2-Amino-5-methoxybenzoic acid

Product Name: 2-Amino-5-methoxybenzoic acid
CAS No.: 6705-03-9
Chemical Name: 2-Amino-5-methoxybenzoic acid
Synonyms: 5-METHOXYANTHRANILIC ACID;2-AMino-5-Methoxyben;2-Amino-5-Methoxybenzoic;Mefenamic Acid Impurity 21;5-Methoxyanththranillic Acid;Anthranilic acid, 5-methoxy-;2-AMINO-5-METHOXYBENZOIC ACID;2-AMINO-5-METHOXYLBENZOIC ACID;2-azanyl-5-methoxy-benzoic acid;2-Amino-5-MethoxybenzoicAcid98%
CBNumber: CB6161046
Molecular Formula: C8H9NO3
Formula Weight: 167.16
MOL File: 6705-03-9.mol

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2-Amino-5-methoxybenzoic acid Property

Melting point:: 148-152 °C
Boiling point:: 349.9±27.0 °C(Predicted)
Density: 1.303±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Methanol (Slightly)
form: Crystalline Powder
pka: 2.08±0.10(Predicted)
color: White to yellow to pale orange
BRN: 777690
InChI: InChI=1S/C8H9NO3/c1-12-5-2-3-7(9)6(4-5)8(10)11/h2-4H,9H2,1H3,(H,10,11)
InChIKey: UMKSAURFQFUULT-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC(OC)=CC=C1N
CAS DataBase Reference: 6705-03-9(CAS DataBase Reference)
NIST Chemistry Reference: 5-Methoxyanthranilic acid(6705-03-9)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38-20/21/22
Safety Statements: 26-36/37/39-36-37
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29225090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 665118
Product name: 2-Amino-5-methoxybenzoic acid
Purity: 97%
Packaging: 1g
Price: $86.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 665118
Product name: 2-Amino-5-methoxybenzoic acid
Purity: 97%
Packaging: 5g
Price: $128
Updated: 2025/07/31

TCI Chemical

Product number: A1767
Product name: 2-Amino-5-methoxybenzoic Acid
Packaging: 5G
Price: $90
Updated: 2025/07/31

TCI Chemical

Product number: A1767
Product name: 2-Amino-5-methoxybenzoic Acid
Packaging: 25G
Price: $267
Updated: 2025/07/31

TRC

Product number: A611915
Product name: 2-Amino-5-methoxybenzoic acid
Packaging: 10g
Price: $140
Updated: 2021/12/16

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2-Amino-5-methoxybenzoic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

2-Amino-5-methoxybenzoic acid is a general reagent used in the synthesis of substituted isoquinolinonaphthyridines, quinazolinones, imidazobenzodiazepines, pyridoquinazolones and polycyclic hexahydrobenzo[c]acridines.

Uses

2-Amino-5-methoxybenzoic Acid is used in the synthesis of quinazolinone class of histamine H3 receptor inverse agonists. It is also used in the synthesis of Alogliptin, a selective inhibitor of the s erine protease dipeptidyl peptidase IV.

Definition

ChEBI: 2-Amino-5-methoxybenzoic acid is a methoxybenzoic acid.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

1882-69-5

6705-03-9

Using 5-methoxy-2-nitrobenzoic acid (1) as starting material, its nitro group was reduced by catalytic hydrogenation using H2 and Pd/C to afford 2-amino-5-methoxybenzoic acid (2) in quantitative yield. Subsequently, compound (2) was subjected to diazotization reaction with NaNO2 followed by treatment with Na2S2 to obtain stable disulfide compound (3) in 80% yield. This disulfide (3) was directly reacted with SOCl2 without further purification, followed by reaction with 2-chloroethylamine in the presence of Et3N to produce amide (4) in 90% yield. The compound (4) was converted to the cyclized product (5) by a one-pot method with trimethylphosphine and Et3N co-refluxed in THF. Finally, reduction of the cyclized amide (5) using LiAlH4 afforded 7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine (6).

References

[1] Patent: US2007/49572, 2007, A1. Location in patent: Page/Page column 34
[2] Patent: US2005/215540, 2005, A1. Location in patent: Page/Page column 37
[3] Patent: WO2016/23826, 2016, A1. Location in patent: Page/Page column 40
[4] Synthesis (Germany), 2017, vol. 49, # 1, p. 135 - 144
[5] Medicinal Chemistry Research, 2002, vol. 11, # 9, p. 504 - 537

2-Amino-5-methoxybenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-5-methoxybenzoic acid Suppliers

Canada 1 China 265 Europe 3 Germany 2 India 11 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 2 United Kingdom 13 United States 33 Global 334

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View Lastest Price from 2-Amino-5-methoxybenzoic acid manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 2-Amino-5-methoxybenzoic acid 6705-03-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-08-22

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Amino-5-methoxybenzoic acid 6705-03-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-28

Career Henan Chemical Co

Product: 2-Amino-5-methoxybenzoic acid 6705-03-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-20

6705-03-9, 2-Amino-5-methoxybenzoic acid Related Search:

4-Aminobenzoic acid 3,4-Dimethoxybenzoic acid 2-Amino-5-methylbenzoic acid ALTRENOGEST (Trifluoromethoxy)benzene 2-BROMO-5-METHOXYBENZOIC ACID 2,6-Dimethoxybenzoic acid 4-Dimethylaminobenzoic acid Glycine Tris(hydroxymethyl)aminomethane D-ribo-Hexanoic acid, 3-deoxy-, γ-lactone Methyl 2-amino-3,4,5-trimethoxybenzoate Anthranilic acid ETHYL 4,5-DIMETHOXY-2-NITROBENZOATE 2-AMINO-3,4,5-TRIMETHOXYBENZOIC ACID Methyl 2-nitro-3,4,5-trimethoxybenzoate 2-Amino-4,5-dimethoxybenzoic acid Bifenox

5-METHOXYANTHRANILIC ACID

5-Methoxyanththranillic Acid

2-AMINO-5-METHOXYLBENZOIC ACID

2-Amino-5-MethoxybenzoicAcid98%

2-Amino-5-Methoxybenzoic

2-AMINO-5-METHOXYBENZOIC ACID

2-azanyl-5-methoxy-benzoic acid

2-AMino-5-Methoxyben

2-AMino-5-Methoxybenzoic acid 97%

2-AMino-5-Methoxybenzoic acid, 95+%

5-Methoxyanthranilic acid, 6-Amino-m-anisic acid

Anthranilic acid, 5-methoxy-

Benzoic acid, 2-amino-5-methoxy-

2-Amino-5-methoxybenzoic acid USP/EP/BP

2-Amino-5-dimethoxybenzoic acid

Mefenamic Acid Impurity 21

6705-03-9

6705-3-9

1755-05-9

705-03-9

1755059

67005-03-9

C8H6N03

H2NC6H3OCH3CO2H

Unnatural Amino Acid Derivatives

Peptide Synthesis

Specialty Synthesis

Aromatic Amino Acids

Organic acids

Carboxylic Acids

Phenyls & Phenyl-Het

Aromatic Amino Acids

Peptide Synthesis

Unnatural Amino Acid Derivatives

Thiophenes

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

Carboxylic Acids

Phenyls & Phenyl-Het

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