1-(2,2,2-Trifluoroethyl)piperazine dihydrochloride
Uses- Product Name
- 1-(2,2,2-Trifluoroethyl)piperazine dihydrochloride
- CAS No.
- 13349-91-2
- Chemical Name
- 1-(2,2,2-Trifluoroethyl)piperazine dihydrochloride
- Synonyms
- 1-(2,2,2-TRIFLUOROETHYL)PIPERAZINE 2HCL;1-(2,2,2-Trifluoroethyl)piperazine dihydrochloride;Piperazine,1-(2,2,2-trifluoroethyl)-, dihydrochloride;1-(2,2,2-Trifluoroethyl)piperazine dihydrochloride ISO 9001：2015 REACH
- CBNumber
- CB61856369
- Molecular Formula
- C6H13F3N2Cl2
- Formula Weight
- 241.08
- MOL File
- 13349-91-2.mol
1-(2,2,2-Trifluoroethyl)piperazine dihydrochloride Property
- Melting point:
- 198-205 °C
- storage temp.
- Inert atmosphere,Room Temperature
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T897630
- Product name
- 1-(2,2,2-Trifluoroethyl)piperazinedihydrochloride
- Packaging
- 500mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 6093AA
- Product name
- 1-(2,2,2-Trifluoroethyl)piperazinedihydrochloride
- Packaging
- 100mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 098192
- Product name
- 1-(2,2,2-Trifluoroethyl)piperazine dihydrochloride
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $227
- Updated
- 2021/12/16
- Product number
- HCH0354693
- Product name
- 1-(2,2,2-TRIFLUOROETHYL)PIPERAZINE DIHYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.77
- Updated
- 2021/12/16
- Product number
- 098192
- Product name
- 1-(2,2,2-Trifluoroethyl)piperazine dihydrochloride
- Purity
- 95+%
- Packaging
- 1g
- Price
- $504
- Updated
- 2021/12/16
1-(2,2,2-Trifluoroethyl)piperazine dihydrochloride Chemical Properties,Usage,Production
Uses
1-(2,2,2-trifluoroethyl)piperazine dihydrochloride is a heterocyclic compound and can be used as a pharmaceutical synthesis intermediate.
Synthesis
692058-21-2
13349-91-2
The general procedure for the synthesis of 1-(2,2,2-trifluoroethyl)piperazine dihydrochloride from 1-Boc-4-(2,2,2-trifluoroethyl)piperazine was as follows: tert-butyl 4-(2,2,2-trifluoroethyl)piperazine-1-carboxylate (253 mg, 0.94 mmol) was dissolved in a dioxane solution (4.72 mL, 0.94 mmol) of methylene chloride (9 mL) and 4M hydrochloric acid. 18.9 mmol). The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the mixture was concentrated under vacuum and co-evaporated three times with dichloromethane to afford 1-(2,2,2-trifluoroethyl)piperazine dihydrochloride (200 mg, 0.977 mmol, 100% yield) as a beige solid.
References
[1] Patent: WO2018/102453, 2018, A1. Location in patent: Paragraph 237
[2] Patent: WO2004/41829, 2004, A1. Location in patent: Page 75
[3] Patent: WO2006/46031, 2006, A1. Location in patent: Page/Page column 46-47
1-(2,2,2-Trifluoroethyl)piperazine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(2,2,2-Trifluoroethyl)piperazine dihydrochloride manufacturers
- Product
- 1-(2,2,2-Trifluoroethyl)piperazine dihydrochloride 13349-91-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons
- Release date
- 2022-02-24
- Product
- 1-(2,2,2-Trifluoroethyl)piperazine dihydrochloride 13349-91-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-25