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FR 122047 HYDROCHLORIDE

Product Name
FR 122047 HYDROCHLORIDE
CAS No.
130717-51-0
Chemical Name
FR 122047 HYDROCHLORIDE
Synonyms
FR 122047;FR122047HCl;FR 122047 HYDROCHLORIDE;COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem;5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine;5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole;(4,5-bis(4-methoxyphenyl)thiazol-2-yl)(4-methylpiperazin-1-yl)methanone HCl;[4,5-bis(4-methoxyphenyl)-2-thiazolyl]-(4-methyl-1-piperazin-4-iumyl)methanone;1-[(4,5-BIS(4-METHOXYPHENYL)-2-THIAZOYL)CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE;4,5-BIS(4-METHOXYPHENYL-2-[(1-METHYLPIPERAZIN-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE
CBNumber
CB6178619
Molecular Formula
C23H26ClN3O3S
Formula Weight
459.99
MOL File
130717-51-0.mol
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FR 122047 HYDROCHLORIDE Property

storage temp. 
2-8°C
solubility 
methylene chloride: 50 mg/mL, slightly hazy, yellow
form 
powder
color 
faint yellow
Water Solubility 
Soluble to 10 mM in water
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F7553
Product name
FR 122047 hydrochloride
Purity
≥98% (HPLC), powder
Packaging
25mg
Price
$693
Updated
2024/03/01
Sigma-Aldrich
Product number
236005
Product name
COX-1 Inhibitor, FR122047
Packaging
5mg
Price
$259
Updated
2024/03/01
Cayman Chemical
Product number
10039
Product name
FR122047 (hydrochloride)
Packaging
5mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
10039
Product name
FR122047 (hydrochloride)
Packaging
50mg
Price
$606
Updated
2024/03/01
Cayman Chemical
Product number
10039
Product name
FR122047 (hydrochloride)
Packaging
1mg
Price
$32
Updated
2024/03/01
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FR 122047 HYDROCHLORIDE Chemical Properties,Usage,Production

Description

FR122047 is a selective inhibitor of COX-1. The IC50 values for inhibition of human COX-1 and COX-2 are 0.028 and 65 μM, respectively. In human platelet-rich plasma, FR122047 inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation with an IC50 of 180-200 nM, which is nearly 100 times more potent than aspirin. Unlike aspirin, FR122047 does not induce gastric damage upon oral administration at doses (100 mg/kg) far in excess of the dose needed for complete suppression of platelet COX-1. In some models of inflammation, such as collagen-induced arthritis in the rat, FR122047 has an anti-inflammatory effect, implying a role for COX-1 in these models.

Uses

FR 122047 Hydrochloride is a selective cyclooxygenase-1 (Cox-1) inhibitor.

Biological Activity

Selective cyclooxygenase-1 (COX-1) inhibitor (IC 50 values are 0.028 and 65 μ M for COX-1 and COX-2 respectively). Antiplatelet, analgesic and anti-inflammatory following oral administration in vivo .

storage

Desiccate at +4°C

FR 122047 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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FR 122047 HYDROCHLORIDE Suppliers

TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52924
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58
ApexBio Technology
Tel
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Fax
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Email
sales@apexbt.com
Country
United States
ProdList
6251
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58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
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Email
chemicals@usbio.net
Country
United States
ProdList
6214
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Riedel-de Haen AG
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Fax
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Country
United States
ProdList
6773
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3B Scientific Corporation
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Email
sales@3bsc.com
Country
United States
ProdList
6718
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EMD Biosciences, Inc.
Tel
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Fax
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Email
technical@calbiochem.com
Country
United States
ProdList
6529
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130717-51-0, FR 122047 HYDROCHLORIDERelated Search:


  • 4,5-BIS(4-METHOXYPHENYL-2-[(1-METHYLPIPERAZIN-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE
  • 4,5-BIS(4-METHOXYPHENYL)-2-[(1-METHYLPIPERAZINE-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE
  • 1-[[4,5-BIS(4-METHOXYPHENYL)-2-THIAZOLYL]CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE
  • 1-[(4,5-BIS(4-METHOXYPHENYL)-2-THIAZOYL)CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE
  • FR 122047
  • FR 122047 HYDROCHLORIDE
  • FR122047HCl
  • (4,5-Bis(4-Methoxyphenyl)thiazol-2-yl)(4-Methylpiperazin-1-yl)Methanone hydrochloride
  • COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem
  • [4,5-bis(4-methoxyphenyl)-2-thiazolyl]-(4-methyl-1-piperazin-4-iumyl)methanone
  • (4,5-bis(4-methoxyphenyl)thiazol-2-yl)(4-methylpiperazin-1-yl)methanone HCl
  • Methanone, [4,5-bis(4-methoxyphenyl)-2-thiazolyl](4-methyl-1-piperazinyl)-, hydrochloride (1:1)
  • 5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole
  • 5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine
  • FR 122047 hydrochloride,Cyclooxygenase,FR 122047,FR122047,inhibit,Inhibitor,COX,FR-122047
  • 4,5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole, Hydrochloride|||1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride
  • 130717-51-0
  • C23H25N3O3SHCl
  • A to C
  • Biochemicals and Reagents
  • BioChemical
  • Cyclooxygenase
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme
  • Prostanoid receptor and related