(S)-1-Boc-3-(aminomethyl)pyrrolidine

Product Name: (S)-1-Boc-3-(aminomethyl)pyrrolidine
CAS No.: 199175-10-5
Chemical Name: (S)-1-Boc-3-(aminomethyl)pyrrolidine
Synonyms: (S)-1-Boc-3-(aminomethyl)...;S-1-N-Boc-3-aMinoMethypyrrolidine;(S)-1-BOC-3-AMINOMETHYLPYRROLIDINE;(S)-N-BOC-3-(AMINOMETHYL)PYRROLIDINE;(3S)-3-Aminomethyl-1-Boc-pyrrolidine;(S)-3-(Aminomethyl)-1-Boc-pyrrolidine;(S)-1-N-BOC-3-(AMINOMETHYL)PYRROLIDINE;(S)-3-(AMINOMETHYL)-1-N-BOC-PYRROLIDINE;(S)-1-Boc-3-(aminomethyl)pyrrolidine HCl;(S)-3-(Aminomethyl)-1-N-Boc-pyrrolidine ,98%
CBNumber: CB6220253
Molecular Formula: C10H20N2O2
Formula Weight: 200.28
MOL File: 199175-10-5.mol

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(S)-1-Boc-3-(aminomethyl)pyrrolidine Property

Boiling point:: 280.3±13.0 °C(Predicted)
Density: 1.044±0.06 g/cm3(Predicted)
refractive index: 1.4780
storage temp.: 2-8°C
pka: 10.12±0.29(Predicted)
form: Liquid
color: Colorless to yellow
optical activity: Consistent with structure
Sensitive: Air Sensitive
CAS DataBase Reference: 199175-10-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26
WGK Germany: 3
TSCA: No
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 689823
Product name: (S)-3-(Aminomethyl)-1-Boc-pyrrolidine
Purity: 95%
Packaging: 100mg
Price: $61
Updated: 2023/06/20

Sigma-Aldrich

Product number: 689823
Product name: (S)-3-(Aminomethyl)-1-Boc-pyrrolidine
Purity: 95%
Packaging: 500mg
Price: $252
Updated: 2023/06/20

TRC

Product number: B619663
Product name: (S)-1-Boc-3-(Aminomethyl)pyrrolidine
Packaging: 250mg
Price: $70
Updated: 2021/12/16

ChemSupplyAustralia

Product number: 300346
Product name: (S)-tert-Butyl 3-(aminomethyl)pyrrolidine-1-carboxylate, 96%
Packaging: 250mg
Price: $71.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB33402
Product name: (S)-1-N-Boc-3-(aminomethyl)pyrrolidine
Packaging: 250mg
Price: $80
Updated: 2021/12/16

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(S)-1-Boc-3-(aminomethyl)pyrrolidine Chemical Properties,Usage,Production

Uses

(S)-1-Boc-3-(Aminomethyl)pyrrolidine is a useful research chemical for organic synthesis and other chemical processes.It is used in preparation of isoquinoline derivatives as progranulin modulators useful in treatment of progranulin- associated disorders.

Synthesis

132945-76-7

199175-10-5

c) Synthesis of 1,1-dimethylethyl (3S)-3-(aminomethyl)-1-pyrrolidine carboxylate 1,1-Dimethylethyl (3R)-3-cyano-1-pyrrolidine carboxylate (73.9 mmol) was dissolved in ethanol (100 mL) in a Parr bottle. Raney Nickel (73.9 mmol; about 2 scoops of aqueous Raney Nickel) was added under nitrogen protection. After sufficiently displacing the air in the reaction system with nitrogen, the reaction mixture was placed on a Parr shaker at 60 psi hydrogen pressure overnight. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth under nitrogen protection and the filter cake was washed with a small amount of ethanol. Subsequently, the filter cake was immediately treated with water. The ethanol filtrate was concentrated under reduced pressure to give the title product as a clear oil (71.9 mmol, 97% yield). The enantiomeric ratio of the product was determined to be 95:5 (i.e. >90% ee). The product was analyzed by chiral HPLC (Daicel Chiralpak AD-H column, 4.6 x 150 mm; mobile phase: heptane:ethanol:isopropylamine=85:10:0.1; flow rate: 1.0 mL/min; UV detection wavelength: 215 nm), and the retention of 1,1-dimethylethyl (3R)-3-(aminomethyl)-1-pyrrolidinecarboxylate time was 4.4 min, and the retention time of 1,1-dimethylethyl (3S)-3-(aminomethyl)-1-pyrrolidine carboxylate was 4.8 min. 1H NMR (400 MHz, CDCl3) δ ppm: 1.47 (s, 9H), 1.54-1.73 (m, 1H), 1.91-2.13 (m, 1H), 2.28-2.52 (m, 1H), 2.78-2.93 (m, 1H), 2.95-3.16 (m, 1H), 3.24-3.67 (m, 5H) .

References

[1] Patent: WO2011/56635, 2011, A1. Location in patent: Page/Page column 50
[2] Patent: WO2011/66211, 2011, A1. Location in patent: Page/Page column 35-36
[3] Patent: WO2013/28445, 2013, A1. Location in patent: Page/Page column 51; 52
[4] Patent: WO2012/37298, 2012, A1. Location in patent: Page/Page column 83

(S)-1-Boc-3-(aminomethyl)pyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-1-Boc-3-(aminomethyl)pyrrolidine Suppliers

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View Lastest Price from (S)-1-Boc-3-(aminomethyl)pyrrolidine manufacturers

Career Henan Chemical Co

Product: (S)-1-Boc-3-(aminomethyl)pyrrolidine 199175-10-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 200KG
Release date: 2018-08-19

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