organic layers were combined and washed with water until the washings were neutral (5 times, 1.5 L each), then dried over MgSO4 and concentrated to give 288 g (95% yield) of a light yellow-orange oily product with 96% HPLC purity. 7. The product can be extracted under reduced pressure from aqueous solution of 1.5 L of ether (2 L). 7. The product was further purified by reduced pressure distillation (boiling point 109 °C, 79 mmHg).
References
[1] Patent: US2005/256145, 2005, A1. Location in patent: Page/Page column 43
[2] Patent: US2005/256125, 2005, A1. Location in patent: Page/Page column 29
[3] Patent: US2005/256144, 2005, A1. Location in patent: Page/Page column 20
[4] Patent: US2014/135497, 2014, A1. Location in patent: Paragraph 0060; 0061; 0062; 0063; 0064
[5] Patent: WO2014/76085, 2014, A1. Location in patent: Page/Page column 9-10
2,4-Dichloro-5-trifluoromethylpyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Dichloro-5-trifluoromethylpyrimidine manufacturers
- Product
- 2,4-Dichloro-5-trifluoromethylpyrimidine 3932-97-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- 2,4-Dichloro-5-trifluoromethyl-pyrimidine 3932-97-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 100kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2025-03-11
- Product
- 2,4-Dichloro-5-trifluoromethylpyrimidine 3932-97-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-19