ChemicalBook > CAS DataBase List > 6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID

6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID

Product Name
6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID
CAS No.
33458-93-4
Chemical Name
6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID
Synonyms
AH 6809;AH6809;AH-6809;6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID;6-ISOPROPOXY-9-OXOXANTHENE-2-CARBOXYLIC ACID;6-Isopropoxy-9-oxo-9H-xanthene-2-carboxylic acid;6-(1-Methylethoxy)-9-oxo-9H-xanthene-2-carboxylic acid;9-oxo-6-(propan-2-yloxy)-9H-xanthene-2-carboxylic acid;9H-Xanthene-2-carboxylic acid, 6-(1-methylethoxy)-9-oxo-;Prostaglandin Receptor,AH-6809,inhibit,Inhibitor,AH6809,AH 6809
CBNumber
CB6209962
Molecular Formula
C17H14O5
Formula Weight
298.29
MOL File
33458-93-4.mol
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6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID Property

storage temp. 
Sealed in dry,Room Temperature
solubility 
ethanol: 2.5 mg/mL, soluble
form 
crystalline solid or supercooled liquid
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 6 months.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A1221
Product name
AH6809
Purity
≥98%, crystalline solid or supercooled liquid
Packaging
5mg
Price
$66
Updated
2024/03/01
Cayman Chemical
Product number
14050
Product name
AH 6809
Purity
≥98%
Packaging
1mg
Price
$19
Updated
2024/03/01
Cayman Chemical
Product number
14050
Product name
AH 6809
Purity
≥98%
Packaging
5mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
14050
Product name
AH 6809
Purity
≥98%
Packaging
10mg
Price
$138
Updated
2024/03/01
Cayman Chemical
Product number
14050
Product name
AH 6809
Purity
≥98%
Packaging
50mg
Price
$595
Updated
2024/03/01
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6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production

Description

AH 6809 is an EP and DP receptor antagonist with nearly equal affinity for the cloned human EP1, EP2, EP3-III, and DP1 receptors. AH 6809 blocks the PGE2-induced accumulation of cAMP in COS cells transfected with the human EP2 receptor. It also blocks the accumulation of Ca2+ in Xenopus oocytes expressing the human EP1 receptor. In the human and guinea pig, the activity profile of AH 6809 is similar to that of SC-19220, but it is somewhat more potent. In the mouse, AH 6809 has the highest affinity for the EP2 receptor, but also acts as a weak ligand at the murine EP1 and DP1 receptors. In whole human platelets, AH 6809 is an effective antagonist of the antiaggregatory actions of PGD2, but not PGI2, with an EC50 of about 5 x 10−5 M.

Uses

AH-6809 is a prostaglandin E2 receptor antagonist.

Definition

ChEBI: 9-oxo-6-propan-2-yloxy-2-xanthenecarboxylic acid is a member of xanthones.

Biological Activity

Antagonist at prostaglandin EP 1 (pA 2 = 6.8 ) and EP 2 (K i = 350 nM) receptors. Also weakly inhibits DP receptors (pA 2 = 4.45).

storage

Store at RT

References

1) Coleman in Prostaglandins and Related Substances: A Practical Approach; ILR Press, Oxford and Washington D.C. 1987, pg 267

6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID Suppliers

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33458-93-4, 6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACIDRelated Search:

METYRAPONE Lovastatin URB597 NAGLY Titanium diisopropoxide bis(acetylacetonate) Aluminium isopropoxide Oxygen-fluorine acid Xanthone 4-(3-HYDROXYPHENOXY)BENZOIC ACID 6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID 3-acetyl-4-hydroxybenzoic acid 4-(3-METHOXY-PHENOXY)-BENZALDEHYDE

  • 6-ISOPROPOXY-9-OXOXANTHENE-2-CARBOXYLIC ACID
  • 6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID
  • AH 6809
  • 6-(1-Methylethoxy)-9-oxo-9H-xanthene-2-carboxylic acid
  • 6-Isopropoxy-9-oxo-9H-xanthene-2-carboxylic acid
  • AH6809;AH-6809
  • 9H-Xanthene-2-carboxylic acid, 6-(1-methylethoxy)-9-oxo-
  • Prostaglandin Receptor,AH-6809,inhibit,Inhibitor,AH6809,AH 6809
  • 9-oxo-6-(propan-2-yloxy)-9H-xanthene-2-carboxylic acid
  • 33458-93-4