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Salmeterol xinafoate

Product Name
Salmeterol xinafoate
CAS No.
94749-08-3
Chemical Name
Salmeterol xinafoate
Synonyms
1-Hydroxy-2-naphthoate;Serevent;Salmeterol hydroxynaphthoate;Salmeterol Xinafoate (1609603);Arial;SN 408;Siduomi;GR 3343G;GR-33343G;Salmetedur
CBNumber
CB2751968
Molecular Formula
C36H45NO7
Formula Weight
603.74
MOL File
94749-08-3.mol
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Salmeterol xinafoate Property

Melting point:
137-138°C
storage temp. 
2-8°C
solubility 
H2O: slightly soluble
form 
solid
color 
white
Merck 
14,8337
InChIKey
XTZNCVSCVHTPAI-UHFFFAOYSA-N
SMILES
C12C=CC=CC=1C(O)=C(C(=O)O)C=C2.C1(C(O)CNCCCCCCOCCCCC2C=CC=CC=2)=CC=C(O)C(CO)=C1
CAS DataBase Reference
94749-08-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
3
RTECS 
QJ1970500
HS Code 
2922504500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0000423
Product name
Salmeterol xinafoate for system suitability
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
6.105 mg
Price
$156
Updated
2025/07/31
Sigma-Aldrich
Product number
Y0000422
Product name
Salmeterol xinafoate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
70 mg
Price
$156
Updated
2025/07/31
Sigma-Aldrich
Product number
S5068
Product name
Salmeterol xinafoate
Purity
≥98% (HPLC), solid
Packaging
10mg
Price
$230.85
Updated
2025/07/31
Sigma-Aldrich
Product number
BP1181
Product name
Salmeterol xinafoate
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100 mg
Price
$287
Updated
2025/07/31
Sigma-Aldrich
Product number
1609603
Product name
Salmeterol xinafoate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
150mg
Price
$1060
Updated
2025/07/31
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Salmeterol xinafoate Chemical Properties,Usage,Production

Description

Salmeterol hydroxynaphthoate is a new long-acting β2-selective adrenoceptor agonist introduced as a bronchodilator for the treatment of reversible airway obstruction in asthma and chronic bronchitis. It has bronchodilatory activity as intense and four times longerlasting than equivalent doses of salbutamol. Salmeterol hydroxynaphthoate is reported to be the first bronchodilator with significant anti-inflammatory activity and hence could complement prophylactic corticosteroid therapy.

Description

Salmeterol is a long-acting β2-adrenergic receptor agonist (β2-AR; EC50s = 0.79, 63.1, and 9.4 nM for β2-, β1-, and β3-ARs, respectively). It inhibits electrically-stimulated contraction of isolated guinea pig trachea strips (EC50 = 2.51 nM) and histamine-induced bronchoconstriction in guinea pigs via aerosol administration of doses ranging from 0.12 to 12 mM. Salmeterol binds to an exosite domain of β2-adrenergic receptors, producing a slow onset of action and prolonged activation. Formulations containing salmeterol have been used in the treatment of asthma, including exercise-induced asthma, and chronic obstructive pulmonary disease.

Chemical Properties

White to Off-White Solid

Originator

Glaxo (United Kingdom)

Uses

A ?-Adrenergic agonist. Structural analog of albuterol

Uses

A β2-Adrenergic agonist. Structural analog of Albuterol (A514500).

Uses

Smooth wheezing anti-inflammatory

Uses

Bronchodilator; Beta2-adrenoceptor agonist

Application

Salmeterol xinafoate is a potent and selective β2-adrenoceptor agonist (EC50 = 5.3 nM) that displays bronchodilator actions. Unlike other β2- adrenoceptor agonists, Salmeterol binds to exo-site domain of β2-AR receptors, producing a slow onset of action and prolonged activation. Clinically used for the treatment of asthma and chronic obstructive pulmonary disease(COPD).

Definition

ChEBI: Salmeterol xinafoate is a naphthoic acid.

brand name

Serevent (GlaxoSmithKline).

Biochem/physiol Actions

β2-adrenoceptor agonist.

storage

Desiccate at RT

References

[1] PANAYIOTIS A. PROCOPIOU . The discovery of long-acting saligenin β2 adrenergic receptor agonists incorporating a urea group[J]. Bioorganic & Medicinal Chemistry, 2011, 19 20: Pages 6026-6032. DOI: 10.1016/j.bmc.2011.08.043
[2] D.I. BALL. Salmeterol, a novel, long-acting β2-adrenoceptor agonist: characterization of pharmacological activity in vitro and in vivo[J]. British Journal of Pharmacology, 1991, 104 3: 665-671. DOI: 10.1111/j.1476-5381.1991.tb12486.x
[3] BASAK ISIN. Identifying ligand binding conformations of the β2-adrenergic receptor by using its agonists as computational probes.[J]. ACS Applied Bio Materials, 2012: e50186. DOI: 10.1371/journal.pone.0050186

Salmeterol xinafoate Preparation Products And Raw materials

Raw materials

Preparation Products

Atracurium besylate
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Salmeterol xinafoate Suppliers

Americas 1 Canada 3 China 285 Europe 3 Finland 2 France 3 Germany 5 Greece 1 India 79 Italy 2 Japan 1 Mexico 1 Nepal 1 Poland 1 South Korea 1 Spain 2 Switzerland 4 United Arab Emirates 1 United Kingdom 19 United States 34 Global 449
Bono Kangyuan (Beijing) Pharmaceutical Technology Co., Ltd
Tel
010-56380788-8515 16619769925
Email
wch013@bionna.cn
Country
China
ProdList
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Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
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55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
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Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
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JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
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Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
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LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
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Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
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Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
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View Lastest Price from Salmeterol xinafoate manufacturers

Sinoway Industrial co., ltd.
Product
Salmeterol Xinafoate 94749-08-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20TONS
Release date
2025-04-27
Zibo Hangyu Biotechnology Development Co., Ltd
Product
Salmeterol xinafoate 94749-08-3
Price
US $55.00-550.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-20
Zhuozhou Wenxi import and Export Co., Ltd
Product
Salmeterol xinafoate 94749-08-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

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