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Atracurium besylate

Product Name
Atracurium besylate
CAS No.
64228-79-1
Chemical Name
Atracurium besylate
Synonyms
Atracurium;ATRACURIUM BESYLATE;AtracuriuM Besylate USP/EP/BP;Atracurium Impurity 2(Trans - single -;Atracurium for peak identification CRS;5-[3-[1-[(3,4-DiMethoxyphenyl)Methyl]-6,7-diMethoxy-2-Methyl-3,4-dihydro-1H-isoquinolin-2-yl]propano;2,2'-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium];2,2'-[Pentane-1,5-diylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolin-2-ium];5-[3-[1-[(3,4-Dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-yl]propanoyloxy]pentyl 3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-yl]propanoate
CBNumber
CB62130242
Molecular Formula
C53H72N2O12+2
Formula Weight
929.16
MOL File
64228-79-1.mol
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Atracurium besylate Property

Melting point:
185-194 ºC
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
InChI
InChI=1S/C53H72N2O12/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-37-15-17-45(59-4)47(31-37)61-6/h14-17,30-35,42-43H,11-13,18-29H2,1-10H3/q+2
InChIKey
YXSLJKQTIDHPOT-UHFFFAOYSA-N
SMILES
C(C1C=CC(OC)=C(OC)C=1)C1[N+](CCC2=CC(OC)=C(OC)C=C12)(C)CCC(=O)OCCCCCOC(=O)CC[N+]1(CCC2=CC(OC)=C(OC)C=C2C1CC1C=CC(OC)=C(OC)C=1)C
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd
Product number
orb134593
Product name
Atracurium besylate
Purity
>99%
Packaging
100mg
Price
$510
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009205
Product name
ATRACURIUM
Purity
95.00%
Packaging
25MG
Price
$705.6
Updated
2021/12/16
Biorbyt Ltd
Product number
orb134593
Product name
Atracurium besylate
Purity
>99%
Packaging
250mg
Price
$765
Updated
2021/12/16
Biorbyt Ltd
Product number
orb134593
Product name
Atracurium besylate
Purity
>99%
Packaging
1g
Price
$1504.5
Updated
2021/12/16
AvaChem
Product number
2251B
Product name
Atracurium
Packaging
25mg
Price
$39
Updated
2021/12/16
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Atracurium besylate Chemical Properties,Usage,Production

Chemical Properties

Atracurium besylate is a white to yellow-white powder with slight hygroscopicity. It is soluble in water and very soluble in ethanol, acetonitrile and dichloromethane. It contains three isomers: cis-cis, cis-trans and trans-trans.

Uses

Atracurium besylate is a neuromuscular-blocking drug or skeletal muscle relaxant in the category ofnon-depolarizing neuromuscular-blocking drugs, used adjunctively in anesthesiato facilitate endotracheal intubation and to provide skeletal muscle relaxationduring surgery or mechanical ventilation.The drug atracurium besylate can be used most advantageously if muscle twitch response to peripheral nerve stimulation is monitored.

Definition

ChEBI: Atracurium besylate is the bisbenzenesulfonate salt of atracurium. It has a role as a nicotinic antagonist and a muscle relaxant. It is a quaternary ammonium salt and an organosulfonate salt. It contains an atracurium.

Hazard

Extremely toxic.

Pharmacokinetics

Atracurium besylate, a new non-depolarizing neuromuscular blocking agent, with short to intermediary duration of action and no significant cardiovascular effects. Not dependent on kidney function for elimination, it provides clinical advantages over other non-depolarizing, neuromuscular blocking agents. In vitro, in human plasma, the half-life of the drug was similar to that in buffer at the same pH being approximately 25 min (Hughes and Chappie, 1980).

Synthesis

Atracurium is 2,2-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]] bis [1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium] dibenzene sulfonate (15.1.12). This compound is synthesized from bis-acrylic ester of 1,5-pentandiol (15.1.10), which is synthesized from acrylic acid chloride and 1, 5-pentandiol. Two molecules of a secondary amine, tetrahydropapaverine, are joined to the product in a Michael reaction, forming compound (15.1.11). Then both nitrogen atoms are methylated by methylbenzenesulfonate, giving atracurium (15.1.12).

Metabolism

Atracurium besylate is a nondepolarizing neuromuscular blocker in which the quaternary ammonium groups are located in two substituted tetrahydroisoquinoline rings separated by an aliphatic diester. It has a duration of action slightly longer than that of succinylcholine. Atracurium is not metabolized in the liver; rather, it undergoes hydrolysis of the ester functional groups that connect the two quaternary nitrogens. It also undergoes Hofmann elimination, a nonenzymatic, base-catalyzed decomposition, to yield laudanosine, which is inactive. T hus, termination of the effects of atracurium are independent of renal elimination. Because of this unusual metabolic profile, it is useful in patients with hepatic or renal disease.

Atracurium besylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Atracurium besylate Suppliers

TEVA PHARMACEUTICAL INDUSTRIES LTD
Tel
--
Fax
--
Email
megan.carroll@tevapharm.com
Country
Israel
ProdList
296
Advantage
58
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View Lastest Price from Atracurium besylate manufacturers

Hebei Mingeng Biotechnology Co., Ltd
Product
Atracurium 64228-79-1
Price
US $200.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg/Month
Release date
2022-11-24
Shijiazhuang Gantuo Biotechnology Co., Ltd
Product
atracurium 64228-79-1
Price
US $100.00/mg
Min. Order
25mg
Purity
99%
Supply Ability
1000g
Release date
2023-03-10
Dideu Industries Group Limited
Product
AtracuriuM Besylate 64228-79-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-07

64228-79-1, Atracurium besylateRelated Search:


  • Atracurium
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  • 2,2'-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium]
  • 2,2'-[Pentane-1,5-diylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolin-2-ium]
  • 5-[3-[1-[(3,4-DiMethoxyphenyl)Methyl]-6,7-diMethoxy-2-Methyl-3,4-dihydro-1H-isoquinolin-2-yl]propano
  • ATRACURIUM BESYLATE
  • Atracurium for peak identification CRS
  • AtracuriuM Besylate USP/EP/BP
  • Atracurium Impurity 2(Trans - single -
  • 64228-79-1