n-Docosanol
- Product Name
- n-Docosanol
- CAS No.
- 661-19-8
- Chemical Name
- n-Docosanol
- Synonyms
- BEHENYL ALCOHOL;DOCOSANOL;Behenic alcohol;1-DOCOSANOL;Docosan-1-ol;BEHENYLIC ALCOHOL;ik2;lidavol;tadenan;JARCOL 22
- CBNumber
- CB6219657
- Molecular Formula
- C22H46O
- Formula Weight
- 326.6
- MOL File
- 661-19-8.mol
n-Docosanol Property
- Melting point:
- 65-72 °C(lit.)
- Boiling point:
- 180 °C0.22 mm Hg(lit.)
- Density
- d75 0.8063 g/ml; d85 0.7986 g/ml; d95 0.7911 g/ml
- vapor pressure
- 0Pa at 25℃
- refractive index
- n75 1.4360
- storage temp.
- Store below +30°C.
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- pka
- 15.20±0.10(Predicted)
- form
- Pellets or Tablets
- color
- White
- Water Solubility
- Insoluble
- Merck
- 13,3433
- BRN
- 1770470
- Stability:
- Stable. Combustible. Incompatible with strong oxidizing agents.
- LogP
- 8.3 at 20℃
- CAS DataBase Reference
- 661-19-8(CAS DataBase Reference)
- NIST Chemistry Reference
- 1-Docosanol(661-19-8)
- EPA Substance Registry System
- 1-Docosanol (661-19-8)
Safety
- Safety Statements
- 24/25
- WGK Germany
- -
- RTECS
- JR1315000
- TSCA
- Yes
- HS Code
- 29051900
- Hazardous Substances Data
- 661-19-8(Hazardous Substances Data)
- Toxicity
- LD50 intraperitoneal in mouse: > 800mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PHR2264
- Product name
- Docosanol(n-Docosanol)
- Purity
- PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial
- Packaging
- 1G
- Price
- $180
- Updated
- 2024/03/01
- Product number
- 8.22047
- Product name
- 1-Docosanol
- Purity
- for synthesis
- Packaging
- 100g
- Price
- $72.4
- Updated
- 2024/03/01
- Product number
- 169102
- Product name
- 1-Docosanol
- Purity
- 98%
- Packaging
- 50g
- Price
- $78.9
- Updated
- 2024/03/01
- Product number
- D0964
- Product name
- 1-Docosanol
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $52
- Updated
- 2024/03/01
- Product number
- D0964
- Product name
- 1-Docosanol
- Purity
- >98.0%(GC)
- Packaging
- 500g
- Price
- $267
- Updated
- 2024/03/01
n-Docosanol Chemical Properties,Usage,Production
Chemical Properties
1-DOCOSANOL is white powder
Uses
1-Docosanol works as a surfactant in cosmetics. 1-Docosanol cream has also been approved by the US Food and Drug Administration as a safe and effective topical treatment for herpes labialis
Uses
antiviral
Uses
n-Docosanol is a binder and an emulsion stabilizer. It is also used to increase a formulation’s viscosity. This is a mixture of fatty alcohols. behenyl alcohol may be used for any number of purposes in a cosmetic formulation, including as an emollient, a binder, an emulsion stabilizer, or to increase a product’s viscosity. It may be derived either synthetically or from plants.
Indications
Docosanol (Abreva) is a long-chain saturated alcohol
that is clinically effective against HSV. It has in vitro activity
against many enveloped viruses, including CMV,
influenzavirus, and respiratory syncytial virus.
Docosanol is not directly virucidal; instead, it blocks
the entry of the virion into the host cell by inhibiting the
fusion of the viral envelope with the host plasma membrane.
Because it does not affect viral replication or protein
production, it may be less susceptible to the development
of resistance than other antiviral drugs.
Definition
1-DOCOSANOL is a long-chain, saturated fatty alcohol.
General Description
1-Docosanol inhibits replication of certain viruses (herpes simplex virus and respiratory syncytial virus) within primary target cells in vitro. It has been isolated from Clematis brevicaudata.
Flammability and Explosibility
Not classified
Pharmaceutical Applications
1-DOCOSANOL is a 22-carbon straight chain alcohol licensed for over-thecounter sales for the topical treatment of herpes labialis. It is thought to act by blocking viral fusion with the host cell, although definitive studies are lacking. The clinical relevance of the antiviral activity has been debated and the place of this medication as a treatment of herpes labialis remains to be established.
Clinical Use
Docosanol cream is approved for the over-the-counter treatment of herpes labialis. It shortens the duration of symptoms of cold sores and fever blisters but does not provide symptomatic relief.
Side effects
Adverse effects of docosanol are minimal. Skin irritation occurs infrequently. Drug interactions are not anticipated.
Purification Methods
Crystallise docosanol from ether or chloroform/ether. [Beilstein 1 IV 1906.]
n-Docosanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from n-Docosanol manufacturers
- Product
- 1-Docosanol 661-19-8
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- More than 99%
- Supply Ability
- 2000KG/Month
- Release date
- 2024-05-11
- Product
- 1-Docosanol 661-19-8
- Price
- US $99.00-35.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-10
- Product
- Behenyl Alcohol 661-19-8
- Price
- US $100.00-95.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Ex.20t
- Release date
- 2023-11-09