ChemicalBook > CAS DataBase List > 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine

4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine

Product Name
4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine
CAS No.
876343-10-1
Chemical Name
4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine
Synonyms
4-chloro-6-iodo-7H-pyrrolo[2;4-Chloro-6-iodo-7H-pyrrol...;4-chloro-6-iodo-1H-pyrrolo[2,3-d]pyrimidine;4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine;7H-Pyrrolo[2,3-d]pyrimidine, 4-chloro-6-iodo-;4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine ISO 9001：2015 REACH;Product English Name: 4-Chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine
CBNumber
CB61856132
Molecular Formula
C6H3ClIN3
Formula Weight
279.47
MOL File
876343-10-1.mol
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4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine Property

Density 
2.284±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
9.74±0.50(Predicted)
Appearance
Light yellow to yellow Solid
InChI
InChI=1S/C6H3ClIN3/c7-5-3-1-4(8)11-6(3)10-2-9-5/h1-2H,(H,9,10,11)
InChIKey
DXPVKZYVQANEDW-UHFFFAOYSA-N
SMILES
C1=NC(Cl)=C2C=C(I)NC2=N1
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C381673
Product name
4-Chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine
Packaging
500mg
Price
$90
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-M-06
Product name
4-Chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine
Packaging
1g
Price
$225
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC138879
Product name
4-Chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine
Packaging
1g
Price
$130
Updated
2021/12/16
Ark Pharm
Product number
AK-27595
Product name
4-Chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine
Purity
97%
Packaging
1g
Price
$162
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC138879
Product name
4-Chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine
Packaging
2g
Price
$200
Updated
2021/12/16
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4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties,Usage,Production

Synthesis

186519-89-1

876343-10-1

The general procedure for the synthesis of 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidines from 4-chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidines was carried out as follows: according to the literature [20], 4-chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidines (1) (5.42 g, 18.5 mmol) were subjected to iodination reaction. Upon completion of the reaction, a 9:1 mixture of 2:3 (6.0 g) was obtained. The mixture was mixed with THF (125 mL) and a methanolic solution of 5 M NaOH (21 mL). After stirring for 2 hours at room temperature, saturated aqueous NH4Cl solution (125 mL) was added and the mixture was concentrated. The precipitate formed was collected by filtration and washed with water. Subsequently, the precipitate was ground with boiling acetonitrile (1 g/10 mL) to give 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine (3.96 g, 14.2 mmol, 77% yield) as a white solid with a melting point of 219 °C (decomposition) (220 °C reported in literature [20]).1H NMR (400 MHz, DMSO-d6) δ: 12.57 (s, 1H), 8.51 (s, 1H), 6.88 (s, 1H). The obtained 1H NMR data were in agreement with those reported in the literature [20].

References

[1] European Journal of Medicinal Chemistry, 2016, vol. 124, p. 583 - 607
[2] European Journal of Pharmaceutical Sciences, 2014, vol. 59, # 1, p. 69 - 82
[3] Patent: WO2015/959, 2015, A1

4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine manufacturers

Shanghai Rlavie Technology Co ltd
Product
4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine 876343-10-1
Price
US $0.00/KG
Min. Order
0.001KG
Purity
98%min
Supply Ability
100kgs/month
Release date
2022-05-10
Dideu Industries Group Limited
Product
4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine 876343-10-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-06
Career Henan Chemical Co
Product
4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine 876343-10-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98%-99.9%
Supply Ability
100kg
Release date
2020-01-10

876343-10-1, 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidineRelated Search:

4-CHLORO-6-METHYLTHIOPYRIMIDINE 4-CHLORO-6-CYANOQUINOLINE 4-CHLORO-6-METHOXY-QUINOLINE-3-CARBONITRILE 4-Chloro-6-hydrazinopyrimidine 4-Chloro-6-methylquinoline ETHYL 4-CHLORO-6-METHYL-3-QUINOLINECARBOXYLATE 4-chloro-6-methylquinoline-3-carbonitrile ethyl 4-chloro-6-methoxy-quinoline-3-carboxylate 4-chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine 4-chloro-6,7-dimethoxy-2-methylquinazoline 4-chloro-6-methoxy-2-methylpyrimidin-5-amine 2-AMINO-4-CHLORO-6-ETHOXYPYRIMIDINE 4-CHLORO-6,7-DIMETHYLENEDIOXYQUINAZOLINE (6-Chloro-pyrimidin-4-yl)-dimethyl-amine 4-CHLORO-6-NITROQUINAZOLINE ETHYL 4-CHLORO-6-FLUORO-3-QUINOLINECARBOXYLATE 4-CHLORO-6-FLUOROQUINAZOLINE 4-CHLORO-6-(METHYLTHIO)-1H-PYRAZOLO[3,4-D]PYRIMIDINE

  • 4-Chloro-6-iodo-7H-pyrrol...
  • 4-chloro-6-iodo-7H-pyrrolo[2
  • 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine
  • Product English Name: 4-Chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine
  • 4-chloro-6-iodo-1H-pyrrolo[2,3-d]pyrimidine
  • 7H-Pyrrolo[2,3-d]pyrimidine, 4-chloro-6-iodo-
  • 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine ISO 9001：2015 REACH
  • 876343-10-1
  • CHIRAL CHEMICALS
  • pyrimidine
  • Heterocycle-Pyrimidine series