Chemical Properties Uses production method
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Salinomycin

Chemical Properties Uses production method
Product Name
Salinomycin
CAS No.
55721-31-8
Chemical Name
Salinomycin
Synonyms
Salinomycin;Salinomycin Na;Salinomycin-Natrium;Salomycin sodium salt;Glycerol Impurity 109;Salinomycin sodium premix;Salinomycin 1-sodium salt;Salinomycin, monosodium salt;C16904500 Salinomycin sodium;Salinomycin, sodiumsalt (1:1)
CBNumber
CB6161783
Molecular Formula
C42H71NaO12
Formula Weight
791
MOL File
55721-31-8.mol
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Salinomycin Property

Melting point:
140-142°
alpha 
D25 -37° (c = 1 in ethanol)
storage temp. 
APPROX 4°C
solubility 
Soluble in DMSO.
form 
Solid
color 
White
Merck 
13,8415
BRN 
4901827
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
2811
WGK Germany 
3
HazardClass 
6.1
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13579
Product name
Salinomycin (sodium salt)
Purity
≥90%
Packaging
5mg
Price
$13
Updated
2021/12/16
Cayman Chemical
Product number
13579
Product name
Salinomycin (sodium salt)
Purity
≥90%
Packaging
10mg
Price
$23
Updated
2021/12/16
Cayman Chemical
Product number
13579
Product name
Salinomycin (sodium salt)
Purity
≥90%
Packaging
50mg
Price
$78
Updated
2021/12/16
Cayman Chemical
Product number
13579
Product name
Salinomycin (sodium salt)
Purity
≥90%
Packaging
100mg
Price
$130
Updated
2021/12/16
TRC
Product number
S088800
Product name
SalinomycinSodiumSalt(12%min.)
Packaging
5mg
Price
$50
Updated
2021/12/16
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Salinomycin Chemical Properties,Usage,Production

Chemical Properties

White or light yellow crystalline powder, slight specific smell, melting point 140-142 ℃. Soluble in acetone, chloroform, benzene, ethyl acetate, diethyl ether and methanol, almost insoluble in water. Rats by oral LD5070-100mg/kg, mice orally LD5050mg/kg, chicken LD50150mg/kg.

Uses

Salinomycin is safe and effective coccidiostat,which has inhibitory effect on most Gram-positive bacteria ,it also has effect on chicken coccidiosis, soft Ehrlich, Ehrlich poison, giant Ehrlich, Ehrlich and heap-shaped ball Harrington insects. It can be used for chicken feed, the amount is 50-60g/t,it should be stopped during laying period, the period is 5 days. Equine animals are hanged, it causes death after use; and it is banned using it with tiamulin, oleandomycin simultaneously.
The above information is edited by the chemicalbook of Tian Ye.

production method

It is produced by fermentation of white Streptomyces (Streptomyces albus).

Description

Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma.1?Salinomycin Na displays selective toxicity for cancer stem cells.1?Induces rapid mitochondrial hyperpolarization.2?Induces selective cytotoxicity to MCF-7 mammosphere cells via the hedgehog signaling pathway.3?Salinomycin Na reduces doxorubicin resistance of breast tumor cells by inhibiting drug efflux pump expression and activity.4?Kills cancer stem cells by sequestering iron.5

Chemical Properties

Brown Solid

Uses

Salinomycin is an ionophore agent.

Uses

Salinomycin sodium is prepared from salinomycin taking advantage of the acidic carboxylic acid which ionises and readily forms the salt in sodium hydroxide solutions. The sodium salt is the preferred formulation in animals to prevent coccidiosis and to promote growth. Salinomycin has a high affinity for monovalent cations, particularly potassium. Recently, salinomycin has been shown to inhibit cancer stem cells.

References

1) Gupta?et al. (2009),?Identification of selective inhibitors of cancer stem cells by high-throughput screening; Cell,?138?645 2) Manago?et al. (2015),?Early effects of the antineoplastic agent salinomycin on mitochondrial function; Cell Death Dis.,?6?e1930 3) Fu?et al. (2016),?Salinomycin induces selective cytotoxicity to MCF-7 mammosphere cells through targeting the Hedgehog signaling pathway;?Oncol. Rep.,?35?912 4)?Kim?et al.?(2015), Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin;?Mol. Med. Rep.,?12(2)?1898 5) Mai et al. (2017)?Salinomycin kills cancer stem cells by sequestering iron in lysosomes; Nat. Chem.,?9?1025

Salinomycin Preparation Products And Raw materials

Raw materials

Ammonium L-tartrate

Preparation Products

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Salinomycin Suppliers

Canada 1 China 121 Germany 2 India 2 Japan 1 Switzerland 1 United Kingdom 2 United States 17 Global 147
BOC Sciences
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1-631-485-4226; 16314854226
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021-58955995
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+1-800-259-7612
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+1-708-310-1919 +1-13798911105
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Alfa Chemistry
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View Lastest Price from Salinomycin manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Salinomycin 55721-31-8
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-17
Hebei Weibang Biotechnology Co., Ltd
Product
Salinomycin 55721-31-8
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 mt
Release date
2024-11-13
Shandong Deshang Chemical Co., Ltd.
Product
Salinomycin 55721-31-8
Price
US $6.90-4.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 tons
Release date
2024-06-28

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