ChemicalBook > CAS DataBase List > 3-Chloro-4-(3-fluorobenzyloxy)aniline

3-Chloro-4-(3-fluorobenzyloxy)aniline

Product Name
3-Chloro-4-(3-fluorobenzyloxy)aniline
CAS No.
202197-26-0
Chemical Name
3-Chloro-4-(3-fluorobenzyloxy)aniline
Synonyms
oxy)aniL;oro-4-(3-fL;LAPATINIB IMP A;Compound PDK0113;Lapatinib impurity A;Lapatinib Impurity 18-d4;3-Chloro-4-((3-fluorobenzyl);Lapatinib genotoxic impurity 1;3-Chloro-4-(3-fluorobenzyloxy)-anilin;4-(3-Fluorobenzyloxy)- 3-chloroaniline
CBNumber
CB61456989
Molecular Formula
C13H11ClFNO
Formula Weight
251.68
MOL File
202197-26-0.mol
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3-Chloro-4-(3-fluorobenzyloxy)aniline Property

Melting point:
78.0 to 82.0 °C
Boiling point:
387.9±32.0 °C(Predicted)
Density 
1.306±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Acetonitrile (Slightly), DMSO (Slightly), Methanol
form 
powder to crystal
pka
3.98±0.10(Predicted)
color 
White to Gray to Red
InChI
InChI=1S/C13H11ClFNO/c14-12-7-11(16)4-5-13(12)17-8-9-2-1-3-10(15)6-9/h1-7H,8,16H2
InChIKey
AYPFEYDGZDPAPE-UHFFFAOYSA-N
SMILES
C1(N)=CC=C(OCC2=CC=CC(F)=C2)C(Cl)=C1
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Safety

RIDADR 
3077
HazardClass 
9
PackingGroup 
III
HS Code 
29221990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS012378
Product name
3-chloro-4-(3-fluorobenzyloxy)aniline
Purity
Aldrich<SUP>CPR</SUP>
Packaging
100 mg
Price
$185
Updated
2025/07/31
TCI Chemical
Product number
C2874
Product name
3-Chloro-4-(3-fluorobenzyloxy)aniline
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$36
Updated
2025/07/31
TCI Chemical
Product number
C2874
Product name
3-Chloro-4-(3-fluorobenzyloxy)aniline
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$146
Updated
2025/07/31
TRC
Product number
C377650
Product name
3-Chloro-4-(3-fluorobenzyloxy)aniline
Packaging
1g
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC37254
Product name
3-Chloro-4-(3-fluorobenzyloxy)aniline
Packaging
1g
Price
$90
Updated
2021/12/16
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3-Chloro-4-(3-fluorobenzyloxy)aniline Chemical Properties,Usage,Production

Chemical Properties

Tan Solid

Uses

3-Chloro-4-(3-fluorobenzyloxy)aniline is an intermediate in the synthesis of Lapatinib (L175800).

Synthesis

443882-99-3

202197-26-0

Example 5: Preparation of 3-chloro-4-(3-fluorobenzyloxy)aniline In a 1 L reactor, 35.6 g of Intermediate-A (3-chloro-4-(3-fluorobenzyloxy)nitrobenzene), 21.2 g of iron powder (70 mesh), and 60.9 g of ammonium chloride were dissolved in a solvent mixture of 506 mL of ethanol and 128 mL of water, and the reaction was carried out at reflux for 2 hours. Upon completion of the reaction, the reaction mixture was cooled to 20-25 °C and the insoluble iron oxide was removed by vacuum filtration. The solid obtained by filtration was washed with ethanol. The filtrates were combined and the solvent was removed by evaporation to give 94.9 g of a highly moist orange solid. The solid was mixed with 400 mL of dichloromethane to dissolve the organic product. The turbid solution was filtered to remove inorganic salts. The filtrate was transferred to a partition funnel to separate the organic phase and remove the aqueous residue. The organic phase was dried over anhydrous sodium sulfate and evaporated to dryness to give 30.8 g of 3-chloro-4-(3-fluorobenzyloxy)aniline (Yield: 96%, Purity as determined by HPLC: 99.67%, Major impurity content: 0.10%).

