P-HYDROXYMETHAMPHETAMINE Property

Melting point:

162-163°

Boiling point:

293.09°C (rough estimate)

Density 

1.0203 (rough estimate)

refractive index 

1.4820 (estimate)

storage temp. 

−20°C

solubility 

Methanol (Slightly)

pka

9.82±0.15(Predicted)

Safety

Hazard Codes 

Xi,T,F

Risk Statements 

36/37/38-39/23/24/25-23/24/25-11

Safety Statements 

26-36-45-36/37-16-7

WGK Germany 

3

RTECS 

SL8400000

Toxicity

LD50 parenteral in mouse: 100mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P-HYDROXYMETHAMPHETAMINE Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Originator

Pholedrine Sulfate, ZYF Pharm Chemical

Uses

An a-adrenergic agonist. Antihypotensive.

Definition

ChEBI: Pholedrine is a member of amphetamines.

Manufacturing Process

100 g β-(methoxyphenyl)isopropylamine prepared, for example by reduction of p-methoxybenzylmethylketone with hydrogen and nickel catalyst in presence of ammonia or by Mannix's method, 250 ml ethanol and calculated quantity of solution of formaldehyde and 70 g activated aluminum shaving were heated for 6 hours by stirring. The mixture was filtered, the solvent was removed in vacuum and the residue was dissolved in ethanol contained hydrochloric acid. The prepared hydrochloride of β-(pmethoxyphenyl)isopropylmethylamine had MP: 174°C.
In practice it is usually used as sulfate.

Therapeutic Function

Sympathomimetic, Mydriatic, Analeptic, Vasopressor