FR 122047 HYDROCHLORIDE

Product Name: FR 122047 HYDROCHLORIDE
CAS No.: 130717-51-0
Chemical Name: FR 122047 HYDROCHLORIDE
Synonyms: FR 122047;FR122047HCl;FR 122047 HYDROCHLORIDE;COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem;5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine;5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole;(4,5-bis(4-methoxyphenyl)thiazol-2-yl)(4-methylpiperazin-1-yl)methanone HCl;[4,5-bis(4-methoxyphenyl)-2-thiazolyl]-(4-methyl-1-piperazin-4-iumyl)methanone;1-[(4,5-BIS(4-METHOXYPHENYL)-2-THIAZOYL)CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE;4,5-BIS(4-METHOXYPHENYL-2-[(1-METHYLPIPERAZIN-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE
CBNumber: CB6178619
Molecular Formula: C23H26ClN3O3S
Formula Weight: 459.99
MOL File: 130717-51-0.mol

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FR 122047 HYDROCHLORIDE Property

storage temp.: 2-8°C
solubility: methylene chloride: 50 mg/mL, slightly hazy, yellow
form: powder
color: faint yellow
biological source: synthetic (organic)
Water Solubility: Soluble to 10 mM in water

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: F7553
Product name: FR 122047 hydrochloride
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $712
Updated: 2025/07/31

Sigma-Aldrich

Product number: 236005
Product name: COX-1 Inhibitor, FR122047
Packaging: 5mg
Price: $226
Updated: 2025/07/31

Cayman Chemical

Product number: 10039
Product name: FR122047 (hydrochloride)
Packaging: 5mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 10039
Product name: FR122047 (hydrochloride)
Packaging: 50mg
Price: $606
Updated: 2024/03/01

Cayman Chemical

Product number: 10039
Product name: FR122047 (hydrochloride)
Packaging: 1mg
Price: $32
Updated: 2024/03/01

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FR 122047 HYDROCHLORIDE Chemical Properties,Usage,Production

Description

FR122047 is a selective inhibitor of COX-1. The IC₅₀ values for inhibition of human COX-1 and COX-2 are 0.028 and 65 μM, respectively. In human platelet-rich plasma, FR122047 inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation with an IC₅₀ of 180-200 nM, which is nearly 100 times more potent than aspirin. Unlike aspirin, FR122047 does not induce gastric damage upon oral administration at doses (100 mg/kg) far in excess of the dose needed for complete suppression of platelet COX-1. In some models of inflammation, such as collagen-induced arthritis in the rat, FR122047 has an anti-inflammatory effect, implying a role for COX-1 in these models.

Uses

FR 122047 Hydrochloride is a selective cyclooxygenase-1 (Cox-1) inhibitor.

Biological Activity

Selective cyclooxygenase-1 (COX-1) inhibitor (IC 50 values are 0.028 and 65 μ M for COX-1 and COX-2 respectively). Antiplatelet, analgesic and anti-inflammatory following oral administration in vivo .

IC 50

COX-1: 28 nM (IC₅₀)

storage

Desiccate at +4°C

References

[1] TAKEHIRO OCHI Toshio G Yukio Motoyama. The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor, in chemical nociceptive models[J]. European journal of pharmacology, 2000, 391 1: Pages 49-54. DOI: 10.1016/s0014-2999(00)00051-0
[2] MIWAKO DOHI . The anti-platelet actions of FR122047, a novel cyclooxygenase inhibitor[J]. European journal of pharmacology, 1993, 243 2: Pages 179-184. DOI: 10.1016/0014-2999(93)90378-u
[3] TAKEHIRO OCHI Toshio G. Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat chronic models of arthritis[J]. British Journal of Pharmacology, 2009, 135 3: 782-788. DOI: 10.1038/sj.bjp.0704511
[4] ANNA-KARIN JOHNSSON . COX-1 dependent biosynthesis of 15-hydroxyeicosatetraenoic acid in human mast cells[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2021, 1866 5: Article 158886. DOI: 10.1016/j.bbalip.2021.158886

FR 122047 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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FR 122047 HYDROCHLORIDE Suppliers

China 29 Germany 2 India 1 Switzerland 1 United Kingdom 4 United States 9 Global 46

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130717-51-0, FR 122047 HYDROCHLORIDERelated Search:

4,5-DIPHENYL-2-METHYLTHIAZOLE 4-(4-METHOXY-PHENYL)-2-METHYL-THIAZOLE 4-PHENYL-THIAZOLE-2-CARBALDEHYDE (4-METHYL-1,3-THIAZOL-2-YL)METHYLAMINE FR 122047 HYDROCHLORIDE N-Methylthiazole-2-methanamine C-(4-PHENYL-THIAZOL-2-YL)-METHYLAMINE 5-Methyl-1,3-thiazole-2-carboxaldehyde 1,3-Thiazole-2-carbaldehyde 1-THIAZOL-2-YLMETHYL-PIPERAZINE 4-METHYL-2-THIAZOLECARBOXALDEHYDE 97 1,3-Thiazole-2-carboxamide 2-AMINOMETHYLTHIAZOLE HYDROCHLORIDE 1-[[4,5-BIS(4-METHOXYPHENYL)-2-THIAZOLYL]CARBONYL]-4-METHYL-PIPERAZINE, MONOHYDROCHLORIDE HYDRATE

4,5-BIS(4-METHOXYPHENYL-2-[(1-METHYLPIPERAZIN-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE

4,5-BIS(4-METHOXYPHENYL)-2-[(1-METHYLPIPERAZINE-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE

1-[[4,5-BIS(4-METHOXYPHENYL)-2-THIAZOLYL]CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE

1-[(4,5-BIS(4-METHOXYPHENYL)-2-THIAZOYL)CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE

FR 122047

FR 122047 HYDROCHLORIDE

FR122047HCl

(4,5-Bis(4-Methoxyphenyl)thiazol-2-yl)(4-Methylpiperazin-1-yl)Methanone hydrochloride

COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem

[4,5-bis(4-methoxyphenyl)-2-thiazolyl]-(4-methyl-1-piperazin-4-iumyl)methanone

(4,5-bis(4-methoxyphenyl)thiazol-2-yl)(4-methylpiperazin-1-yl)methanone HCl

Methanone, [4,5-bis(4-methoxyphenyl)-2-thiazolyl](4-methyl-1-piperazinyl)-, hydrochloride (1:1)

5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole

5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine

FR 122047 hydrochloride,Cyclooxygenase,FR 122047,FR122047,inhibit,Inhibitor,COX,FR-122047

4,5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole, Hydrochloride|||1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride

130717-51-0

C23H25N3O3SHCl

A to C

Biochemicals and Reagents

BioChemical

Cyclooxygenase

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors

Enzyme Inhibitors by Enzyme

Prostanoid receptor and related