(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE

Product Name: (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
CAS No.: 39637-99-5
Chemical Name: (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
Synonyms: MOSHER'S ACID CHLORIDE;(-)-Mosher's Acid Chloride;(+)-MTPA-CL;(R)-(−(S)-(+)-MTPA-CL;(R)-MTPA chloride;(R)-(-)-Acid chloride;(+)-MOSHER'S CHLORIDE;(+)-MOSHER'S ACID CHLORIDE;(R)-(-)-Mosher'sacidchloride
CBNumber: CB6170769
Molecular Formula: C10H8ClF3O2
Formula Weight: 252.62
MOL File: 39637-99-5.mol

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(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Property

Boiling point:: 213-214 °C(lit.)
alpha: D25 -10.0± 0.1° (neat, l = 1)
Density: 1.35 g/mL at 25 °C(lit.)
refractive index: n20/D 1.469(lit.)
Flash point:: 194 °F
storage temp.: Inert atmosphere,Store in freezer, under -20°C
form: Liquid
Specific Gravity: 1.353
color: Clear colorless to light yellow
optical activity: [α]20/D 137±2°, c = 6.4% in carbon tetrachloride
Water Solubility: Sparingly miscible with water.
Sensitive: Moisture Sensitive
Merck: 14,6280
BRN: 3591565
CAS DataBase Reference: 39637-99-5(CAS DataBase Reference)

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-27-36/37/39-45
RIDADR: UN 3265 8/PG 2
WGK Germany: 3
F: 10-21
Hazard Note: Corrosive/Freeze
HazardClass: 8
PackingGroup: II
HS Code: 29189900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 65363
Product name: (R)-(?)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride
Purity: for chiral derivatization, ≥99.0%
Packaging: 100mg
Price: $147
Updated: 2024/03/01

Sigma-Aldrich

Product number: 65363
Product name: (R)-(?)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride
Purity: for chiral derivatization, ≥99.0%
Packaging: 500mg
Price: $578
Updated: 2024/03/01

TCI Chemical

Product number: M1104
Product name: (R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines]
Purity: >98.0%(GC)
Packaging: 100mg
Price: $55
Updated: 2024/03/01

TCI Chemical

Product number: M1104
Product name: (R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines]
Purity: >98.0%(GC)
Packaging: 1g
Price: $322
Updated: 2024/03/01

Alfa Aesar

Product number: L14325
Product name: (R)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, 98+%
Packaging: 50mg
Price: $54.9
Updated: 2024/03/01

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(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Chemical Properties,Usage,Production

Chemical Properties

clear colorless to light yellow liquid

Uses

(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride is used as a chiral acylating reagent, which is used in the resolution of amino acid enantiomers like 2,5-dimethoxy-4-methylamphetamine. It is also suitable for the determination of the optical composition of compounds extracted from biological fluids.

Purification Methods

The most likely impurity is the free acid due to hydrolysis and should be checked by IR. If free from acid, then distil, taking care to keep moisture out of the apparatus. Otherwise add SOCl2 and reflux for 5hours and distil it. Note that shorter reflux times result in a higher boiling fraction (b 130-155o/1mm) which has been identified as the anhydride. [Dale et al. J Org Chem 34 2543 1969, for enantiomeric purity see Dale & Mosher J Am Chem Soc 97 512 1973.]

(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Suppliers

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View Lastest Price from (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE manufacturers

Career Henan Chemical Co

Product: (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE 39637-99-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-09

39637-99-5, (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDERelated Search:

3,3,3-TRIFLUOROPROPIONYL CHLORIDE Phenylacetyl chloride (+/-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE,ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE 3-CHLORO-1,1,1-TRIFLUOROPROPANE (R)-1-Chloro-2-propanol 1-CHLORO-2-METHYL-2-PROPANOL Methoxyacetyl chloride 1-PHENYL-2,2,2-TRIFLUOROETHANOL 1-Pentanol (+/-)-2-CHLORO-1-PHENYLETHANOL (S)-1-Chloro-2-propanol 1-CHLORO-3-FLUOROISOPROPANOL (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE (+/-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID Acetyl chloride 3,3,3-Trifluoropropionic acid 2-PHENYL-1,1,1-TRIFLUOROPROPAN-2-OL

