2-CHLOROQUINOLINE-4-CARBOXYLIC ACID
- Product Name
- 2-CHLOROQUINOLINE-4-CARBOXYLIC ACID
- CAS No.
- 5467-57-2
- Chemical Name
- 2-CHLOROQUINOLINE-4-CARBOXYLIC ACID
- Synonyms
- Nsc25654;AKOS BB-6908;2-Chlorocinchoninic acid;A-CHLORO CINCHONINIC ACID;2-CHLORO-4-CARBOXY QUINOLINE;2-Chloroquinoline-4-CarboxylicAci;2-Chloro-4-quinolinecarboxylic acid;2-CHLOROQUINOLINE-4-CARBOXYLIC ACID;4-Quinolinecarboxylic acid, 2-chloro-;2-Chloroquinoline-4-carboxylic Acid >
- CBNumber
- CB6208905
- Molecular Formula
- C10H6ClNO2
- Formula Weight
- 207.61
- MOL File
- 5467-57-2.mol
2-CHLOROQUINOLINE-4-CARBOXYLIC ACID Property
- Melting point:
- 244 °C
- Boiling point:
- 368.7±22.0 °C(Predicted)
- Density
- 1.469±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 2.17±0.10(Predicted)
- color
- White to Orange to Green
- InChI
- InChI=1S/C10H6ClNO2/c11-9-5-7(10(13)14)6-3-1-2-4-8(6)12-9/h1-5H,(H,13,14)
- InChIKey
- ICNCOMYUODLTAI-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC=CC=2)C(C(O)=O)=CC=1Cl
- CAS DataBase Reference
- 5467-57-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 2933491090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- C1703
- Product name
- 2-Chloroquinoline-4-carboxylic Acid
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $155
- Updated
- 2025/07/31
- Product number
- C1703
- Product name
- 2-Chloroquinoline-4-carboxylic Acid
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $569
- Updated
- 2025/07/31
- Product number
- C381460
- Product name
- 2-Chloroquinoline-4-carboxylic Acid
- Packaging
- 5g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- FC15904
- Product name
- 2-Chloroquinoline-4-carboxylic acid
- Packaging
- 100g
- Price
- $1155
- Updated
- 2021/12/16
- Product number
- FC15904
- Product name
- 2-Chloroquinoline-4-carboxylic acid
- Packaging
- 25g
- Price
- $394
- Updated
- 2021/12/16
2-CHLOROQUINOLINE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
2-Chloroquinoline-4-carboxylic Acid is an intermediate used to prepare dimethyl(naphthalenecarbonyl)aminobenzoic acids as potent and selective EP4 antagonists.
Synthesis
15733-89-8
5467-57-2
The general procedure for the synthesis of 2-chloroquinoline-4-carboxylic acid from 2-quinolone-4-carboxylic acid was as follows: 2-hydroxyquinoline-4-carboxylic acid (2.57 g, 13.6 mmol) was mixed with phosphorus oxytriphosphate (POCl3, 25 mL) and heated and refluxed for 24 hours. Upon completion of the reaction, the reaction mixture was quenched by slowly pouring it into crushed ice (300 g). The precipitated solid was separated by filtration, washed thoroughly with deionized water and dried under high vacuum to give 2.47 g of white solid product in 87% yield. The product was characterized by 1H NMR (CDCl3, 300 MHz) and LCMS: 1H NMR δ 8.67 (d, 1H, J = 8.4 Hz), 7.91 (d, 1H, J = 8.1 Hz), 7.83 (s, 1H), 7.67 (t, 1H, J = 7.2 Hz), 7.54 (t, 1H, J = 7.2 Hz); LCMS (m/ z): 208 ([M+H]+).
References
[1] Patent: WO2005/30774, 2005, A1. Location in patent: Page/Page column 23
[2] Journal of the American Chemical Society, 1946, vol. 68, p. 1837,1838
[3] Proceedings of the Royal Society of London, Series B: Biological Sciences, 1938, vol. 125, p. 60,69
2-CHLOROQUINOLINE-4-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2-CHLOROQUINOLINE-4-CARBOXYLIC ACID Suppliers
- Tel
- --
- Fax
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- info@specs.net
- Country
- The Netherlands
- ProdList
- 6833
- Advantage
- 70
View Lastest Price from 2-CHLOROQUINOLINE-4-CARBOXYLIC ACID manufacturers
- Product
- 2-CHLOROQUINOLINE-4-CARBOXYLIC ACID 5467-57-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2021-10-15
- Product
- 2-CHLOROQUINOLINE-4-CARBOXYLIC ACID 5467-57-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 85.0-99.8%
- Supply Ability
- 20ton
- Release date
- 2019-12-20