ChemicalBook > CAS DataBase List > 2-Chloroquinoxaline

2-Chloroquinoxaline

Product Name
2-Chloroquinoxaline
CAS No.
1448-87-9
Chemical Name
2-Chloroquinoxaline
Synonyms
Chloroquinoxaline;2-CHLOROQUINOXALINE;Quinoxaline, 2-chloro-;2-Chloroquinoxaline 98%;2-Chloroquinoxaline ,99%;2-Chloroquinoxaline, 97%+
CBNumber
CB6182221
Molecular Formula
C8H5ClN2
Formula Weight
164.59
MOL File
1448-87-9.mol
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2-Chloroquinoxaline Property

Melting point:
47-50 °C (lit.)
Boiling point:
100 °C/1.4 mmHg (lit.)
Density 
1.2847 (rough estimate)
refractive index 
1.5500 (estimate)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Toluene
form 
Crystalline Powder
pka
-1.21±0.30(Predicted)
color 
White to gray
InChI
InChI=1S/C8H5ClN2/c9-8-5-10-6-3-1-2-4-7(6)11-8/h1-5H
InChIKey
BYHVGQHIAFURIL-UHFFFAOYSA-N
SMILES
N1C2C(=CC=CC=2)N=CC=1Cl
CAS DataBase Reference
1448-87-9(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xn
Risk Statements 
25-36/37/38-22
Safety Statements 
26-36/37/39-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
136301
Product name
2-Chloroquinoxaline
Purity
98%
Packaging
1g
Price
$14.4
Updated
2025/07/31
Sigma-Aldrich
Product number
136301
Product name
2-Chloroquinoxaline
Purity
98%
Packaging
5g
Price
$83.5
Updated
2025/07/31
TCI Chemical
Product number
C3492
Product name
2-Chloroquinoxaline
Packaging
1G
Price
$52
Updated
2025/07/31
TCI Chemical
Product number
C3492
Product name
2-Chloroquinoxaline
Packaging
5G
Price
$158
Updated
2025/07/31
TRC
Product number
C381450
Product name
2-Chloroquinoxaline
Packaging
5g
Price
$90
Updated
2021/12/16
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2-Chloroquinoxaline Chemical Properties,Usage,Production

Chemical Properties

White to grey to purple or light brown powder

Uses

2-Chloroquinoxaline (QCI) was used to study the effect of solvent on hydrolysis of QCI in aqueous–organic solvent mixtures with acetonitrile and dimethylesulphoxide. It was used in the synthesis of 2-(3-butynyl-2-methyl-2-ol) quinoxaline.It was used as reagent in the synthesis of chloroquinoxaline sulfamide.

Synthesis

1196-57-2

1448-87-9

The general procedure for the synthesis of 2-chloroquinoxaline from 2-hydroxyquinoxaline is as follows: 2-chloroquinoxaline (1D-008) was efficiently prepared by dissolving 2-hydroxyquinoxaline in pure phosphorus oxychloride (POCl3, 2.3 equiv.) and reacting the reaction under reflux conditions for 1 hour. The reaction has been validated on a 100 g scale, typically yielding 103-105 g of product (98-99% yield). Rapid filtration of the crude reaction mixture through a silica gel pad yields a high purity product (99% purity by LCMS analysis). This reaction has been successfully scaled up to 600 g scale.

References

[1] Patent: US2017/143706, 2017, A1. Location in patent: Paragraph 0050; 0106; 0107
[2] Helvetica Chimica Acta, 2001, vol. 84, # 5, p. 1112 - 1118
[3] Heterocycles, 2005, vol. 65, # 1, p. 181 - 185
[4] Heterocycles, 2006, vol. 68, # 9, p. 1973 - 1979
[5] Journal of the Chemical Society, 1945, p. 622,625

2-Chloroquinoxaline Preparation Products And Raw materials

Raw materials

Ethanol N,N-Dimethylformamide Ethyl glyoxalate Toluene Phosphorus oxitrichloride N,N-Dimethylaniline Ethyl acetate PETROLEUM ETHER o-Phenylenediamine

Preparation Products

Sulfaquinoxaline
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View Lastest Price from 2-Chloroquinoxaline manufacturers

Shanghai Rlavie Technology Co ltd
Product
2-Chloroquinoxaline;Chloroquinoxaline 1448-87-9
Price
US $0.00-0.00/kg
Min. Order
0.001kg
Purity
98%minHPLC
Supply Ability
100kgs/month
Release date
2022-06-17
Honest Joy Holdings Limited
Product
2-Chloroquinoxaline 1448-87-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98.5%
Supply Ability
100 tons
Release date
2022-01-14
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Chloroquinoxaline 1448-87-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

1448-87-9, 2-ChloroquinoxalineRelated Search:

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