DEXBROMPHENIRAMINE MALEATE Property

Melting point:

132-134℃

storage temp. 

-20°C Freezer

solubility 

Methanol (Slightly), Water (Slightly)

form 

Solid

color 

White to Off-White

Safety

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

22-36/37/39-45

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

US4026200

HS Code 

2933399090

Toxicity

guinea pig,LD50,oral,259mg/kg (259mg/kg),SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYEBEHAVIORAL: TREMORBEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,Chemotherapia. Vol. 3, Pg. 120, 1961.

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

DEXBROMPHENIRAMINE MALEATE Chemical Properties,Usage,Production

Originator

Disomer,White,US,1959

Uses

The S-enantimer of Brompheniramine maleate (B686355) as antihistaminic.

Definition

ChEBI: The maleic acid salt of the (pharmacologically active) (S)-(+)-enantiomer of brompheniramine. A histamine H1 receptor antagonist, it is used for the symptomatic relief of allergic conditions, including rhinitis and co junctivitis.

Manufacturing Process

The following is taken from US Patent 3,061,517. Sixteen grams of racemic 3- (2-pyridyl)-3-p-bromophenyl-N,N,-dimethylpropylamine and 9.7 grams of dphenylsuccinic acid are dissolved in 150 ml of absolute alcohol and kept at room temperature until crystallization is effected. The crystals are filtered,washed with absolute ethyl alcohol, and recrystallized from the same solvent using 5 ml there of per gram of solid. Three subsequent crystallizations from 80% alcohol give d-3-(2-pyridyl)-3-p-bromophenyl-N,N-dimethylpropylamined-phenylsuccinate; MP 152-154°C; [α]D25 91 (concentration, 1% in dimethylformamide).
The free base, d-3-(2-pyridyl)-3-p-bromophenyl-N,N-dimethylpropylamine, is obtained from this salt with diethyl ether and aqueous potassium carbonate; [α]D25 +42.7 (concentration, 1% in dimethylformamide). The free base is then reacted with maleic acid.

brand name

Disomer (Schering).

Therapeutic Function

Antihistaminic

General Description

Like the chlorinederivative, the antihistaminic activity of brompheniramineexists predominantly in the dextro isomer, dexbrompheniraminemaleate (D-isomer), and is of comparable potency.