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Tert-buthyl Pitavastatin

Product Name
Tert-buthyl Pitavastatin
CAS No.
586966-54-3
Chemical Name
Tert-buthyl Pitavastatin
Synonyms
Tert-butyl Pitavastatin;ert-Buthyl Pitavastatin;Tert-buthyl Pitavastatin;Pitavastatin t-Butyl Ester;Pitavastatin tert-Butyl Ester;pitavastatin-defluorination impurity;(3R,5S,E)-tert-butyl 7-(2-cyclopropyl-4-;5-dihydroxy-6-heptenoic acid tert-butyl ester;Pitavastatin Impurity 11(Pitavastatin t-Butyl Ester);6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3
CBNumber
CB62123321
Molecular Formula
C29H32FNO4
Formula Weight
477.57
MOL File
586966-54-3.mol
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Tert-buthyl Pitavastatin Property

Boiling point:
674.5±55.0 °C(Predicted)
Density 
1.235±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Sligthly), Methanol (Slightly)
form 
Solid
pka
13.52±0.20(Predicted)
color 
White to Off-White
InChIKey
RCARMBIYAHBUHR-UQECUQMJSA-N
SMILES
C(OC(C)(C)C)(=O)C[C@H](O)C[C@H](O)/C=C/C1=C(C2=CC=C(F)C=C2)C2C(N=C1C1CC1)=CC=CC=2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B695670
Product name
tert-ButylPitavastatin
Packaging
50mg
Price
$105
Updated
2021/12/16
TRC
Product number
B695670
Product name
tert-ButylPitavastatin
Packaging
100mg
Price
$165
Updated
2021/12/16
TRC
Product number
B695670
Product name
tert-ButylPitavastatin
Packaging
500mg
Price
$495
Updated
2021/12/16
AK Scientific
Product number
X6294
Product name
(3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoicacid,1,1-dimethylethylester
Packaging
1g
Price
$81
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0079133
Product name
PITAVASTATIN TERT-BUTYL ESTER
Purity
95.00%
Packaging
5G
Price
$909.56
Updated
2021/12/16
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Tert-buthyl Pitavastatin Chemical Properties,Usage,Production

Uses

tert-Butyl Pitavastatin is used to prepare hemicalcium salt.

Synthesis

147489-06-3

586966-54-3

Tert-butyl (4R,6S)-6-[[(1E)-2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl]-2,2-dimethyl-1,3-dioxane-4-acetate (1.5 kg) was used as raw material and dissolved in acetonitrile (16 L). A mixture of 35% HCl solution (0.91 kg) and purified water (9.5 kg) was slowly added under stirring conditions over a period of 2 hours. Stirring of the reaction mixture was continued for 1 hour. The progress of the reaction was monitored by HPLC and the reaction was terminated after confirming complete consumption of the raw material. The reaction mixture was neutralized with sodium bicarbonate and subsequently extracted with ethyl acetate. The organic layer was separated, washed with sodium chloride solution (1.5 kg) and concentrated under reduced pressure. The concentrated residue was dissolved in ethyl acetate (1.5 L) and hexane (9 L) was slowly added. The mixture was cooled to about 10 °C with continuous stirring for 2 hours. The precipitate was collected by filtration under reduced pressure and dried under reduced pressure at about 50 °C to afford the target product (3R,5S,E)-tert-butyl (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate (1.22 kg) as white crystals in 88.4% yield.HPLC purity: 98.555%.

References

[1] Patent: US2013/72688, 2013, A1. Location in patent: Paragraph 0060-0062
[2] Patent: US2012/16129, 2012, A1. Location in patent: Page/Page column 13-14
[3] Patent: WO2014/108795, 2014, A2. Location in patent: Page/Page column 19; 20
[4] Patent: JP6231262, 2017, B2. Location in patent: Paragraph 0030-0032

Tert-buthyl Pitavastatin Preparation Products And Raw materials

Raw materials

Preparation Products

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Tert-buthyl Pitavastatin Suppliers

China 127 India 5 United States 10 Global 142
Tlc Pharma Tech
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India
ProdList
90
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58
SynZeal Research Pvt Ltd
Tel
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Email
standards@synzeal.com
Country
India
ProdList
6514
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58
Pharmaffiliates Analytics and Synthetics P. Ltd
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Email
mktg@pharmaffiliates.com
Country
India
ProdList
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58
A.J Chemicals
Tel
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Email
sales@ajchem.in
Country
India
ProdList
6100
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58
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View Lastest Price from Tert-buthyl Pitavastatin manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
Tert-buthyl Pitavastatin 586966-54-3
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-10-09
Hangzhou ICH Biofarm Co., Ltd
Product
Tert-buthyl Pitavastatin 586966-54-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200
Release date
2023-07-12
Zhuozhou Wenxi import and Export Co., Ltd
Product
Tert-buthyl Pitavastatin 586966-54-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26

586966-54-3, Tert-buthyl PitavastatinRelated Search:

Pitavastatin lactone dehydration Pitavastatin Impurity 2 Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate Pitavastatin Methyl Ester PITAVASTATIN LACTONE 2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxaldehyde 2-Cyclopropyl-3-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)quinoline (E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-2-propenenitrile 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol Pitavastatin calcium [2-Cyclopropyl-4-(4-fluorophenyl)-quinolin-3-ylmethyl]-triphenyl-phosphonium bromido tert-Butyl (4R-cis)-6-formaldehydel-2,2-dimethyl-1,3-dioxane-4-acetate (E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal (3S,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid CalciuM Salt (3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid (3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid CalciuM Salt (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester 3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline

  • Tert-buthyl Pitavastatin
  • (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid tert-butyl ester
  • Pitavastatin tert-Butyl Ester
  • 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid tert-butyl ester
  • pitavastatin-defluorination impurity
  • (3R,5S,6E)7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydrosy-6-heptaneacid,ethylester
  • Tert-butyl Pitavastatin
  • Pitavastatin t-Butyl Ester
  • (3R,5S,E)-tert-Butyl 7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-eno
  • (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid t-butyl ester
  • Pitavastatin Impurity 11(Pitavastatin t-Butyl Ester)
  • 5-dihydroxy-6-heptenoic acid tert-butyl ester
  • 6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3
  • (3R,5S,E)-tert-butyl 7-(2-cyclopropyl-4-
  • tert-butyl (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate
  • 6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, 1,1-dimethylethyl ester, (3R,5S,6E)-
  • sodium (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)-1- oxidoquinolin-3-yl)-3,5-dihydroxyhept-6-enoate
  • ert-Buthyl Pitavastatin
  • (3R,5S,Z)-Tert-butyl 7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate (Pitavastatin Impurity)
  • Ethyl7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptanoate
  • 586966-54-3
  • C29H32FNO4
  • Other APIs