BENZYL N-(2-HYDROXYETHYL)CARBAMATE

Product Name: BENZYL N-(2-HYDROXYETHYL)CARBAMATE
CAS No.: 77987-49-6
Chemical Name: BENZYL N-(2-HYDROXYETHYL)CARBAMATE
Synonyms: Benzyl (2-hydroxyethyl)carbaMate;2-(CARBOBENZOXYAMINO)-1-ETHANOL;Z-GLY-OL;Z-GLYCINOL;Cbz-Gly-OL;Z-NH-(CH2)2-OH;Z-ETHANOLAMINE;Z-AMINOETHANOL;N-CBZ-GLYCINOL;N-Z-ETHANOLAMINE
CBNumber: CB6201850
Molecular Formula: C10H13NO3
Formula Weight: 195.22
MOL File: 77987-49-6.mol

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BENZYL N-(2-HYDROXYETHYL)CARBAMATE Property

Melting point:: 58-60 °C (lit.)
Boiling point:: 215 °C/15 mmHg (lit.)
Density: 1.1926 (rough estimate)
refractive index: 1.5150 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in water or 1% acetic acid
pka: 11.80±0.46(Predicted)
form: Powder
color: White
BRN: 2050891
InChI: InChI=1S/C10H13NO3/c12-7-6-11-10(13)14-8-9-4-2-1-3-5-9/h1-5,12H,6-8H2,(H,11,13)
InChIKey: SAGINAGERRNGGV-UHFFFAOYSA-N
SMILES: C(OCC1=CC=CC=C1)(=O)NCCO
CAS DataBase Reference: 77987-49-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29221985

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 407909
Product name: N-Z-Ethanolamine
Purity: 98%
Packaging: 5g
Price: $35
Updated: 2023/06/20

Sigma-Aldrich

Product number: 407909
Product name: N-Z-Ethanolamine
Purity: 98%
Packaging: 25g
Price: $40
Updated: 2023/06/20

TCI Chemical

Product number: H0793
Product name: 2-(Carbobenzoxyamino)-1-ethanol
Purity: >97.0%(GC)
Packaging: 5g
Price: $58
Updated: 2025/07/31

TCI Chemical

Product number: H0793
Product name: 2-(Carbobenzoxyamino)-1-ethanol
Purity: >97.0%(GC)
Packaging: 25g
Price: $230
Updated: 2025/07/31

Sigma-Aldrich

Product number: 407909
Product name: N-Z-Ethanolamine
Purity: 98%
Packaging: 100g
Price: $110
Updated: 2023/06/20

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BENZYL N-(2-HYDROXYETHYL)CARBAMATE Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

N-(Benzyloxycarbonyl)ethanolamine is an intermediate used to prepare alkynylaryladenines as A2A adenosine receptor agonists and effects on hepatic glucose production. It is also used in the synthesis of functionalized N-arylaminoethyl amides as noncovalent inhibitors of cathepsin S.

reaction suitability

reagent type: cross-linking reagent

Synthesis

141-43-5

501-53-1

77987-49-6

(1) Synthesis of benzyl [2-(tert-butyldiphenylmethoxysilyl)ethyl]carbamate [1515]: To a solution of 2-aminoethanol (2.0 g, 32.7 mmol) in dichloromethane (60 mL), benzyl chloroformate (5.6 mL, 41.3 mmol) and triethylamine (5.5 mL, 39.5 mmol) were sequentially added under ice bath conditions. The reaction mixture was stirred at room temperature for 1 hour. After completion of the reaction, the mixture was partitioned between ethyl acetate and saturated aqueous sodium chloride solution. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent being toluene:acetonitrile (3:2) to afford benzyl (2-hydroxyethyl)carbamate (5.37 g, 84% yield) as a white solid. [1516] Subsequently, to a solution of benzyl (2-hydroxyethyl)carbamate (5.37 g, 27.5 mmol) in dimethylformamide (160 mL) was added tert-butyldiphenylmethylsilyl chloride (8.6 mL, 33.0 mmol) and imidazole (2.3 g, 33.8 mmol) under ice bath conditions. The mixture was stirred at room temperature overnight. After the reaction was complete, ethanol was added and stirring was continued for 2 hours. The reaction mixture was partitioned between ethyl acetate and saturated aqueous sodium bicarbonate. The organic layer was washed with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with hexane:ethyl acetate (5:1) as eluent to give benzyl [2-(tert-butyldiphenylmethylsilylmethoxy)ethyl]carbamate (11.93 g, 100% yield) as a colorless transparent syrup. [1517] 1H-NMR (400 MHz, CDCl3): δ (ppm) 7.64 (4H, d, J = 6.8 Hz), 7.46-7.28 (12H, m), 5.10 (2H, s), 3.73 (2H, t, J = 4.9 Hz), 3.35 (2H, q, J = 4.9 Hz), 1.05 (9H, s).

