4-(Trifluoromethoxy)fluorobenzene
- Product Name
- 4-(Trifluoromethoxy)fluorobenzene
- CAS No.
- 352-67-0
- Chemical Name
- 4-(Trifluoromethoxy)fluorobenzene
- Synonyms
- 1-FLUORO-4-(TRIFLUOROMETHOXY)BENZENE;uoro-4-(trifL;P-FLUORO(TRIFLUOROMETHOXY)BENZENE;4-(TRIFLUOROMETHOXY)FLUOROBENZENE;4-FLUORO(TRIFLUOROMETHOXY)BENZENE;p-(Trifluoromethoxy)fluorobenzene;4- hydroxyl -3-Methyl acetophenone;4-(TRIFLUOROMETHOXY)-1-FLUORBENZENE;4-(Trifluoromethoxy)phenyl fluoride;4-Fluorophenyl trifluoromethyl ether
- CBNumber
- CB6209447
- Molecular Formula
- C7H4F4O
- Formula Weight
- 180.1
- MOL File
- 352-67-0.mol
4-(Trifluoromethoxy)fluorobenzene Property
- Boiling point:
- 104-105 °C(lit.)
- Density
- 1.323 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.394(lit.)
- Flash point:
- 60 °F
- storage temp.
- Store below +30°C.
- form
- liquid
- Specific Gravity
- 1.323
- color
- Clear, colourless
- Water Solubility
- Not miscible or difficult to mix in water.
- BRN
- 2046330
- InChI
- InChI=1S/C7H4F4O/c8-5-1-3-6(4-2-5)12-7(9,10)11/h1-4H
- InChIKey
- JULMJGDXANEQDP-UHFFFAOYSA-N
- SMILES
- C1(F)=CC=C(OC(F)(F)F)C=C1
- CAS DataBase Reference
- 352-67-0(CAS DataBase Reference)
- NIST Chemistry Reference
- P-fluorophenyl trifluoromethyl ether(352-67-0)
Safety
- Hazard Codes
- F,Xi
- Risk Statements
- 11-36/37/38
- Safety Statements
- 16-26-36/37/39
- RIDADR
- UN 1993 3/PG 2
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 3
- PackingGroup
- II
- HS Code
- 29093090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
N-Bromosuccinimide Price
- Product number
- 8.41175
- Product name
- 4-(Trifluoromethoxy)-1-fluorobenzene
- Purity
- for synthesis
- Packaging
- 1mL
- Price
- $108
- Updated
- 2025/07/31
- Product number
- F598938
- Product name
- 1-Fluoro-4-(trifluoromethoxy)benzene
- Packaging
- 2.5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- PC4370D
- Product name
- 1-Fluoro-4-(trifluoromethoxy)benzene
- Packaging
- 100g
- Price
- $67
- Updated
- 2021/12/16
- Product number
- 2607-3-41
- Product name
- 1-Fluoro-4-(trifluoromethoxy)benzene
- Purity
- 99%
- Packaging
- 100g
- Price
- $74
- Updated
- 2021/12/16
- Product number
- 008766
- Product name
- 4-(Trifluoromethoxy)fluorobenzene
- Purity
- 98%
- Packaging
- 100g
- Price
- $63
- Updated
- 2021/12/16
4-(Trifluoromethoxy)fluorobenzene Chemical Properties,Usage,Production
Uses
It is employed as an active pharmaceutical intermediate.
Synthesis
338792-64-6
352-67-0
The general procedure for the synthesis of p-fluorotrifluoromethoxybenzene from 2,2-difluoro-2-(4-fluorophenoxy)acetic acid was as follows: a stir bar was added to a 5 mL microwave vial in an argon-protected glove box and sealed. Selectfluor (177.1 mg, 0.5 mmol, 2.0 eq.), silver trifluoromethanesulfonate (12.8 mg, 0.05 mmol, 20 mol%), and 2,2-difluoro-2-(4-fluorophenoxy)acetic acid (0.25 mmol, 1.0 eq.) were added sequentially. The vial was charged with dichloromethane (1.8 mL), trifluoroacetic acid (76.5 μL, 1.0 mmol, 4.0 equiv) and water (0.2 mL). The reaction mixture was heated at 55 °C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature, diluted with dichloromethane (4 mL), washed sequentially with water (3 x 5 mL) and brine (5 mL), dried over anhydrous magnesium sulfate and filtered. The dried organic phase was concentrated on a rotary evaporator. The crude product obtained was dissolved in a small amount of dichloromethane and purified by passing through a silica gel column (10 g, Biotage), first dried with air and then eluted with pentane. The fractions containing the pure product were combined and the solvent evaporated to give pure p-fluorotrifluoromethoxybenzene.
References
[1] Organic Letters, 2016, vol. 18, # 15, p. 3754 - 3757
[2] Organic Letters, 2016, vol. 18, # 18, p. 4570 - 4573
[3] Angewandte Chemie - International Edition, 2016, vol. 55, # 33, p. 9758 - 9762
[4] Angew. Chem., 2016, vol. 128, # 33, p. 9910 - 9914,5
[5] Journal of Fluorine Chemistry, 2017, vol. 203, p. 130 - 135
4-(Trifluoromethoxy)fluorobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
4-(Trifluoromethoxy)fluorobenzene Suppliers
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- Country
- Japan
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View Lastest Price from 4-(Trifluoromethoxy)fluorobenzene manufacturers
- Product
- 4-(Trifluoromethoxy)fluorobenzene 352-67-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%
- Supply Ability
- 2000tons
- Release date
- 2020-01-16
- Product
- 4-(Trifluoromethoxy)fluorobenzene 352-67-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-06-25