DEXBROMPHENIRAMINE MALEATE
- Product Name
- DEXBROMPHENIRAMINE MALEATE
- CAS No.
- 2391-03-9
- Chemical Name
- DEXBROMPHENIRAMINE MALEATE
- Synonyms
- D03704;Disophrol;Disomer (tn);disomermaleate;DexbroMpheniraMin;Brompheniramine d-;Dexbrompheniraminum;d-brompheniraminemaleate;DEXBROMPHENIRAMINE MALEATE;(S)-BroMpheniraMine Maleate
- CBNumber
- CB1675360
- Molecular Formula
- C20H23BrN2O4
- Formula Weight
- 435.31
- MOL File
- 2391-03-9.mol
DEXBROMPHENIRAMINE MALEATE Property
- Melting point:
- 132-134℃
- storage temp.
- -20°C Freezer
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
Safety
- Hazard Codes
- T
- Risk Statements
- 25
- Safety Statements
- 22-36/37/39-45
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- US4026200
- HS Code
- 2933399090
- Toxicity
- guinea pig,LD50,oral,259mg/kg (259mg/kg),SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYEBEHAVIORAL: TREMORBEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,Chemotherapia. Vol. 3, Pg. 120, 1961.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- FB19340
- Product name
- (S)-Brompheniramine maleate
- Packaging
- 10mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- FB19340
- Product name
- (S)-Brompheniramine maleate
- Packaging
- 25mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB19340
- Product name
- (S)-Brompheniramine maleate
- Packaging
- 50mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- FB19340
- Product name
- (S)-Brompheniramine maleate
- Packaging
- 100mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- FB19340
- Product name
- (S)-Brompheniramine maleate
- Packaging
- 250mg
- Price
- $300
- Updated
- 2021/12/16
DEXBROMPHENIRAMINE MALEATE Chemical Properties,Usage,Production
Originator
Disomer,White,US,1959
Uses
The S-enantimer of Brompheniramine maleate (B686355) as antihistaminic.
Definition
ChEBI: The maleic acid salt of the (pharmacologically active) (S)-(+)-enantiomer of brompheniramine. A histamine H1 receptor antagonist, it is used for the symptomatic relief of allergic conditions, including rhinitis and co junctivitis.
Manufacturing Process
The following is taken from US Patent 3,061,517. Sixteen grams of racemic 3-
(2-pyridyl)-3-p-bromophenyl-N,N,-dimethylpropylamine and 9.7 grams of dphenylsuccinic acid are dissolved in 150 ml of absolute alcohol and kept at
room temperature until crystallization is effected. The crystals are filtered,washed with absolute ethyl alcohol, and recrystallized from the same solvent
using 5 ml there of per gram of solid. Three subsequent crystallizations from
80% alcohol give d-3-(2-pyridyl)-3-p-bromophenyl-N,N-dimethylpropylamined-phenylsuccinate; MP 152-154°C; [α]D25 91 (concentration, 1% in
dimethylformamide).
The free base, d-3-(2-pyridyl)-3-p-bromophenyl-N,N-dimethylpropylamine, is
obtained from this salt with diethyl ether and aqueous potassium carbonate;
[α]D25 +42.7 (concentration, 1% in dimethylformamide). The free base is then
reacted with maleic acid.
brand name
Disomer (Schering).
Therapeutic Function
Antihistaminic
General Description
Like the chlorinederivative, the antihistaminic activity of brompheniramineexists predominantly in the dextro isomer, dexbrompheniraminemaleate (D-isomer), and is of comparable potency.
DEXBROMPHENIRAMINE MALEATE Preparation Products And Raw materials
Raw materials
Preparation Products
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