ChemicalBook > CAS DataBase List > 2,4-Dichloro-5-trifluoromethylpyrimidine

2,4-Dichloro-5-trifluoromethylpyrimidine

Product Name: 2,4-Dichloro-5-trifluoromethylpyrimidine
CAS No.: 3932-97-6
Chemical Name: 2,4-Dichloro-5-trifluoromethylpyrimidine
Synonyms: 2,4-DICHLORO-5-(TRIFLUOROMETHYL)PYRIMIDINE;PyriMidine, 2,4-dichloro-5-(trifluoroMethyl)-;2,4-Dichloro-5-trifl;4-Dichloro-5-(trifluoroMethyl);2,4-Dichloro-5-(trifluoroMethyl);4-(broMoMethyl)-3-chlorobenzaMide;5-TRIFLUOROMETHYL-2,4-DICHLOROPYRIMIDINE;2,6-Dichloro-5-trifluoromethylpyrimidine;2,4-Dichloro-5-(trifluoromethyl)-1,3-diazine;2,4-Dichloro-5-(trifluoroMethyl)pyriMidine 97%
CBNumber: CB4237271
Molecular Formula: C5HCl2F3N2
Formula Weight: 216.98
MOL File: 3932-97-6.mol

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2,4-Dichloro-5-trifluoromethylpyrimidine Property

Boiling point:: 49℃/32mm
Density: 1.609 g/mL at 25 °C
refractive index: 1.4749
Flash point:: 200 ºF
storage temp.: 2-8°C
solubility: Chloroform, Methanol
form: Clear Colorless to Pale Yellow Liquid
pka: -4.89±0.29(Predicted)
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C5HCl2F3N2/c6-3-2(5(8,9)10)1-11-4(7)12-3/h1H
InChIKey: VABVSVZAESMOCH-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(C(F)(F)F)C(Cl)=N1
CAS DataBase Reference: 3932-97-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,C,T
Risk Statements: 36/37/38-36-25
Safety Statements: 26-36/37/39-45
RIDADR: UN 2810
WGK Germany: 3
Hazard Note: Irritant
HazardClass: CORROSIVE
HazardClass: 8
PackingGroup: Ⅲ
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 684864
Product name: 2,4-Dichloro-5-(trifluoromethyl)pyrimidine
Purity: 97%
Packaging: 1g
Price: $66.23
Updated: 2025/07/31

Sigma-Aldrich

Product number: 684864
Product name: 2,4-Dichloro-5-(trifluoromethyl)pyrimidine
Purity: 97%
Packaging: 250mg
Price: $40.3
Updated: 2023/06/20

TCI Chemical

Product number: D5980
Product name: 2,4-Dichloro-5-(trifluoromethyl)pyrimidine
Purity: min. 98.0 %
Packaging: 1G
Price: $68
Updated: 2025/07/31

TCI Chemical

Product number: D5980
Product name: 2,4-Dichloro-5-(trifluoromethyl)pyrimidine
Purity: min. 98.0 %
Packaging: 5G
Price: $203
Updated: 2025/07/31

TRC

Product number: D436635
Product name: 2,4-Dichloro-5-trifluoromethylpyrimidine
Packaging: 10g
Price: $120
Updated: 2021/12/16

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2,4-Dichloro-5-trifluoromethylpyrimidine Chemical Properties,Usage,Production

Chemical Properties

White liquid or solid

Uses

2,4-Dichloro-5-trifluoromethylpyrimidine is a reactant in the preparation of pyrimidine derivatives as inhibitors of gene ALK protein Kinase phosphorylating kinase and as cell proliferation inhibitors.

