ChemicalBook > CAS DataBase List > IEM 1460

IEM 1460

Product Name
IEM 1460
CAS No.
121034-89-7
Chemical Name
IEM 1460
Synonyms
IEM 1460;IEM-1460, GluR2 lacking AMPA receptor blocker;5-(1-adamantylmethylamino)pentyl-trimethylazanium:bromide:hydrobromide;N,N,H,-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromidehydrobromide;N,N,N-TRIMETHYL-5-[(TRICYCLO[3.3.1.13,7]DEC-1-YLMETHYL)AMINO]-1-PENTANAMINIUMBROMIDE HYDROBROMIDE
CBNumber
CB6148913
Molecular Formula
C19H38Br2N2
Formula Weight
454.34
MOL File
121034-89-7.mol
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IEM 1460 Property

storage temp. 
Desiccate at RT
solubility 
Soluble to 100 mM in water and to 100 mM in DMSO
form 
solid
color 
white
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15623
Product name
IEM 1460
Purity
≥98%
Packaging
10mg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
15623
Product name
IEM 1460
Purity
≥98%
Packaging
50mg
Price
$388
Updated
2024/03/01
Tocris
Product number
1636
Product name
IEM1460
Purity
≥98%(HPLC)
Packaging
50
Price
$526
Updated
2021/12/16
Tocris
Product number
1636
Product name
IEM1460
Purity
≥98%(HPLC)
Packaging
10
Price
$125
Updated
2021/12/16
TRC
Product number
I942010
Product name
IEM1460
Packaging
10mg
Price
$275
Updated
2021/12/16
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IEM 1460 Chemical Properties,Usage,Production

Description

IEM 1460 is an adamantine derivative that blocks both AMPA- and NMDA-type glutamate receptor (GluR) channels (IC50 = 10 μM-0.1 mM). It is selective for Ca2+-permeable GluR channels, which lack the GluR2 R subunit, and has been used to identify Ca2+-permeable glutamate receptors in the brain.

Uses

IEM 1460 is an Adamantane derivative and open-channel blocker of AMPA currents.

Biological Activity

Voltage-dependent open-channel blocker of AMPA receptors. Displays selectivity between subtypes, blocking GluR2 subunit-lacking (Ca 2+ -permeable) receptors more potently than GluR2-containing receptors (IC 50 values are 2.6 and 1102 μ M respectively). Also blocks NMDA receptor-mediated currents. Anticonvulsant in vivo .

storage

Room temperature (desiccate)

IEM 1460 Preparation Products And Raw materials

Raw materials

Preparation Products

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IEM 1460 Suppliers

CHINA 32 Germany 2 Switzerland 1 United Kingdom 1 United States 9 USA 1 Global 46
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52924
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Abcam
Tel
--
Fax
--
Email
us.orders@abcam.com
Country
United States
ProdList
6001
Advantage
50
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
ASDI Incorporated
Tel
--
Fax
--
Email
customerservice@asdi.net
Country
United States
ProdList
6922
Advantage
67

121034-89-7, IEM 1460Related Search:

IEM-1460 DIBROMIDE IEM 1460

  • IEM 1460
  • N,N,N-TRIMETHYL-5-[(TRICYCLO[3.3.1.13,7]DEC-1-YLMETHYL)AMINO]-1-PENTANAMINIUMBROMIDE HYDROBROMIDE
  • N,N,H,-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromidehydrobromide
  • 5-(1-adamantylmethylamino)pentyl-trimethylazanium:bromide:hydrobromide
  • IEM-1460, GluR2 lacking AMPA receptor blocker
  • 121034-89-7
  • C19H37N2BrHBr
  • Selective inhibitor of a subtype of AMPA receptors (Ca2+ permeable, lacking GluR2 subunits); tool for functionally discriminating between AMPA receptors of different subunit composition
  • Ligand-Gated Ion Channels
  • Ion Channels
  • Ionotropic Glutamate Receptor Modulators
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Glutamate receptor