4-(Trifluoromethoxy)fluorobenzene

Product Name: 4-(Trifluoromethoxy)fluorobenzene
CAS No.: 352-67-0
Chemical Name: 4-(Trifluoromethoxy)fluorobenzene
Synonyms: 1-FLUORO-4-(TRIFLUOROMETHOXY)BENZENE;uoro-4-(trifL;P-FLUORO(TRIFLUOROMETHOXY)BENZENE;4-(TRIFLUOROMETHOXY)FLUOROBENZENE;4-FLUORO(TRIFLUOROMETHOXY)BENZENE;p-(Trifluoromethoxy)fluorobenzene;4- hydroxyl -3-Methyl acetophenone;4-(TRIFLUOROMETHOXY)-1-FLUORBENZENE;4-(Trifluoromethoxy)phenyl fluoride;4-Fluorophenyl trifluoromethyl ether
CBNumber: CB6209447
Molecular Formula: C7H4F4O
Formula Weight: 180.1
MOL File: 352-67-0.mol

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4-(Trifluoromethoxy)fluorobenzene Property

Boiling point:: 104-105 °C(lit.)
Density: 1.323 g/mL at 25 °C(lit.)
refractive index: n20/D 1.394(lit.)
Flash point:: 60 °F
storage temp.: Store below +30°C.
form: liquid
Specific Gravity: 1.323
color: Clear, colourless
Water Solubility: Not miscible or difficult to mix in water.
BRN: 2046330
InChI: InChI=1S/C7H4F4O/c8-5-1-3-6(4-2-5)12-7(9,10)11/h1-4H
InChIKey: JULMJGDXANEQDP-UHFFFAOYSA-N
SMILES: C1(F)=CC=C(OC(F)(F)F)C=C1
CAS DataBase Reference: 352-67-0(CAS DataBase Reference)
NIST Chemistry Reference: P-fluorophenyl trifluoromethyl ether(352-67-0)

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Safety

Hazard Codes: F,Xi
Risk Statements: 11-36/37/38
Safety Statements: 16-26-36/37/39
RIDADR: UN 1993 3/PG 2
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 3
PackingGroup: II
HS Code: 29093090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.41175
Product name: 4-(Trifluoromethoxy)-1-fluorobenzene
Purity: for synthesis
Packaging: 1mL
Price: $108
Updated: 2025/07/31

TRC

Product number: F598938
Product name: 1-Fluoro-4-(trifluoromethoxy)benzene
Packaging: 2.5g
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: PC4370D
Product name: 1-Fluoro-4-(trifluoromethoxy)benzene
Packaging: 100g
Price: $67
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2607-3-41
Product name: 1-Fluoro-4-(trifluoromethoxy)benzene
Purity: 99%
Packaging: 100g
Price: $74
Updated: 2021/12/16

Matrix Scientific

Product number: 008766
Product name: 4-(Trifluoromethoxy)fluorobenzene
Purity: 98%
Packaging: 100g
Price: $63
Updated: 2021/12/16

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4-(Trifluoromethoxy)fluorobenzene Chemical Properties,Usage,Production

Uses

It is employed as an active pharmaceutical intermediate.

Synthesis

338792-64-6

352-67-0

The general procedure for the synthesis of p-fluorotrifluoromethoxybenzene from 2,2-difluoro-2-(4-fluorophenoxy)acetic acid was as follows: a stir bar was added to a 5 mL microwave vial in an argon-protected glove box and sealed. Selectfluor (177.1 mg, 0.5 mmol, 2.0 eq.), silver trifluoromethanesulfonate (12.8 mg, 0.05 mmol, 20 mol%), and 2,2-difluoro-2-(4-fluorophenoxy)acetic acid (0.25 mmol, 1.0 eq.) were added sequentially. The vial was charged with dichloromethane (1.8 mL), trifluoroacetic acid (76.5 μL, 1.0 mmol, 4.0 equiv) and water (0.2 mL). The reaction mixture was heated at 55 °C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature, diluted with dichloromethane (4 mL), washed sequentially with water (3 x 5 mL) and brine (5 mL), dried over anhydrous magnesium sulfate and filtered. The dried organic phase was concentrated on a rotary evaporator. The crude product obtained was dissolved in a small amount of dichloromethane and purified by passing through a silica gel column (10 g, Biotage), first dried with air and then eluted with pentane. The fractions containing the pure product were combined and the solvent evaporated to give pure p-fluorotrifluoromethoxybenzene.

References

[1] Organic Letters, 2016, vol. 18, # 15, p. 3754 - 3757
[2] Organic Letters, 2016, vol. 18, # 18, p. 4570 - 4573
[3] Angewandte Chemie - International Edition, 2016, vol. 55, # 33, p. 9758 - 9762
[4] Angew. Chem., 2016, vol. 128, # 33, p. 9910 - 9914,5
[5] Journal of Fluorine Chemistry, 2017, vol. 203, p. 130 - 135

4-(Trifluoromethoxy)fluorobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(Trifluoromethoxy)fluorobenzene Suppliers

Canada 1 China 167 Europe 2 France 1 Germany 5 India 2 Italy 1 Japan 2 South Korea 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 14 United States 28 Global 227

Alfa Aesar

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Shanghai Longsheng chemical Co.,Ltd.

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Nanjing Chemlin Chemical Co., Ltd

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View Lastest Price from 4-(Trifluoromethoxy)fluorobenzene manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-(Trifluoromethoxy)fluorobenzene 352-67-0
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%
Supply Ability: 2000tons
Release date: 2020-01-16

Career Henan Chemical Co

Product: 4-(Trifluoromethoxy)fluorobenzene 352-67-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-06-25

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