Pritumumab
- Product Name
- Pritumumab
- CAS No.
- 499212-74-7
- Chemical Name
- Pritumumab
- Synonyms
- pritumumab;Research Grade Pritumumab;Research Grade Pritumumab(DHC35301)
- CBNumber
- CB61856066
- Formula Weight
- 0
- MOL File
- Mol file
Pritumumab Property
- form
- Liquid
- color
- Colorless to light yellow
Pritumumab Chemical Properties,Usage,Production
Uses
Pritumumab is a natural human IgG1kappa mAb originally isolated from a regional draining lymph node of a patient with cervical carcinoma. Pritumumab recognizes vimentin expressing on the cell surface of the malignant tumor. Pritumumab can be used for glioblastoma research[1][2].
in vivo
Pritumumab is effective in preventing tumor growth in nude mice but not in SCID mice[1].
Pritumumab can limit the growth of xenograft glioma tumors in vivo only in the presence of intact cell-mediated immunity[1].
References
[1] Santosh Kesari, et al. Pritumumab binding to glioma cells induces ADCC and inhibits tumor growth. ASCO Annual Meeting I. 2017.
[2] Hugwil AV. The meaning of the anti-cancer antibody CLN-IgG (Pritumumab) generated by human × human hybridoma technology against the cyto-skeletal protein, vimentin, in the course of the treatment of malignancy. Med Hypotheses. 2013 Sep;81(3):489-95. DOI:10.1016/j.mehy.2013.05.037
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