5-ACETALDEHYDEYL-4,6-DICHLOROPYRIMIDINE
- Product Name
- 5-ACETALDEHYDEYL-4,6-DICHLOROPYRIMIDINE
- CAS No.
- 16019-33-3
- Chemical Name
- 5-ACETALDEHYDEYL-4,6-DICHLOROPYRIMIDINE
- Synonyms
- 5-Acetaldehydehyl-4,6-dichloropyrimidine;2-(4,6-Dichloropyrimidin-5-yl)acetaldehyde;2-(4,6-Dichloropyrimidin-5-yl);4,6-Dichloropyrimidine-5-acetaldehyde;4,6-Dichloro-5-pyrimidineacetaldehyde;1H-Indene-1,3(2H)-dione,5,9-dichloro-;5-PyriMidineacetaldehyde, 4,6-dichloro-;5-ACETALDEHYDEYL-4,6-DICHLOROPYRIMIDINE;5-Acetaldehydeyl-4,6-dichloropyrimidene;(4,6-dichloro-5-pyriMidinyl)acetaldehyde
- CBNumber
- CB61519730
- Molecular Formula
- C6H4Cl2N2O
- Formula Weight
- 191.01
- MOL File
- 16019-33-3.mol
5-ACETALDEHYDEYL-4,6-DICHLOROPYRIMIDINE Property
- Melting point:
- 89-91 °C(Solv: dichloromethane (75-09-2); heptane (142-82-5))
- Boiling point:
- 312.7±37.0 °C(Predicted)
- Density
- 1.470±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- solid
- pka
- -4.49±0.26(Predicted)
- color
- Yellow to faint orange
- InChI
- InChI=1S/C6H4Cl2N2O/c7-5-4(1-2-11)6(8)10-3-9-5/h2-3H,1H2
- InChIKey
- QEBITPOSBYZLCY-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=C(CC=O)C(Cl)=N1
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- D435378
- Product name
- 2-(4,6-Dichloropyrimidin-5-yl)acetaldehyde
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- J56052
- Product name
- 2-(4,6-Dichloropyrimidin-5-yl)acetaldehyde
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- OR313012
- Product name
- 5-Acetaldehydeyl-4,6-dichloropyrimidine
- Purity
- tech
- Packaging
- 1g
- Price
- $44
- Updated
- 2021/12/16
- Product number
- FD140731
- Product name
- 2-(4,6-Dichloropyrimidin-5-yl)acetaldehyde
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 058641
- Product name
- 2-(4,6-Dichloropyrimidin-5-yl)acetaldehyde
- Purity
- >95%
- Packaging
- 1g
- Price
- $54
- Updated
- 2021/12/16
5-ACETALDEHYDEYL-4,6-DICHLOROPYRIMIDINE Chemical Properties,Usage,Production
Chemical Properties
Crystalline solid
Synthesis
16019-31-1
16019-33-3
The general procedure for the synthesis of 4,6-dichloropyrimidine-5-acetaldehyde from 5-allyl-4,6-dichloropyrimidine was as follows: in a 50 mL three-necked flask equipped with a magnetic stirrer, 20 mL of dichloromethane and 4,6-dichloro-5-allylpyrimidine (5.0 g, 0.026 mol) were added sequentially, followed by dimethyl sulfoxide (8 g, 0.104 mol) and triethylamine. After cooling the reaction mixture to -40°C, ozone (O3) was passed through until the reaction solution took on a blue color, at which point the ozone passage was stopped and switched to nitrogen (N2) protection for 30 minutes to completely remove ozone from the system. Next, thiourea (2.0 g, 0.026 mol) was added to the reaction system and the reaction mixture was allowed to warm up to room temperature naturally. The reaction system was tested using starch potassium iodide test paper to confirm that no peroxide was present (the paper did not turn blue). Finally, 60 mL of water was added to the reaction mixture and extracted twice with dichloromethane. The yield of this step was 88%.
References
[1] Patent: CN108409745, 2018, A. Location in patent: Paragraph 0038; 0040; 0043; 0046; 0048; 0049; 0052
[2] Patent: WO2010/9195, 2010, A1. Location in patent: Page/Page column 76-77
[3] Patent: WO2010/9207, 2010, A1. Location in patent: Page/Page column 45
[4] Patent: WO2010/9208, 2010, A1. Location in patent: Page/Page column 73-74
[5] Patent: WO2011/62885, 2011, A1. Location in patent: Page/Page column 34
5-ACETALDEHYDEYL-4,6-DICHLOROPYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-ACETALDEHYDEYL-4,6-DICHLOROPYRIMIDINE manufacturers
- Product
- 2-(4,6-Dichloropyrimidin-5-yl)acetaldehyde 16019-33-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15
- Product
- 5-ACETALDEHYDEYL-4,6-DICHLOROPYRIMIDINE 16019-33-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2018-08-12