DEXBROMPHENIRAMINE
- Product Name
- DEXBROMPHENIRAMINE
- CAS No.
- 132-21-8
- Chemical Name
- DEXBROMPHENIRAMINE
- Synonyms
- Disomer;D-Brompheniramine;DEXBROMPHENIRAMINE;d-Parabromdylamine;(S)-Brompheniramine;DEXBROMPHENIRAMINE BASE;DEXBROMPHENIRAMINE USP/EP/BP;(S)-γ-(4-Bromophenyl)-N,N-dimethyl-2-pyridinepropan-1-amine;[(3S)-3-(4-bromophenyl)-3-(2-pyridyl)propyl]-dimethyl-amine;2-Pyridinepropanamine, γ-(4-bromophenyl)-N,N-dimethyl-, (γS)-
- CBNumber
- CB6164683
- Molecular Formula
- C16H19BrN2
- Formula Weight
- 319.24
- MOL File
- 132-21-8.mol
DEXBROMPHENIRAMINE Property
- alpha
- D25 +42.7° (c = 1 in DMF)
- pka
- pKa 9.3 (Uncertain)
N-Bromosuccinimide Price
- Product number
- API0002276
- Product name
- DEXBROMPHENIRAMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $345.4
- Updated
- 2021/12/16
DEXBROMPHENIRAMINE Chemical Properties,Usage,Production
Originator
Disomer,White,US,1959
Uses
Antihistaminic.
Definition
ChEBI: The (pharmacologically active) (S)-(+)-enantiomer of brompheniramine. A histamine H1 receptor antagonist, it is used (commonly as its maleate salt) for the symptomatic relief of allergic conditions, including rhinitis nd conjunctivitis.
Manufacturing Process
The following is taken from US Patent 3,061,517. Sixteen grams of racemic 3-
(2-pyridyl)-3-p-bromophenyl-N,N,-dimethylpropylamine and 9.7 grams of dphenylsuccinic acid are dissolved in 150 ml of absolute alcohol and kept at
room temperature until crystallization is effected. The crystals are filtered,washed with absolute ethyl alcohol, and recrystallized from the same solvent
using 5 ml there of per gram of solid. Three subsequent crystallizations from
80% alcohol give d-3-(2-pyridyl)-3-p-bromophenyl-N,N-dimethylpropylamined-phenylsuccinate; MP 152-154°C; [α]D25 91 (concentration, 1% in
dimethylformamide).
The free base, d-3-(2-pyridyl)-3-p-bromophenyl-N,N-dimethylpropylamine, is
obtained from this salt with diethyl ether and aqueous potassium carbonate;
[α]D25 +42.7 (concentration, 1% in dimethylformamide). The free base is then
reacted with maleic acid.
brand name
Disomer (Schering).
Therapeutic Function
Antihistaminic
DEXBROMPHENIRAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
DEXBROMPHENIRAMINE Suppliers
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- 010-56205725
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View Lastest Price from DEXBROMPHENIRAMINE manufacturers
- Product
- DEXBROMPHENIRAMINE 132-21-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-17