METHYL ACETIMIDATE HYDROCHLORIDE
- Product Name
- METHYL ACETIMIDATE HYDROCHLORIDE
- CAS No.
- 14777-27-6
- Chemical Name
- METHYL ACETIMIDATE HYDROCHLORIDE
- Synonyms
- METHYL ACETIMIDATE HCL;AcetimidicacidmethylesterHCl;METHYL ACETIMIDATE HYDROCHLORIDE;METHYL ACETIMIDATE HYDROCHLORIDE, TECH.;acetimidicacid,methylester,hydrochloride;ethanimidicacid,methylester,hydrochloride;Methyl acetiMidate hydrochloride , Technical;Methyl acetimidate hydrochloride technical grade;Ethanimidic acid, methyl ester, hydrochloride (1:1);Methyl acetimidate hydrochlorideTechnical, ≥ 99% (Assay by Titration)
- CBNumber
- CB6146601
- Molecular Formula
- C3H8ClNO
- Formula Weight
- 109.55
- MOL File
- 14777-27-6.mol
METHYL ACETIMIDATE HYDROCHLORIDE Property
- Melting point:
- 105 °C (dec.)(lit.)
- storage temp.
- 2-8°C
- Appearance
- White to off-white Solid
- BRN
- 3671581
- EPA Substance Registry System
- Ethanimidic acid, methyl ester, hydrochloride (14777-27-6)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 254940
- Product name
- Methyl acetimidate hydrochloride
- Purity
- technical grade
- Packaging
- 25g
- Price
- $620
- Updated
- 2025/07/31
- Product number
- 254940
- Product name
- Methyl acetimidate hydrochloride
- Purity
- technical grade
- Packaging
- 100g
- Price
- $1610
- Updated
- 2023/01/07
- Product number
- M275025
- Product name
- Methyl acetimidate hydrochloride
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR953398
- Product name
- Methyl acetimidate hydrochloride
- Purity
- 90%
- Packaging
- 5g
- Price
- $131
- Updated
- 2021/12/16
- Product number
- DYE0000520
- Product name
- METHYL ACETIMIDATE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $490
- Updated
- 2021/12/16
METHYL ACETIMIDATE HYDROCHLORIDE Chemical Properties,Usage,Production
Chemical Properties
White to yellow powder
Uses
Methyl acetimidate hydrochloride has been used in pre-crystallization chemical modification of lysine residues.
General Description
Methyl acetimidate hydrochloride is an inhibitor of N-methylation of phosphatidylethanolamine. It also prevents the stimulation of purified cardiac sarcolemmal vesicles Ca2+-pump activities.
Synthesis
67-56-1
75-05-8
14777-27-6
1) Example 1-1: Preparation of methyl acetimidate hydrochloride 1.6 kg of acetonitrile and 2.4 kg of methanol were added to the reactor and the reaction system was cooled to -10 °C. 3.67 kg of acetyl chloride was slowly added dropwise with stirring, and the rate of dropwise acceleration was controlled to maintain the reaction temperature at 0 °C. After the dropwise addition, the reaction mixture was continued to be stirred at room temperature for 12 hours. After completion of the reaction, the volatile solvent was removed by distillation under reduced pressure at 45 °C. To the residue was added 11.8 kg of tert-butyl methyl ether and stirred at room temperature for 3 hours to promote crystallization. The precipitated solid product was collected by filtration and dried under vacuum at 40 °C to give 4.1 kg of methylglyoxylate hydrochloride (yield: 95%). The product was characterized by 1H-NMR (400 MHz, DMSO-d6): δ 11.7 (s, 2H), 4.07 (s, 3H), 2.38 (s, 3H).
Purification Methods
Crystallise the imidate from methanol by adding dry ether to a ratio of 1:1 and cooling at 0o. Filter off the crystals in a cold room, wash them with methanol/ether (1:2), then dry in a vacuum. [Hunter & Ludwig J Am Chem Soc 84 3491 1962.] The free base has b 90-91o/765mm, d 0.867, n 1.403. [Hunter & Ludwig Methods Enzymol 25 585 1973, Beilstein 2 IV 181.]
References
[1] Journal of Organic Chemistry, 1986, vol. 51, # 26, p. 5111 - 5123
[2] Patent: WO2015/5615, 2015, A1. Location in patent: Paragraph 138; 139; 140
[3] Chemische Berichte, 1985, vol. 118, # 8, p. 3089 - 3104
[4] Analytical Chemistry, 2006, vol. 78, # 18, p. 6398 - 6403
[5] Synlett, 2001, # 11, p. 1707 - 1710
METHYL ACETIMIDATE HYDROCHLORIDE Preparation Products And Raw materials
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View Lastest Price from METHYL ACETIMIDATE HYDROCHLORIDE manufacturers
- Product
- METHYL ACETIMIDATE HYDROCHLORIDE 14777-27-6
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 20kg/month
- Release date
- 2019-11-05