4,6-dichloropyrimidine-5-carbonitrile
- Product Name
- 4,6-dichloropyrimidine-5-carbonitrile
- CAS No.
- 5305-45-3
- Chemical Name
- 4,6-dichloropyrimidine-5-carbonitrile
- Synonyms
- 4,6-Dichloro-5-cyanopyriM...;4,6-Dichloropyrimidin-5-carbonitrile;4,6-Dichloro-5-pyrimidinecarbonitrile;4,6-dichloropyrimidine-5-carbonitrile;5-PyriMidinecarbonitrile, 4,6-dichloro-;4,6-dichloropyrimidine-5-carbonitrile CAS;4-aMino-2,6-dichloropyriMidine-5-carbonitrile;4,6-Dichloropyrimidine-5-carbonitrile 4,6-Dichloro-5-cyanopyrimidine
- CBNumber
- CB81458174
- Molecular Formula
- C5HCl2N3
- Formula Weight
- 173.99
- MOL File
- 5305-45-3.mol
4,6-dichloropyrimidine-5-carbonitrile Property
- Melting point:
- 145 °C
- Boiling point:
- 335.2±37.0 °C(Predicted)
- Density
- 1.60
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -7.00±0.26(Predicted)
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C5HCl2N3/c6-4-3(1-8)5(7)10-2-9-4/h2H
- InChIKey
- IPEBKIMUIHKZJP-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=C(C#N)C(Cl)=N1
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D438318
- Product name
- 4,6-Dichloropyrimidine-5-carbonitrile
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR51918
- Product name
- 4,6-Dichloropyrimidine-5-carbonitrile
- Purity
- 97%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 3H37-5-36
- Product name
- 4,6-Dichloro-5-cyanopyrimidine
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
- Product number
- OR51918
- Product name
- 4,6-Dichloropyrimidine-5-carbonitrile
- Purity
- 97%
- Packaging
- 5g
- Price
- $31
- Updated
- 2021/12/16
- Product number
- 3H37-5-36
- Product name
- 4,6-Dichloro-5-cyanopyrimidine
- Packaging
- 5G
- Price
- $34
- Updated
- 2021/12/16
4,6-dichloropyrimidine-5-carbonitrile Chemical Properties,Usage,Production
Uses
4,6-dichloropyrimidine-5-carbonitrile can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
4,6-Dichloro-5-pyrimidinecarbaldehyde oxime (8 g) was dissolved in CHCl3 (40 mL) and treated with SOCl2 (6 mL) for 2 h at rt. The solvent was removed and the residue was dissolved in DCM (5 mL). The resulting solid was filtered and washed with DCM (5 mL). The filtrate was concentrated under reduced pressure and purified by silica gel column chromatography using DCM-hexane (3:1) to give 4,6-dichloro-5-pyrimidinecarbonitrile. White solid.
References
[1] Patent: WO2004/65380, 2004, A1. Location in patent: Page 151-152
[2] Organic and Biomolecular Chemistry, 2011, vol. 9, # 5, p. 1516 - 1522
[3] Patent: WO2010/151735, 2010, A2. Location in patent: Page/Page column 56-57
[4] Patent: US2011/152296, 2011, A1. Location in patent: Page/Page column 15
[5] Patent: US2011/245257, 2011, A1. Location in patent: Page/Page column 15
4,6-dichloropyrimidine-5-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4,6-dichloropyrimidine-5-carbonitrile manufacturers
- Product
- 4,6-dichloropyrimidine-5-carbonitrile 5305-45-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-26
- Product
- 4,6-dichloropyriMidine-5-carbonitrile 5305-45-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15
- Product
- 4,6-Dichloropyrimidine-5-carbonitrile 5305-45-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-09