References

[1] Patent: US2004/53946, 2004, A1
[2] Patent: US2015/366868, 2015, A1. Location in patent: Paragraph 0158
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 14, p. 5522 - 5537
[4] Patent: WO2009/33581, 2009, A1. Location in patent: Page/Page column 59-60
[5] Patent: WO2009/63054, 2009, A1. Location in patent: Page/Page column 68-69

3-Chloro-4-(3-fluorobenzyloxy)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Chloro-4-(3-fluorobenzyloxy)aniline Suppliers

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View Lastest Price from 3-Chloro-4-(3-fluorobenzyloxy)aniline manufacturers

Moxin Chemicals
Product
Lapatinib Impurity10 202197-26-0
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
99%+ HPLC
Supply Ability
1000
Release date
2025-06-27
WUHAN FORTUNA CHEMICAL CO., LTD
Product
3-Chloro-4-(3-fluorobenzyloxy)aniline 202197-26-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%min
Supply Ability
200kg
Release date
2021-08-25
Henan Aochuang Chemical Co.,Ltd.
Product
3-Chloro-4-(3-fluorobenzyloxy)aniline 202197-26-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30

202197-26-0, 3-Chloro-4-(3-fluorobenzyloxy)anilineRelated Search:

Acid Blue 93 alpha-Chloro-o-fluorotoluene Aniline 4-(Trifluoromethoxy)aniline 4-Methoxybenzylchloride 2-(Trifluoromethyl)benzyl chloride p-Anisidine o-Anisidine m-Anisidine (Trifluoromethoxy)benzene 5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde Lapatinib iMpurity Lapatinib Impurity 16 O-De(3-fluorobenzyl) Lapatinib Lapatinib impurity L Lapatinib 4-Fluoro Impurity N-De[2-(Methylsulfonyl)ethyl] Lapatinib Lapatinib IMpurity 8

  • 4-(3-Fluorobenzyloxy)-3-chlorobenzenamine
  • 3-Chloro-4-[(3-fluorophenyl)Methoxy]benzenaMine
  • 4-(3-Fluorobenzyloxy)- 3-chloroaniline
  • 3-Chloro-4-(3-fluorobenzyloxy)-anilin
  • 4-(3-Fluorobenzyloxy)-3-chlorobenzenamine hydrochloride
  • 3-chloro-4-[(3-fluorophenyl)Methoxy]aniline
  • BenzenaMine, 3-chloro-4-[(3-fluorophenyl)Methoxy]-
  • 3-Chloro-4-(3-Flurobenzyloxy) PhenylaMine (LTB-A)
  • 4 - (3-3 - chloro - fluorobenzene Methoxy) aniline
  • 3-Chloro-4-(3-fluorobenzyloxy)aniline 3-Chloro-4-(3-fluorobenzyloxy)phenylamine
  • Lapatinib genotoxic impurity 1
  • 3-Chloro-4-((3-fluorobenzyl)
  • 3-Chloro-4-(3-fluorobenzyloxy)-aniline
  • 3-Chloro-4-(3-fluorobenzyloxy)phenylamine
  • Lapatinib impurity A
  • Lapatinib Impurity 18-d4
  • Lapatinib impurity 4 3-Chloro-4-(3-fluorobenzyloxy)aniline
  • 3-Chloro-4-(3-fluorobenzyloxy)aniline&gt
  • 3-Chloro-4-(3-fluorobenzyloxy)aniline, 99%, for synthesis
  • oro-4-(3-fL
  • oxy)aniL
  • 3-Chloro-4-(3-fluorobenzyloxy)aniline ISO 9001：2015 REACH
  • 3-Chloro-4-((3-fluorobenzyl)oxy)aniline (Lapatinib Impurity)
  • Compound PDK0113
  • LAPATINIB IMP A
  • 202197-26-0
  • 20297-26-0
  • Lapatinib
  • API intermediates
  • 202197-26-0