4-Chloro-5-fluoroindole
- Product Name
- 4-Chloro-5-fluoroindole
- CAS No.
- 169674-02-6
- Chemical Name
- 4-Chloro-5-fluoroindole
- Synonyms
- 4-Chloro-5-fluoroindole;4-chloro-5-fluoro-1H-indole;1H-Indole, 4-chloro-5-fluoro-
- CBNumber
- CB61874684
- Molecular Formula
- C8H5ClFN
- Formula Weight
- 169.58
- MOL File
- 169674-02-6.mol
4-Chloro-5-fluoroindole Property
- Melting point:
- 21-22 °C(Solv: hexane (110-54-3))
- Boiling point:
- 300 ºC
- Density
- 1.436
- Flash point:
- 135 ºC
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 15.26±0.30(Predicted)
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- PC201168
- Product name
- 4-Chloro-5-fluoro-1H-indole
- Purity
- 97%
- Packaging
- 100mg
- Price
- $295
- Updated
- 2021/12/16
- Product number
- 3H31-7-2U
- Product name
- 4-Chloro-5-fluoro-1H-indole
- Purity
- 97%
- Packaging
- 100mg
- Price
- $472
- Updated
- 2021/12/16
- Product number
- PC201168
- Product name
- 4-Chloro-5-fluoro-1H-indole
- Purity
- 97%
- Packaging
- 250mg
- Price
- $522
- Updated
- 2021/12/16
- Product number
- 3H31-7-2U
- Product name
- 4-Chloro-5-fluoro-1H-indole
- Purity
- 97%
- Packaging
- 1g
- Price
- $927
- Updated
- 2021/12/16
- Product number
- 3H31-7-2U
- Product name
- 4-Chloro-5-fluoro-1H-indole
- Purity
- 97%
- Packaging
- 250mg
- Price
- $836
- Updated
- 2021/12/16
4-Chloro-5-fluoroindole Chemical Properties,Usage,Production
Synthesis
908600-95-3
169674-02-6
The general procedure for the synthesis of 4-chloro-5-fluoroindole using the compound (CAS: 908600-95-3) as starting material was as follows: tetrabutylammonium fluoride hydrate (1.9 g, 7.38 mmol) was dissolved in THF (30 mL) along with compound 2 (1.2 g, 3.69 mmol), and the reaction was stirred for 30 min at room temperature. After completion of the reaction, the reaction mixture was diluted with ether (30 mL), followed by washing with brine (30 mL), drying with anhydrous sodium sulfate, filtering to remove the desiccant, and the filtrate was concentrated under reduced pressure to remove the solvent. Finally, purification by column chromatography (eluent: petroleum ether/ethyl acetate = 50:1) afforded compound 3 (0.5 g, 80.1% yield) as a brown oil.
References
[1] European Journal of Organic Chemistry, 2006, # 13, p. 2956 - 2969
[2] Patent: US2016/9706, 2016, A1. Location in patent: Paragraph 0354; 0357
4-Chloro-5-fluoroindole Preparation Products And Raw materials
Raw materials
Preparation Products
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