References

[1] Patent: US2004/14962, 2004, A1. Location in patent: Page/Page column 137
[2] Journal of Organic Chemistry, 1987, vol. 52, # 7, p. 1252 - 1255
[3] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 15, p. 1749 - 1750
[4] Tetrahedron Letters, 2007, vol. 48, # 46, p. 8170 - 8173
[5] Tetrahedron, 1991, vol. 47, # 14/15, p. 2591 - 2602

BENZYL N-(2-HYDROXYETHYL)CARBAMATE Preparation Products And Raw materials

Raw materials

Preparation Products

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BENZYL N-(2-HYDROXYETHYL)CARBAMATE Suppliers

Americas 1 China 127 Europe 1 Germany 5 India 3 Japan 2 Switzerland 3 The Netherlands 1 United Kingdom 4 United States 31 Global 178

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View Lastest Price from BENZYL N-(2-HYDROXYETHYL)CARBAMATE manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Cbz-Gly-ol 77987-49-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-01-15

Sichuan Jiaying Lai Technology Co.,LTD

Product: Z-Gly-ol 77987-49-6
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2019-07-29

Career Henan Chemical Co

Product: BENZYL N-(2-HYDROXYETHYL)CARBAMATE 77987-49-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-02

77987-49-6, BENZYL N-(2-HYDROXYETHYL)CARBAMATERelated Search:

N-Cbz-L-glutamic acid N-Cbz-L-Serine Nalpha-Cbz-L-Arginine Z-CYS(BZL)-OH N-Cbz-L-Phenylalanine Z-SER(BZL)-OH N-Carbobenzyloxy-L-alanine N-Carbobenzyloxy-L-aspartic acid N-Carbobenzyloxy-L-valine N-Carbobenzyloxyglycine Z-AIB-OH N-Benzyloxycarbonyl-L-asparagine Z-D-PHG-OH N-Carbobenzyloxy-L-glutamine Z-SAR-OH N-CARBOBENZOXY-DL-NORVALINE Z-L-PROLINE Z-PRO-ONP

Z-AMINOETHANOL

Z-ETHANOLAMINE

Z-GLY-OL

Z-GLYCINOL

Z-NH-(CH2)2-OH

2-(CBZ-AMINO)-1-ETHANOL

2-(CARBOBENZOXYAMINO)-1-ETHANOL

2-(Z-AMINO)-ETHANOL

N-CARBOBENZOXY-2-AMINOETHANOL

N-CARBOBENZOXY-GLYCINOL

N-Z-ETHANOLAMINE

N-(2-HYDROXYETHYL)CARBAMIC ACID BENZYL ESTER

BENZYL N-(2-HYDROXYETHYL)CARBAMATE

LABOTEST-BB LT00452296

N-CBZ-GLYCINOL

2-(Z-Amino)ethanol, Benzyl N-(2-hydroxyethyl)carbamate

2-(Benzyloxycarbonylamino)-1-ethanol

Benzyl N-(2-Hydroxyethyl)carbamate 2-(Cbz-amino)-1-ethanol N-(2-Hydroxyethyl)carbamic Acid Benzyl Ester

N-(2-hydroxyethyl)carbamic acid (phenylmethyl) ester

Benzyl (2-hydroxyethyl)carbaMate

N-Z-EthanolaMine 98%

Cbz-Gly-OL

(2-Hydroxy-ethyl)-carbamic acid benzyl ester

Z-Glycinol≥ 99% (HPLC)

2-(Cbz-amino)ethanol

N - (benzyloxycarbonylamino) - 1-ethanol

2-(Carbobenzoxyamino)-1-ethanol&gt

Carbamic acid, N-(2-hydroxyethyl)-, phenylmethyl ester

BENZYL N-(2-HYDROXYETHYL)CARBAMATE USP/EP/BP

<i>N</i>-Z-Ethanolamine

77987-49-6

HOCH2CH2NHCO2CH2C6H5

Oxygen Compounds

Organic Building Blocks

Building Blocks

Amino Alcohols

Z-Amino acid series

Amino Alcohols

Bifunctional Crosslinkers

Building Blocks

Chemical Biology

Chemical Synthesis

Linkers

Organic Building Blocks

Oxygen Compounds

Peptide Chemistry

Cbz-PEG