ChemicalBook > CAS DataBase List > AZD 5438

AZD 5438

Product Name
AZD 5438
CAS No.
602306-29-6
Chemical Name
AZD 5438
Synonyms
AZD;CS-1903;AZD 5438;AZD5438, >=98%;AZD 5438; AZD5438;AZD 5438 USP/EP/BP;AZD5438 >=97% (HPLC);4-[2-Methyl-1-(1-Methylethyl)-1H-iMidazol-5-yl]-N-[4-(Methylsulfonyl)phenyl]-;4-[2-Methyl-1-isopropyl-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine;4-[2-Methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine
CBNumber
CB61512498
Molecular Formula
C18H21N5O2S
Formula Weight
371.46
MOL File
602306-29-6.mol
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AZD 5438 Property

Boiling point:
655.2±65.0 °C(Predicted)
Density 
1.31
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
insoluble in H2O; ≥18.55 mg/mL in DMSO; ≥42.1 mg/mL in EtOH
form 
solid
pka
4.08±0.50(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1855
Product name
AZD5438
Purity
≥97% (HPLC)
Packaging
5MG
Price
$105
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1855
Product name
AZD5438
Purity
≥97% (HPLC)
Packaging
25MG
Price
$424
Updated
2024/03/01
Cayman Chemical
Product number
21598
Product name
AZD 5438
Purity
≥98%
Packaging
5mg
Price
$89
Updated
2024/03/01
Cayman Chemical
Product number
21598
Product name
AZD 5438
Purity
≥98%
Packaging
10mg
Price
$168
Updated
2024/03/01
Cayman Chemical
Product number
21598
Product name
AZD 5438
Purity
≥98%
Packaging
25mg
Price
$374
Updated
2024/03/01
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AZD 5438 Chemical Properties,Usage,Production

Uses

AZD 5438 is a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, which leads to leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts.

Definition

ChEBI: 4-(2-methyl-3-propan-2-yl-4-imidazolyl)-N-(4-methylsulfonylphenyl)-2-pyrimidinamine is a sulfonamide.

Biological Activity

azd5438 is a potent small molecule inhibitor of cyclin-dependent kinase (cdk) 1, 2 and 9 with half maximal inhibitory concentration ic50 of 16 nmol/l, 6 nmol/l and 20 nmol/l respectively. azd5438 has also been found to potently inhibit the human cyclin e/cdk2 complex, the cyclin b1/cdk1 complex and the cyclin a/cdk2 complex with ic50 of 0.006 μm, 0.016 μm and 0.045 μm respectively. in previous studies, azd5438 has exhibited significant anti-proliferative activity in a few human tumor cell lines with ic50 ranging from 0.2 μmol/l to 1.7 μmol/l, in which the phosphorylation of a few proteins, including cdk substrates prb, nucleolin, protein phosphatase 1a and rna polymerase ii cooh-terminal domain, and cell cycling at g2-m, s and g1 phases were inhibited.

storage

Desiccate at RT

References

[1]camidge dr1, smethurst d, growcott j, barrass nc, foster jr, febbraro s, swaisland h, hughes a. a first-in-man phase i tolerability and pharmacokinetic study of the cyclin-dependent kinase-inhibitor azd5438 in healthy male volunteers. cancer chemother pharmacol. 2007 aug;60(3):391-8. epub 2006 nov 18.
[2]byth kf, thomas a, hughes g, forder c, mcgregor a, geh c, oakes s, green c, walker m, newcombe n, green s, growcott j, barker a, wilkinson rw. azd5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. mol cancer ther. 2009 jul;8(7):1856-66. doi: 10.1158/1535-7163.mct-08-0836. epub 2009 jun 9.

AZD 5438 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD 5438 Suppliers

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View Lastest Price from AZD 5438 manufacturers

Career Henan Chemical Co
Product
AZD 5438 602306-29-6
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2019-12-25

602306-29-6, AZD 5438Related Search:

P-MENTHANE 4-METHYL-2-PENTYNE Cumene Alisertib (MLN8237) BMS-265246 PD 0332991 HCl (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Flavopiridol (Alvocidib) HCl Olaparib 1-ISOPROPYL-2,5-DIMETHYLIMIDAZOLE AZD 5438

  • 2-Pyrimidinamine,4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-
  • AZD 5438
  • 4-[2-Methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine
  • AZD
  • 4-[2-Methyl-1-(1-Methylethyl)-1H-iMidazol-5-yl]-N-[4-(Methylsulfonyl)phenyl]-
  • 2-Pyrimidinamine,4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-(AZD 5438)
  • 4-[2-Methyl-1-isopropyl-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine
  • 4-[2-Methyl-1-isopropyl-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine AZD 5438
  • AZD 5438 4-[2-Methyl-1-isopropyl-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine
  • AZD5438, >=98%
  • CS-1903
  • AZD 5438; AZD5438
  • AZD5438 >=97% (HPLC)
  • AZD 5438 USP/EP/BP
  • 602306-29-6
  • C18H21N5O2S
  • Inhibitors
  • API intermediates
  • Potent inhibitor of cyclin-dependent kinase (cdk) 1, 2 and 9.