humanin

Product Name: humanin
CAS No.: 330936-69-1
Chemical Name: humanin
Synonyms: HUMANIN;HN;Humanin S14-G;Humanin, HN;Humanin (1);HUMANIN (HUMAN);Humanin(human) acetate;Protein humanin (human);MAPGSGCLLLLTSEIDLPVKRRA;HUMANIN TRIFLUOROACETATE
CBNumber: CB6205843
Molecular Formula: C119H204N34O32S2
Formula Weight: 2687.27
MOL File: 330936-69-1.mol

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humanin Property

Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: −20°C
form: solid
color: White to off-white
Sequence: Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
InChIKey: DPEUWKZJZIPZKE-YSUKGSMWNA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J66525
Product name: Humanin, human
Packaging: 5mg
Price: $481
Updated: 2023/06/20

Cayman Chemical

Product number: 24150
Product name: Humanin
Purity: ≥95%
Packaging: 500μg
Price: $149
Updated: 2021/12/16

Cayman Chemical

Product number: 24150
Product name: Humanin
Purity: ≥95%
Packaging: 1mg
Price: $268
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb372420
Product name: Humanin
Purity: > 95%
Packaging: 1mg
Price: $552.5
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0000121
Product name: [D-SER14]-HUMANIN (HN)
Purity: 95.00%
Packaging: 0.5MG
Price: $823.52
Updated: 2021/12/16

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humanin Chemical Properties,Usage,Production

General Description

Humanin (HN) is a natural short mitochondrial polypeptide with antiapoptotic and neuroprotective effects. Humanin protects cells against various diseases, including oxidative stress and cytotoxicity induced by various stimuli with broad-spectrum activity on the pancreas, brain, testis, and heart.

Biological Activity

Humanin (HN/MTRNR2) has also been cloned as a BAX partner that could suppress apoptosis caused by staurosporine, serum deprivation, or u.v. irradiation. Using co-immunoprecipitation experiments, humanin specifically bound to BAX, tBID, and BimEL (BCL2L11), but not other BCL2 family proteins such as BCL2 and BCL-B (BCL2L10). Furthermore, the anti-apoptotic effect of humanin was specific to BAX-dependent apoptosis, as apoptosis by a BAX-independent stimulus, such as the use of tumor necrosis factor, was not suppressed. Humanin also interacts with insulin-like growth factor-binding protein 3 (IGFBP3), where it can block IGFBP3-induced apoptosis in glial cell lines but not in neuronal cell lines or primary neurons[1].

Biochem/physiol Actions

Humanin is 24-amino acid mitochondria-associated peptide that is involved in numerous biological processes including apoptosis, cell survival, substrate metabolism, inflammatory response, and response to stressors such as oxidative stress, ischemia, and starvation. Humanin exhibits protective effects against cellular apoptosis. Apparently it inhibits BAX translocation to the mitochondrial outer membrane.

References

[1] Kelvin Yen. “The emerging role of the mitochondrial-derived peptide humanin in stress resistance.” Journal of molecular endocrinology 50 1 (2013): R11-9.

humanin Preparation Products And Raw materials

Raw materials

Preparation Products

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humanin Suppliers

China 97 France 1 Japan 1 Switzerland 2 United States 11 Global 112

NeoMPS SA

Tel: --
Fax: --
Email: neo@neomps.com
Country: France
ProdList: 2083
Advantage: 71

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View Lastest Price from humanin manufacturers

Dorne Chemical Technology co. LTD

Product: HUMANIN TRIFLUOROACETATE 330936-69-1
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2024-03-26

hebei hongtan Biotechnology Co., Ltd

Product: Humanin HN 330936-69-1
Price: US $30.00-100.00/g
Min. Order: 10g
Purity: 98%
Supply Ability: 2000kg
Release date: 2024-06-05

Shanghai Affida new material science and technology center

Product: Humanin 330936-69-1
Price: US $0.00-0.00/Box
Min. Order: 1Box
Purity: 99
Supply Ability: 50000KG/month
Release date: 2024-04-15

330936-69-1, humaninRelated Search:

ANSERINE Thymine Nesiritide acetate PNC27 peptide Elcatonin Glycyl-L-prolyl-L-arginyl-L-prolyl-L-alaninamide Pentapeptide-18 L-Lysyl-L-alpha-aspartyl-L-valyl-N5-(aminocarbonyl)-L-ornithine Rigin L-Carnosine L-Leu-Leu-Leu GLY-PHE-SER [GLY14]-HUMANIN TRIFLUOROACETATE HUMANIN TRIFLUOROACETATE [125I]-HUMANIN (HUMAN)

MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-SER-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA

MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-SER-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA TRIFLUOROACETATE

MAPRGFSCLLLLTSEIDLPVKRRA

HN

HNMET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-SER-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA

H-MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-SER-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA-OH

H-MAPRGFSCLLLLTSEIDLPVKRRA-OH

Humanin S14-G

HUMANIN (HUMAN)

HUMANIN

HUMANIN TRIFLUOROACETATE

1-24-Protein humanin (human)

L-Alanine, L-methionyl-L-alanyl-L-prolyl-L-arginylglycyl-L-phenylalanyl-L-seryl-L-cysteinyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonyl-L-seryl-L- alpha-glutamyl-L-isoleucyl-L-alpha-aspartyl-L-leucyl-L-prolyl-L-valyl-L-lysyl-L-arginyl-L-arginyl-

Protein (human clone 1 humanin sequence homolog)

Protein humanin (human)

T Lymphocyte activation-associated protein Pro86272 (human)

Humanin, HN

Humanin (1)

MAPGSGCLLLLTSEIDLPVKRRA

Drepanopeziza populorum (Desm.) H&ouml

Leucostoma persoonii (Nitschke) H&ouml

L-Alanine, L-methionyl-L-alanyl-L-prolyl-L-arginylglycyl-L-phenylalanyl-L-seryl-L-cysteinyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonyl-L-seryl-L-α-glutamyl-L-isoleucyl-L-α-aspartyl-L-leucyl-L-prolyl-L-valyl-L-lysyl-L-arginyl-L-arginyl-

Humanin(human)trifluoroacetate

Humanin(human) acetate

330936-69-1

C119H203N34O32S2

C119H204N34O32S2

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