ChemicalBook > CAS DataBase List > 2,4-Dichloro-5-trifluoromethylpyrimidine

2,4-Dichloro-5-trifluoromethylpyrimidine

Product Name
2,4-Dichloro-5-trifluoromethylpyrimidine
CAS No.
3932-97-6
Chemical Name
2,4-Dichloro-5-trifluoromethylpyrimidine
Synonyms
2,4-DICHLORO-5-(TRIFLUOROMETHYL)PYRIMIDINE;PyriMidine, 2,4-dichloro-5-(trifluoroMethyl)-;2,4-Dichloro-5-trifl;4-Dichloro-5-(trifluoroMethyl);2,4-Dichloro-5-(trifluoroMethyl);4-(broMoMethyl)-3-chlorobenzaMide;5-TRIFLUOROMETHYL-2,4-DICHLOROPYRIMIDINE;2,6-Dichloro-5-trifluoromethylpyrimidine;2,4-Dichloro-5-(trifluoromethyl)-1,3-diazine;2,4-Dichloro-5-(trifluoroMethyl)pyriMidine 97%
CBNumber
CB4237271
Molecular Formula
C5HCl2F3N2
Formula Weight
216.98
MOL File
3932-97-6.mol
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2,4-Dichloro-5-trifluoromethylpyrimidine Property

Boiling point:
49℃/32mm
Density 
1.609 g/mL at 25 °C
refractive index 
1.4749
Flash point:
200 ºF
storage temp. 
2-8°C
solubility 
Chloroform, Methanol
form 
Clear Colorless to Pale Yellow Liquid
pka
-4.89±0.29(Predicted)
Appearance
Colorless to light yellow Liquid
InChI
InChI=1S/C5HCl2F3N2/c6-3-2(5(8,9)10)1-11-4(7)12-3/h1H
InChIKey
VABVSVZAESMOCH-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C(C(F)(F)F)C(Cl)=N1
CAS DataBase Reference
3932-97-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,C,T
Risk Statements 
36/37/38-36-25
Safety Statements 
26-36/37/39-45
RIDADR 
UN 2810
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
CORROSIVE
HazardClass 
8
PackingGroup 
Ⅲ
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
684864
Product name
2,4-Dichloro-5-(trifluoromethyl)pyrimidine
Purity
97%
Packaging
1g
Price
$66.23
Updated
2025/07/31
Sigma-Aldrich
Product number
684864
Product name
2,4-Dichloro-5-(trifluoromethyl)pyrimidine
Purity
97%
Packaging
250mg
Price
$40.3
Updated
2023/06/20
TCI Chemical
Product number
D5980
Product name
2,4-Dichloro-5-(trifluoromethyl)pyrimidine
Purity
min. 98.0 %
Packaging
1G
Price
$68
Updated
2025/07/31
TCI Chemical
Product number
D5980
Product name
2,4-Dichloro-5-(trifluoromethyl)pyrimidine
Purity
min. 98.0 %
Packaging
5G
Price
$203
Updated
2025/07/31
TRC
Product number
D436635
Product name
2,4-Dichloro-5-trifluoromethylpyrimidine
Packaging
10g
Price
$120
Updated
2021/12/16
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2,4-Dichloro-5-trifluoromethylpyrimidine Chemical Properties,Usage,Production

Chemical Properties

White liquid or solid

Uses

2,4-Dichloro-5-trifluoromethylpyrimidine is a reactant in the preparation of pyrimidine derivatives as inhibitors of gene ALK protein Kinase phosphorylating kinase and as cell proliferation inhibitors.

Synthesis

54-20-6

3932-97-6

The general procedure for the synthesis of 2,4-dichloro-5-trifluoromethylpyrimidine from 5-trifluoromethyluracil is as follows: 1. 5-Trifluoromethyluracil (250 g, 1.39 mol) and phosphorus trichloride (655 mL, 6.94 mol, 5 eq.) were added to a 3L four-neck flask fitted with an overhead stirrer, a reflux condenser, a dosing funnel, and an internal thermocouple under nitrogen protection. 2. concentrated phosphoric acid (85 wt%, 9.5 mL, 0.1 eq.) was added to the reaction mixture in a single addition and a moderate exothermic phenomenon was observed. 3. Diisopropylethylamine (245 mL, 1.39 mol, 1 eq.) was added slowly dropwise over 15 minutes, controlling the dropwise acceleration so that the internal temperature of the reaction reached 85-90 °C at the end of the dropwise acceleration. Upon completion of the dropwise addition, the reaction mixture changed to a homogeneous light orange solution. 4. The reaction mixture was heated to 100 °C and held for 20 hours until HPLC analysis showed complete consumption of the feedstock. 5. The heating was stopped and the reaction mixture was cooled to 40 °C and then slowly added dropwise to a pre-cooled mixture of 3N HCl (5 L, 10 eq.) and ether (2 L), maintaining the temperature of the quench tank. 6. Separate the organic and aqueous layers, the aqueous layer being extracted once with ether (1 L). The organic layers were combined and washed with water until the washings were neutral (5 times, 1.5 L each), then dried over MgSO4 and concentrated to give 288 g (95% yield) of a light yellow-orange oily product with 96% HPLC purity. 7. The product can be extracted under reduced pressure from aqueous solution of 1.5 L of ether (2 L). 7. The product was further purified by reduced pressure distillation (boiling point 109 °C, 79 mmHg).

References

[1] Patent: US2005/256145, 2005, A1. Location in patent: Page/Page column 43
[2] Patent: US2005/256125, 2005, A1. Location in patent: Page/Page column 29
[3] Patent: US2005/256144, 2005, A1. Location in patent: Page/Page column 20
[4] Patent: US2014/135497, 2014, A1. Location in patent: Paragraph 0060; 0061; 0062; 0063; 0064
[5] Patent: WO2014/76085, 2014, A1. Location in patent: Page/Page column 9-10

2,4-Dichloro-5-trifluoromethylpyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Dichloro-5-trifluoromethylpyrimidine Suppliers

Canada 1 China 275 Europe 2 France 1 Germany 6 India 11 Japan 3 Switzerland 2 United Kingdom 11 United States 32 Global 344
Alfa Aesar
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Global Pharma Tek (GPT)
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Telangana Pharmatech
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ALTAIR ALCHEMY Laboratories
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A.J Chemicals
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View Lastest Price from 2,4-Dichloro-5-trifluoromethylpyrimidine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2,4-Dichloro-5-trifluoromethylpyrimidine 3932-97-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Jiangsu Liyang Kunlun Biological Technology Co., Ltd.
Product
2,4-Dichloro-5-trifluoromethyl-pyrimidine 3932-97-6
Price
US $0.00-0.00/kg
Min. Order
100kg
Purity
0.99
Supply Ability
20 tons
Release date
2025-03-11
Shaanxi Dideu New Materials Co. Ltd
Product
2,4-Dichloro-5-trifluoromethylpyrimidine 3932-97-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-02-19

3932-97-6, 2,4-Dichloro-5-trifluoromethylpyrimidineRelated Search:

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  • 5-TRIFLUOROMETHYL-2,4-DICHLOROPYRIMIDINE
  • 4-(broMoMethyl)-3-chlorobenzaMide
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  • 2,6-Dichloro-5-trifluoromethylpyrimidine
  • 3932-97-6
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  • C5HCl2F3N2
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  • 3932-97-6