Narasin
- Product Name
- Narasin
- CAS No.
- 58331-17-2
- Chemical Name
- Narasin
- Synonyms
- NARASIN;HainanMycin;henanamycin;Hainan drug;Narasin sodiuM;naransin sodium;Naracin sodium salt;Narasin (sodium salt);4-MethylsalinoMycin sodiuM;Salinomycin, 4-methyl-, monosodium salt, (4S)-
- CBNumber
- CB62130994
- Molecular Formula
- C43H71O11Na
- Formula Weight
- 789.04
- MOL File
- 58331-17-2.mol
Narasin Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 19447
- Product name
- Narasin (sodium salt)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $124
- Updated
- 2024/03/01
- Product number
- 19447
- Product name
- Narasin (sodium salt)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $556
- Updated
- 2024/03/01
- Product number
- N378773
- Product name
- NarasinSodium
- Packaging
- 5mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 018018
- Product name
- Narasin
- Packaging
- 1mg
- Price
- $375
- Updated
- 2021/12/16
- Product number
- N378773
- Product name
- NarasinSodium
- Packaging
- 1mg
- Price
- $120
- Updated
- 2021/12/16
Narasin Chemical Properties,Usage,Production
Uses
Narasin sodium is prepared from narasin taking advantage of the carboxylic acid which ionises and readily forms the salt in sodium hydroxide solutions. Narasin shows broad spectrum activity against Gram positive bacteria including anaerobes and mycoplasma, and also possesses antiviral and limited antifungal activity. Narasin is used in the animal health industry as an in-feed antibiotic and growth promotant.
Uses
Narasin sodium is an antibacterial and limited antifungal agent.
brand name
Monteban (Lilly).
Biological Activity
narasin, isolated from certain streptomyces sp. is an ionophore antibiotic. as a coccidiostat, it can be used in veterinary practice for gastrointestinal parasites. narasin has been shown to induce tumor necrosis factor-related apoptosis-induced ligand (trail)-mediated apoptosis by er stress in glioma cells and to dampen nf-κb signaling by suppressing the phosphorylation of iκbα. nf-κb, as a transcription factor, plays a vital role across many cellular processes which are involved in neuronal and embryonic development, cell proliferation, apoptosis, and immune responses to infection and inflammation.
in vitro
narasin caused suicidal erythrocyte death or eryptosis. when human erythrocytes were exposed to narasin, it was shown that narasin resulted in the increase of annexin-v-binding indicating cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface and the decrease of forward scatter reflecting cell shrinkage, which indicated the death of erythrocyte [1]. narasin blocked nf-κb signaling via inhibition of iκbα phosphorylation at a lower concentration [2].
in vivo
new zealand white rabbits were given narasin 4-48 p. p. m, in pelleted feed. after 4 weeks, the experiments indicated that narasin protected rabbits from severe coccidiosis induced by e. flavescens, e. perforans e. magna, e. intestinalis, and e. stiedai. in addition, narasin reduced oocyst output in a highly effective fashion [3].
IC 50
3.2 μm: blocks nf-κb signaling via inhibition of iκbα phosphorylation
References
[1]. bouguerra, g., bissinger, r., abbes, s., & lang, f. stimulation of eryptosis by narasin. cellular physiology and biochemistry. 2015; 37(5):1807-1816.
[2]. miller, s., huang, r., sakamuru, s., shukla, s., attene-ramos, m., & shinn, p. et al. identification of known drugs that act as inhibitors of nf-κb signaling and their mechanism of action. biochemical pharmacology. 2010; 79(9): 1272-1280.
[3]. peeters, j., geeroms, r., antoine, o., mammerickx, m., & halen, p. efficacy of narasin against hepatic and intestinal coccidiosis in rabbits. parasitology. 1981; 83(02): 293-301.
Narasin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Narasin manufacturers
- Product
- Narasin 58331-17-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2021-07-30
- Product
- Narasin 58331-17-2
- Price
- US $3.00-1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-16
- Product
- Narasin 58331-17-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-08-29