(R)-(fi)-alpha-methoxy-alpha-trifluoromethylphenylacetylchloride

(R)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, 98+%

(R)-(-)-MTPA-Cl, Moshers acid chloride

(S)-2-Methoxy-2-phenyl-3,3,3-trifluoropropionic acid chloride

(S)-2-Methoxy-3,3,3-trifluoro-2-phenylpropionic acid chloride

(S)-2-Phenyl-2-methoxy-3,3,3-trifluoropropionic acid chloride

[S,(+)]-α-Methoxy-α-(trifluoromethyl)benzeneacetic acid chloride

(R)-(-)-^a-Methoxy-^a-(trifluoromethyl)phenylacetyl chloride, 98+%

(R)-(-)-α-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride

(R)-(-)-α-Methoxy-α-(trifluoromethyl)benzeneacetylchloride (-)-MTPA-Cl

(R)-()-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride,(R)-()-MTPA-Cl, Mosher’s acid chloride

(1R)-(-)-1-Methoxy-1-(trifluoromethyl)phenylacetyl chloride 99% (99%ee)

(R)-(-)-alpha-Methoxy-alpha-trifluoromethylphenylacetyl chloride, 97+%

(2R)-(-)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoyl chloride 99% (99%ee)

(R)-(-)-MTPACl, (R)-(-)-Mosher's acid chloride, (2R)-(-)-2-Methoxy-2-phenyl-3,3,3-trifluoropropionyl chloride

(-)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetyl Chloride&nbsp

[for DeterMination of the optical purity of Alcohols and AMines]

(R)-2-Methoxy-2-(trifluoromethyl)phenylacetyl chloride

(2R)-(-)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoylchloride99%

(R)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride,99%

(2R)-(-)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoyl chloride 99%

(R)-(-)-alphaMethoxy-alpha(three fluoroMethyl)phenyl acetyl chloride

(R)-MTPA chloride

(2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl chloride

(R)-(-)-Acid chloride

(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl Chloride (ca. 18% in Dichloromethane, ca. 1.0mol/L) [for Determination of the optical purity of Alcohols and Amines]

(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines]

(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride, 99%, 18wt.% solution in dichloromethane

(R)-(-)-A-METHOXY-A-(TRIFLUOROMETHYL)-PH ENYLACETYL CHLORIDE, 98%(98% EE/GLC)

(R)-(-)-Mosher'sacidchloride

(R)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetylchloride(ee)

(-)--Methoxy--(trifluoromethyl)phenylacetylchloride

(r)-(-)-à-methoxy-à-(trifluoromethyl)phenylacetyl chloride

(R)-(-)-1-Methoxy-1-(trifluoromethyl)phenylacetyl chloride 99% (99%ee)

(r)-(-)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride (R)-(fi)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride (r)-(-)-a-methoxy-a-(trifluoromethyl) phenylacetyl chloride

(R)-(-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE 99%

(R)-(-)-1-Methoxy-1-(trifluoromethyl)phenylacetyl chloride (99%ee)

(R)-(-)-ɑ-Methoxy-ɑ-(trifluoromethyl)phenylacetyl chloride, 98+%

(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE

(+)-MTPA-CL

(+)-MOSHER'S ACID CHLORIDE

MOSHER'S ACID CHLORIDE

(+)-MOSHER'S CHLORIDE

(S)-(+)-A-METHOXY-A-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE

(S)-(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)BENZENEACETYLCHLORIDE

(S)-(-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE

(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE

(S)-(+)-MTPA-CL

(S)-(+)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYL ACETYL CHLORIDE

(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid chloride

(R)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl Chloride (ca. 18% in Dichloromethane, ca. 1.0mol/L)[for Determination of the optical purity of Alcohols and Amines]

(R)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines]

(-)-α-Methoxy-α-(trifluoromethyl)phenylacetylChloride[forDeterminationoftheopticalpurityofAlcoholsandAmines]&gt

(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride, 99%, n20D:1.4680 - 1.4700

Benzeneacetyl chloride, α-methoxy-α-(trifluoromethyl)-, (αR)-

(R)-(-)-a-Methoxy-a-trifluoromethylphenylacetyl chloride (ca. 18% in Dichloromethane, ca. 1.0mol/L)

(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride

(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl Chloride