CORTICOTROPIN RELEASING FACTOR ANTAGONIST

CORTICOTROPIN RELEASING FACTOR ANTAGONIST Property

storage temp. 

Desiccate at -20°C

solubility 

Soluble to 1 mg/ml in 0.1% TFA

form 

Powder

color 

White to off-white

Hazard and Precautionary Statements (GHS)

CORTICOTROPIN RELEASING FACTOR ANTAGONIST Chemical Properties,Usage,Production

Uses

α-Helical CRF(9-41) is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) is also a partial agonist of CRF1 receptor with an EC50 of 140 nM[1][2].

References

[1] Sonia Tucci, et al. Corticotropin releasing factor antagonist, alpha-helical CRF(9-41), reverses nicotine-induced conditioned, but not unconditioned, anxiety. Psychopharmacology (Berl). 2003 May;167(3):251-6. DOI:10.1007/s00213-003-1403-4
[2] Smart D, et al. Characterisation using microphysiometry of CRF receptor pharmacology. Eur J Pharmacol. 1999 Aug 27;379(2-3):229-35. DOI:10.1016/s0014-2999(99)00506-3