1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]-
- Product Name
- 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]-
- CAS No.
- 348640-02-8
- Chemical Name
- 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]-
- Synonyms
- N-Tosyl-7-azaindole;1-(4-methylphenyl)sulfonylpyrrolo[2,3-b]pyridine;1-[(4-methylphenyl)sulphonyl]-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]-
- CBNumber
- CB61871764
- Molecular Formula
- C14H12N2O2S
- Formula Weight
- 272.32
- MOL File
- 348640-02-8.mol
1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]- Property
- Melting point:
- 132-133℃
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
N-Bromosuccinimide Price
- Product number
- 020020
- Product name
- 1-(Toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine
- Purity
- 98+%
- Packaging
- 250mg
- Price
- $44
- Updated
- 2021/12/16
- Product number
- 020020
- Product name
- 1-(Toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine
- Purity
- 98+%
- Packaging
- 500mg
- Price
- $73
- Updated
- 2021/12/16
- Product number
- 4254AB
- Product name
- 1-Tosyl-1H-pyrrolo[2,3-b]pyridine
- Packaging
- 250mg
- Price
- $88
- Updated
- 2021/12/16
- Product number
- 4254AB
- Product name
- 1-Tosyl-1H-pyrrolo[2,3-b]pyridine
- Packaging
- 1g
- Price
- $109
- Updated
- 2021/12/16
- Product number
- CHM0082943
- Product name
- 1-(TOLUENE-4-SULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $858.17
- Updated
- 2021/12/16
1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]- Chemical Properties,Usage,Production
Synthesis
271-63-6
98-59-9
348640-02-8
1. To a stirred solution of 7-azaindole (6.0 g, 50.0 mmol, 1.0 eq.) in THF (20 mL) at 0 °C was slowly added NaH (60% dispersion, 2.2 g, 66.0 mmol, 1.3 eq.). 2. The reaction mixture was gradually warmed to room temperature and stirred continuously for 30 minutes. 3. After the reaction mixture was cooled to 0 °C again, p-toluenesulfonyl chloride (TsCl, 11.6 g, 60.0 mmol, 1.2 eq.) was added. 4. The reaction mixture was stirred at room temperature overnight. 5. Upon completion of the reaction, the reaction was quenched with water and extracted with ethyl acetate (EtOAc). 6. The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to remove the solvent. 7. Purification of the crude product by column chromatography (eluent: hexane/ethyl acetate gradient) afforded 1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine (Intermediate 1a) as a white solid (12.8 g, 93% yield, 100% UPLC purity).
References
[1] Patent: US2018/179199, 2018, A1. Location in patent: Paragraph 0445-0446
[2] Angewandte Chemie - International Edition, 2016, vol. 55, # 39, p. 11859 - 11862
[3] Angew. Chem., 2016, vol. 128, p. 12038 - 12041,4
[4] Chemistry Letters, 2011, vol. 40, # 6, p. 555 - 557
[5] Patent: US2009/318455, 2009, A1. Location in patent: Page/Page column 98-99
1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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