4-Chloro-6-trifluoromethylpyrimidine

Product Name: 4-Chloro-6-trifluoromethylpyrimidine
CAS No.: 37552-81-1
Chemical Name: 4-Chloro-6-trifluoromethylpyrimidine
Synonyms: IFLAB-BB F2124-0884;4-chloro-6-trifluorMethylpyriMidine;4-CHLORO-6-TRIFLUOROMETHYLPYRIMIDINE;6-Chloro-4-(trifluoromethyl)pyrimidine;4-Chloro-6-(trifluoromethyl)-1,3-diazine;PYRIMIDINE, 4-CHLORO-6-(TRIFLUOROMETHYL)-;4-Chloro-6-(trifluoromethyl)pyrimidine,95%;4-CHLORO-6-(TRIFLUOROMETHYL)PYRIMIDINE ,98%;4-Chloro-6-trifluoromethylpyrimidine ISO 9001：2015 REACH
CBNumber: CB5178980
Molecular Formula: C5H2ClF3N2
Formula Weight: 182.53
MOL File: 37552-81-1.mol

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4-Chloro-6-trifluoromethylpyrimidine Property

Melting point:: -53--52 °C
Boiling point:: 35-36 °C(Press: 22 Torr)
Density: 1.429 g/cm3
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -4.62±0.18(Predicted)
form: Liquid
color: Colorless to pale yellow
InChI: InChI=1S/C5H2ClF3N2/c6-4-1-3(5(7,8)9)10-2-11-4/h1-2H
InChIKey: TYSPDLZOMUDHQZ-UHFFFAOYSA-N
SMILES: C1=NC(C(F)(F)F)=CC(Cl)=N1
CAS DataBase Reference: 37552-81-1(CAS DataBase Reference)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: C432985
Product name: 4-Chloro-6-trifluoromethylpyrimidine
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: C432985
Product name: 4-Chloro-6-trifluoromethylpyrimidine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC11928
Product name: 4-Chloro-6-trifluoromethylpyrimidine
Packaging: 1g
Price: $50
Updated: 2021/12/16

Matrix Scientific

Product number: 072267
Product name: 4-Chloro-6-(trifluoromethyl)pyrimidine
Purity: 95+%
Packaging: 5g
Price: $54
Updated: 2021/12/16

Oakwood

Product number: 032772
Product name: 4-Chloro-6-trifluoromethylpyrimidine
Purity: 98%
Packaging: 250mg
Price: $14
Updated: 2021/12/16

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4-Chloro-6-trifluoromethylpyrimidine Chemical Properties,Usage,Production

Synthesis

1546-78-7

37552-81-1

General procedure for the synthesis of 4-chloro-6-trifluoromethylpyrimidine from 6-trifluoromethyl-4-hydroxypyrimidine: 6-(trifluoromethyl)pyrimidin-4-ol (5.0 g, 30.5 mmol), phosphorochloridic acid chloride (3.41 mL, 36.6 mmol), and quinoline (2.16 mL, 18.3 mmol) were dissolved in toluene (50 mL), and the reaction was stirred at 100°C for 5 hours. After completion of the reaction, the reaction mixture was diluted with water and extracted three times with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography (eluent: 10% ethyl acetate/hexane) to afford the target product 4-chloro-6-trifluoromethylpyrimidine (1.20 g, 21.6% yield).1H NMR (400 MHz, CDCl3) δ: 9.21 ppm (1H, s), 7.78 ppm (1H, s).

References

[1] Patent: US2006/4018, 2006, A1. Location in patent: Page/Page column 39-40
[2] Patent: US2005/209241, 2005, A1. Location in patent: Page/Page column 26
[3] Patent: WO2015/17335, 2015, A1. Location in patent: Page/Page column 66
[4] Patent: US2015/197511, 2015, A1. Location in patent: Paragraph 0393; 0394
[5] Patent: WO2015/160654, 2015, A1. Location in patent: Page/Page column 144-145

4-Chloro-6-trifluoromethylpyrimidine Preparation Products And Raw materials

Raw materials

Ethyl 4,4,4-trifluoroacetoacetate Hexane Quinoline Ethanol Sodium sulfate Toluene Sodium Phosphorus oxitrichloride Formamidine hydrochloride Ethyl acetate Hydrochloric acid Methanol PETROLEUM ETHER

Preparation Products

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4-Chloro-6-trifluoromethylpyrimidine Suppliers

Canada 1 China 161 Germany 3 India 3 United Kingdom 7 United States 20 Global 195

Atop Bio-Tech (Tianjin) Co., Ltd. (Atop)

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J & K SCIENTIFIC LTD.

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Capot Chemical Co., Ltd

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Changzhou Huanling Chemical Co., Ltd.

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Jia Xing Isenchem Co.,Ltd

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Pure Chemistry Scientific Inc.

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Nanjing Chemlin Chemical Co., Ltd

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View Lastest Price from 4-Chloro-6-trifluoromethylpyrimidine manufacturers

Shanghai Rlavie Technology Co ltd

Product: 4-chloro-6-trifluormethyl pyrimidine 37552-81-1
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: 100kgs/month
Release date: 2022-01-03

Dideu Industries Group Limited

Product: 4-Chloro-6-trifluoromethylpyrimidine 37552-81-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-06

Career Henan Chemical Co

Product: 4-Chloro-6-trifluoromethylpyrimidine 37552-81-1
Price: US $1.00/KG
Min. Order: 100g
Purity: 98%
Supply Ability: 200KG
Release date: 2019-12-17

37552-81-1, 4-Chloro-6-trifluoromethylpyrimidineRelated Search:

Chloromethyltrimethylsilane Pyrimidine Trifluoromethanesulfonic acid 2-(Trifluoromethyl)benzoic acid 2-(Trifluoromethyl)benzyl chloride 2-Aminobenzotrifluoride Epichlorohydrin 3-(Trifluoromethyl)benzaldehyde Pirimiphos-methyl Chloroacetic acid Difluorochloromethane 4-CHLORO-2-(METHYLSULFANYL)-6-(TRIFLUOROMETHYL)PYRIMIDINE 2-AMINO-4-CHLORO-6-TRIFLUOROMETHYL-PYRIMIDINE Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate 2,4-dichloro-6-(trifluoromethyl)pyrimidine ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE 4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE 2-Chloro-4-(trifluoromethyl)pyrimidine

PYRIMIDINE, 4-CHLORO-6-(TRIFLUOROMETHYL)-

IFLAB-BB F2124-0884

4-CHLORO-6-TRIFLUOROMETHYLPYRIMIDINE

6-Chloro-4-(trifluoromethyl)pyrimidine

4-CHLORO-6-(TRIFLUOROMETHYL)PYRIMIDINE ,98%

4-chloro-6-trifluorMethylpyriMidine

4-Chloro-6-(trifluoromethyl)-1,3-diazine

4-Chloro-6-(trifluoromethyl)pyrimidine,95%

4-Chloro-6-trifluoromethylpyrimidine ISO 9001：2015 REACH

37552-81-1

67552-81-1

Pyrimidine

Boronic Acid

Heterocyclic Compounds

Pyrimidines

Pyrimidine series

Fluorine series

alkyl chloride