D(-)-Glutamic acid Property

Melting point:

200-202 °C (subl.)(lit.)

alpha 

-31.3 º (c=10, 2 N HCl)

Boiling point:

267.21°C (rough estimate)

Density 

1.5380

refractive index 

1.4210 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Water (Slightly)

form 

Powder

pka

pK1:2.162(＋1);pK2:4.272(0);pK3:9.358(－1) (25°C)

color 

White to off-white

Water Solubility 

7 g/L (20 ºC)

Merck 

14,4469

BRN 

1723800

InChIKey

WHUUTDBJXJRKMK-GSVOUGTGSA-N

LogP

-0.969 (est)

CAS DataBase Reference

6893-26-1(CAS DataBase Reference)

NIST Chemistry Reference

D-Glutamic acid(6893-26-1)

EPA Substance Registry System

D-Glutamic acid (6893-26-1)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

24/25-36-26

WGK Germany 

3

F 

10

TSCA 

Yes

HS Code 

29224200

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

D(-)-Glutamic acid Chemical Properties,Usage,Production

Chemical Properties

White cryst. powder

Uses

D-Glutamic Acid is the unnatural (R)-enantiomer of Glutamic Acid, a non-essential amino acid. Its salt form (glutamate) is an important neurotransmitter that plays a key role in long-term potentiation and is important for learning and memory. Glutamic Acid is also a key molecule in cellular metabolism.

Uses

D-Glutamic acid acts as a superior to alpha ketoglutarate. It helps in the growth of Lactobacillus arabinosus. It can inhibit the IgE binding to peanut allergens. It is widely used in pharmaceuticals and foods.

Uses

D-glutamic acid is suitable for use in the structure-affinity relationship (SAR)-study of GR (glutamate racemase) enzyme and its inhibitors.

Definition

ChEBI: An optically active form of glutamic acid having D-configuration.

General Description

D-Glutamic acid is an essential constituent of the bacterial peptidoglycan structure. It is added to UDP-N-acetylmuramyl-L-alanine (UDP-MurNAc-L-alanine) by the enzyme D-glutamic acid-adding enzyme (murD). This is, then, incorporated into the peptidoglycan precursor. Peptidoglycan makes up the cell walls of Gram-positive and -negative bacteria. The conversion of L-glutamate to D-glutamate by glutamate racemase (GR) enzyme is an essential step in the synthesis of peptidoglycan.

Biological Activity

Excitatory amino acid acting at NMDA receptors; less active than the L-isomer.

Biochem/physiol Actions

Unnatural isomer of glutamic acid.

storage

Room temperature