5-CHLORO-2-METHOXYBENZALDEHYDE
- Product Name
- 5-CHLORO-2-METHOXYBENZALDEHYDE
- CAS No.
- 7035-09-8
- Chemical Name
- 5-CHLORO-2-METHOXYBENZALDEHYDE
- Synonyms
- AKOS B014153;ASISCHEM R42152;ART-CHEM-BB B014153;CHEMBRDG-BB 3014153;5-Chloro-2-Anisaldehyde;5-CHLORO-2-METHOXYBENZALDEHYDE;Benzaldehyde, 5-chloro-2-methoxy-;2-Bromo-5-(trifluoromethyl)acetophenone;JR-13439, 5-Chloro-2-methoxybenzaldehyde, 97%;5-chloro-2-methoxybenzaldehyde(SALTDATA: FREE)
- CBNumber
- CB6214511
- Molecular Formula
- C8H7ClO2
- Formula Weight
- 170.59
- MOL File
- 7035-09-8.mol
5-CHLORO-2-METHOXYBENZALDEHYDE Property
- Melting point:
- 75-79℃
- Boiling point:
- 152 °C(Press: 15 Torr)
- Density
- 1.244±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- Appearance
- White to light yellow Solid
- Sensitive
- Air Sensitive
- InChI
- InChI=1S/C8H7ClO2/c1-11-8-3-2-7(9)4-6(8)5-10/h2-5H,1H3
- InChIKey
- HXTWDGGMXZXOIV-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC(Cl)=CC=C1OC
- CAS DataBase Reference
- 7035-09-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CDS005116
- Product name
- 5-Chloro-2-methoxybenzaldehyde
- Purity
- AldrichCPR
- Packaging
- 100mg
- Price
- $70.9
- Updated
- 2024/03/01
- Product number
- C596573
- Product name
- 5-Chloro-2-methoxybenzaldehyde
- Packaging
- 2.5g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- OR53121
- Product name
- 5-Chloro-2-methoxybenzaldehyde
- Packaging
- 25g
- Price
- $269
- Updated
- 2021/12/16
- Product number
- OR53121
- Product name
- 5-Chloro-2-methoxybenzaldehyde
- Packaging
- 5g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 015723
- Product name
- 5-Chloro-2-methoxybenzaldehyde
- Purity
- 95%
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
5-CHLORO-2-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production
Synthesis Reference(s)
Synthetic Communications, 19, p. 799, 1989 DOI: 10.1080/00397918908050996
Synthesis
635-93-8
74-88-4
7035-09-8
Step 1: Preparation of 5-chloro-2-methoxybenzaldehyde 5-Chloro-2-hydroxybenzaldehyde (20 g, 128 mmol) was dissolved in N,N-dimethylformamide (DMF, 70 mL) and the solution was cooled to 5-10 °C. Sodium hydride (7.69 g, 192 mmol) was added to the solution in small portions over 20 min. Subsequently, iodomethane (23.8 mL, 384 mmol) was added dropwise while keeping the temperature of the reaction mixture below 15 °C. After addition, the reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the mixture was poured into pre-cooled saturated ammonium chloride solution (250 mL) and a white precipitate precipitated. The precipitate was collected by filtration and dried under vacuum. The resulting solid was ground with a solvent mixture of pentane and ether (4:1, 100 mL) to afford 18 g (82.58% yield) of the target product, 5-chloro-2-methoxybenzaldehyde, as a white solid.LC-MS analysis showed m/z = 170.1 ([M+H]+).
References
[1] Chemical Communications, 2011, vol. 47, # 9, p. 2679 - 2681
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 12, p. 5019 - 5032
[3] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 12, p. 2768 - 2776
[4] Patent: WO2014/151472, 2014, A1. Location in patent: Paragraph 00392-00393
[5] Patent: WO2016/40315, 2016, A1. Location in patent: Paragraph 00435; 00436
5-CHLORO-2-METHOXYBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-CHLORO-2-METHOXYBENZALDEHYDE manufacturers
- Product
- 5-Chloro-2-methoxybenzaldehyde 7035-09-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2 MTs
- Release date
- 2024-08-06
- Product
- 5-CHLORO-2-METHOXYBENZALDEHYDE 7035-09-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-22