Synthesis

54-20-6

3932-97-6

The general procedure for the synthesis of 2,4-dichloro-5-trifluoromethylpyrimidine from 5-trifluoromethyluracil is as follows: 1. 5-Trifluoromethyluracil (250 g, 1.39 mol) and phosphorus trichloride (655 mL, 6.94 mol, 5 eq.) were added to a 3L four-neck flask fitted with an overhead stirrer, a reflux condenser, a dosing funnel, and an internal thermocouple under nitrogen protection. 2. concentrated phosphoric acid (85 wt%, 9.5 mL, 0.1 eq.) was added to the reaction mixture in a single addition and a moderate exothermic phenomenon was observed. 3. Diisopropylethylamine (245 mL, 1.39 mol, 1 eq.) was added slowly dropwise over 15 minutes, controlling the dropwise acceleration so that the internal temperature of the reaction reached 85-90 °C at the end of the dropwise acceleration. Upon completion of the dropwise addition, the reaction mixture changed to a homogeneous light orange solution. 4. The reaction mixture was heated to 100 °C and held for 20 hours until HPLC analysis showed complete consumption of the feedstock. 5. The heating was stopped and the reaction mixture was cooled to 40 °C and then slowly added dropwise to a pre-cooled mixture of 3N HCl (5 L, 10 eq.) and ether (2 L), maintaining the temperature of the quench tank. 6. Separate the organic and aqueous layers, the aqueous layer being extracted once with ether (1 L). The organic layers were combined and washed with water until the washings were neutral (5 times, 1.5 L each), then dried over MgSO4 and concentrated to give 288 g (95% yield) of a light yellow-orange oily product with 96% HPLC purity. 7. The product can be extracted under reduced pressure from aqueous solution of 1.5 L of ether (2 L). 7. The product was further purified by reduced pressure distillation (boiling point 109 °C, 79 mmHg).

References

[1] Patent: US2005/256145, 2005, A1. Location in patent: Page/Page column 43
[2] Patent: US2005/256125, 2005, A1. Location in patent: Page/Page column 29
[3] Patent: US2005/256144, 2005, A1. Location in patent: Page/Page column 20
[4] Patent: US2014/135497, 2014, A1. Location in patent: Paragraph 0060; 0061; 0062; 0063; 0064
[5] Patent: WO2014/76085, 2014, A1. Location in patent: Page/Page column 9-10

2,4-Dichloro-5-trifluoromethylpyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,4-Dichloro-5-trifluoromethylpyrimidine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2,4-Dichloro-5-trifluoromethylpyrimidine 3932-97-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Jiangsu Liyang Kunlun Biological Technology Co., Ltd.

Product: 2,4-Dichloro-5-trifluoromethyl-pyrimidine 3932-97-6
Price: US $0.00-0.00/kg
Min. Order: 100kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2025-03-11

Shaanxi Dideu New Materials Co. Ltd

Product: 2,4-Dichloro-5-trifluoromethylpyrimidine 3932-97-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-19

3932-97-6, 2,4-Dichloro-5-trifluoromethylpyrimidineRelated Search:

4,6-Dichloropyrimidine 2,4-Dichloropyrimidine EMULSIFIER 4-Methoxybenzoic acid Carbon disulfide gentian root extract 2,4-dichloro-6-(trifluoromethyl)pyrimidine 2,4-Dichloro-5-methylpyrimidine Pyrimidine, 2-chloro-5-(trifluoromethyl)- (9CI) 2,4-Dichloro-5-trifluoromethylpyrimidine

2,4-DICHLORO-5-(TRIFLUOROMETHYL)PYRIMIDINE

5-TRIFLUOROMETHYL-2,4-DICHLOROPYRIMIDINE

4-(broMoMethyl)-3-chlorobenzaMide

2,4-Dichloro-5-(trifluoromethyl)-1,3-diazine

2,4-Dichloro-5-(trifluoroMethyl)pyriMidine 97%

2,4-Dichloro-5-(trifluoroMethyl)

PyriMidine, 2,4-dichloro-5-(trifluoroMethyl)-

2,4-Dichloro-5-trifl

2,4-Dichloro-5-trifluoromethylpyrimidine 5-Trifluoromethyl-2,4-dichloropyrimidine

4-Dichloro-5-(trifluoroMethyl)

2,4-Dichloro-5-trifluoromethylpyrimidine ISO 9001：2015 REACH

2,6-Dichloro-5-trifluoromethylpyrimidine

3932-97-6

3923-97-6

3933-97-6

C5HCl2F3N2

Pyrazoles

Fluorine series

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyrimidines

pharmacetical

Pyrimidine

Building Blocks

Halogenated

3932-97-6